A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike variant with enhanced cytopathic and fusogenic effects. @mBioJournal https://t.co/RaQT3X44zA https://t.co/u3DAHzNAXW
Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.
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Jun 2021 – Nov 2023Where it's discussed
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X / Twitter8 posts
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YouTube2 videos
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What people are saying
Participants demonstrate high interest through specific references to the truncation of the spike protein and its effects, such as 'a C-terminal truncation of the spike protein' and 'enhanced cytopathic and fusogenic effects,' showing detailed engagement. The tone combines scientific commentary with casual phrases like 'what doesn't kill you mutates and tries again,' indicating both analytical and casual engagement, which supports the scores of moderate agreement and impact but high interest.
Most discussions acknowledge the significance of the study, highlighting the mutation and its effects, indicating general support or recognition of its importance.
The discussions are engaging, with users referencing detailed aspects of the research and its implications, showing strong curiosity about viral evolution.
Participants actively comment, with some providing additional insights or interpretations, reflecting meaningful involvement beyond surface-level interest.
The discussions suggest the study's findings are considered impactful, especially in understanding viral adaptation and potential disease severity, though not universally perceived as groundbreaking.
Abstract in brief
- SARS-CoV-2 is constantly evolving, with genetic variations arising from replication errors and host factors, leading to diversity in infected individuals.
- High-throughput sequencing of samples from over 15,000 infected individuals revealed recurrent mutations, particularly a notable variant of the viral spike (S) protein that lacks the last 20 amino acids, known as SΔ20.
- This truncated S protein may enhance viral cell fusion and contribute to disease effects within the host, highlighting a unique evolutionary pathway not primarily focused on transmission between hosts but on adaptations that affect disease severity.
Top posts
Most liked on X and BlueskyIdentification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/oTEf0YliTs https://t.co/lEko3kJM0R
@marcfavell @Anto_Berto @fitterhappierAJ I think I have a better summary: "What doesn't kill you mutates and tries again." https://t.co/viz9IUlBf5
New article: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/OXyK7ensbt #coronavirus #COVID19 #2019ncov https://t.co/OwAIGPem8X
RT @mbiojournal: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https…
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@marcfavell @Anto_Berto @fitterhappierAJ I think I have a better summary: "What doesn't kill you mutates and tries again." https://t.co/viz9IUlBf5
RT @mbiojournal: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https…
Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/oTEf0YliTs https://t.co/lEko3kJM0R
RT @ASMicrobiology: A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike…
A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike variant with enhanced cytopathic and fusogenic effects. @mBioJournal https://t.co/RaQT3X44zA https://t.co/u3DAHzNAXW
Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/aA23I9qpr2
New article: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/OXyK7ensbt #coronavirus #COVID19 #2019ncov https://t.co/OwAIGPem8X
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