Nat Biomed Eng October 2021 PMID 34155355

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans.

Joshua C Doloff, Omid Veiseh, Roberto de Mezerville, Marcos Sforza, Tracy Ann Perry, Jennifer Haupt, Morgan Jamiel, Courtney Chambers, Amanda Nash, Samira Aghlara-Fotovat, Jessica L Stelzel, Stuart J Bauer, Sarah Y Neshat, John Hancock, Natalia Araujo Romero

Mentions

105
Peak: 18 in Jun 2021
across 5 sources since Jun 2021

Extended reach

215,896
potential audience

Total likes

130

Video views

6,038

Mentions per month

Jun 2021 – May 2025

Where it's discussed

  • News66 articles
  • X / Twitter27 posts
  • YouTube5 videos
  • Blogs4 articles
  • Facebook3 posts

AI synopsis

What people are saying

The overall tone reflects strong interest and engagement, with comments highlighting the importance of surface topography in immune response and safety, such as references to the potential for safer breast implant designs. Words like 'amazing' and mentions of the study's widespread publication convey excitement, while detailed considerations of how surface roughness can minimize complications demonstrate active engagement and recognition of its potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some explicitly praising its findings on surface topography reducing immune response.

InterestHigh interest

Discussions show high interest, referencing the research in contexts like improving implant safety and emphasizing the importance of surface design.

EngagementHigh engagement

Participants engage actively by sharing examples, linking the findings to implications for clinical applications and scientific advancement.

ImpactModerate impact

The discussions suggest the study could influence future medical practices and implant design, though some see it as an early step rather than a definitive breakthrough.

Abstract in brief

  • The study investigates how the surface roughness of silicone breast implants influences immune responses and fibrosis, using models in mice, rabbits, and humans, and finds that a roughness of 4 micrometers minimizes inflammation and foreign body response.
  • Implants with different surface textures can either suppress or provoke immune reactions; notably, roughness of 4 micrometers can reduce immune activity and fibrotic tissue formation, especially involving immunosuppressive T cells.
  • The research indicates that surface topography plays a key role in mediating the body's immune response, which could inform the design of safer breast implants with fewer complications.

Top posts

Most liked on X and Bluesky
Nature Biomedical Engineering
@natBME · X

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/GGSlUgGnob https://t.co/Ym8u4xIN0d

Jun 21, 2021 · 49 likes · 16 shares · 52,401 followers View post →
Nature Biomedical Engineering
@natBME · X

#19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/rtJaLPgm8Y https://t.co/ZaDrmOHl8D

Dec 31, 2021 · 15 likes · 4 shares · 52,401 followers View post →
João Conde
@CNanolab · X

Amazing study published ⁦@natBME⁩ by ⁦@DoloffLab⁩ and Langer Lab and co-workers ⁦@MIT⁩. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans | Nature Biomedical Engineering https://t.co/GU8SNMeNrk

Jun 22, 2021 · 8 likes · 1 share · 2,548 followers View post →
Türker Toktay
@delicorek · X

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits, and humans https://t.co/dNwxDU86jR #flowcytometry #surgicaloperations #implants https://t.co/ICMalMgPuT

Sep 15, 2022 · 1 like · 1 share · 39 followers View post →
Nature Biomedical Engineering
@natBME · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Oct 31, 2021 · 16 shares · 52,401 followers View post →
Palmarine128
@Palmarine128 · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 15,037 followers View post →

All mentions

Türker Toktay
@delicorek · X

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits, and humans https://t.co/dNwxDU86jR #flowcytometry #surgicaloperations #implants https://t.co/ICMalMgPuT

Sep 15, 2022 · 1 like · 1 share · 39 followers View post →
Kiana Sadi
@kianasaadi · X

RT @natBME: #19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https:/…

Jan 1, 2022 · 4 shares · 98 followers View post →
Arash Iraji
@ArashIraji · X

RT @natBME: #19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https:/…

Dec 31, 2021 · 4 shares · 117 followers View post →
Omid Veiseh
@veiseho · X

RT @natBME: #19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https:/…

Dec 31, 2021 · 4 shares · 3,487 followers View post →
Greg Timblin
@gtimblin · X

RT @natBME: #19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https:/…

Dec 31, 2021 · 4 shares · 814 followers View post →
Nature Biomedical Engineering
@natBME · X

#19: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/rtJaLPgm8Y https://t.co/ZaDrmOHl8D

Dec 31, 2021 · 15 likes · 4 shares · 52,401 followers View post →
Nature Biomedical Engineering
@natBME · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Oct 31, 2021 · 16 shares · 52,401 followers View post →
LibKey
@libkey_io · X

@dawso007 Get access rather than a paywall: https://t.co/DqnyuOZXfN Add https://t.co/SXSePSX5De to the DOI URL when sharing articles to promote scholarly communication

Jul 1, 2021 · 556 followers View post →
George Dawson
@dawso007 · X

Interesting consideration for foreign body reactions. Doloff, J.C., Veiseh, O., de Mezerville, R. et al. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans. Nat Biomed Eng (2021). https://t.co/L0lbJP0W6m

Jul 1, 2021 · 7,818 followers View post →
Kevin Dzobo
@DrKevinDzobo · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 26, 2021 · 16 shares · 383 followers View post →
Kevin Dzobo
@DrKevinDzobo · X

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/b7Zy2FtS0Z

Jun 26, 2021 · 383 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/BrHExmKxdU #breastcancer #oncology https://t.co/gLZb14Dq2x

Jun 22, 2021 · 892 followers View post →
João Conde
@CNanolab · X

Amazing study published ⁦@natBME⁩ by ⁦@DoloffLab⁩ and Langer Lab and co-workers ⁦@MIT⁩. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans | Nature Biomedical Engineering https://t.co/GU8SNMeNrk

Jun 22, 2021 · 8 likes · 1 share · 2,548 followers View post →
Malia McAvoy MD MSc
@MaliaMcavoy · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 641 followers View post →
Jess Frith
@Frithlab · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 1,181 followers View post →
Suzanne Thomson
@SuzEThomson · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 1,172 followers View post →
Pia Benedikt-Kühnast
@PiaBenedikt · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 287 followers View post →
Ramesh Subbiah PhD / இரமேசுப்பையா
@ramysubbiah · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 340 followers View post →
Cyrus Ghajar
@GhajarLab · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 2,188 followers View post →
Cancer at Nature Portfolio
@NatResCancer · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 6,064 followers View post →
Sarah Y Neshat
@sarahyneshat · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 595 followers View post →
Rachel Kratofil
@rachelkratofil · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 1,424 followers View post →
Palmarine128
@Palmarine128 · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 15,037 followers View post →
Yaw Ansong Snr
@YawAnsongSnr · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 229 followers View post →
Benjamin Keselowsky
@keselowsky · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 2,321 followers View post →
Omid Veiseh
@veiseho · X

RT @natBME: The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co…

Jun 21, 2021 · 16 shares · 3,487 followers View post →
Nature Biomedical Engineering
@natBME · X

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans https://t.co/GGSlUgGnob https://t.co/Ym8u4xIN0d

Jun 21, 2021 · 49 likes · 16 shares · 52,401 followers View post →