June 2021 PMID 34182784

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.

Lynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M Stewart, Abdulhamid O Mohamud, Marceline Côté, Patrick M Giguère, Marc-André Langlois, Martin Pelchat

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Mentions

10
Peak: 6 in Jul 2021
across 2 sources since Jun 2021

Extended reach

120,993
potential audience

Total likes

27

Video views

213

Mentions per month

Jun 2021 – Nov 2023

Where it's discussed

  • X / Twitter8 posts
  • YouTube2 videos

AI synopsis

What people are saying

Participants demonstrate high interest through specific references to the truncation of the spike protein and its effects, such as 'a C-terminal truncation of the spike protein' and 'enhanced cytopathic and fusogenic effects,' showing detailed engagement. The tone combines scientific commentary with casual phrases like 'what doesn't kill you mutates and tries again,' indicating both analytical and casual engagement, which supports the scores of moderate agreement and impact but high interest.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, highlighting the mutation and its effects, indicating general support or recognition of its importance.

InterestHigh interest

The discussions are engaging, with users referencing detailed aspects of the research and its implications, showing strong curiosity about viral evolution.

EngagementModerate engagement

Participants actively comment, with some providing additional insights or interpretations, reflecting meaningful involvement beyond surface-level interest.

ImpactModerate impact

The discussions suggest the study's findings are considered impactful, especially in understanding viral adaptation and potential disease severity, though not universally perceived as groundbreaking.

Abstract in brief

  • SARS-CoV-2 is constantly evolving, with genetic variations arising from replication errors and host factors, leading to diversity in infected individuals.
  • High-throughput sequencing of samples from over 15,000 infected individuals revealed recurrent mutations, particularly a notable variant of the viral spike (S) protein that lacks the last 20 amino acids, known as SΔ20.
  • This truncated S protein may enhance viral cell fusion and contribute to disease effects within the host, highlighting a unique evolutionary pathway not primarily focused on transmission between hosts but on adaptations that affect disease severity.

Top posts

Most liked on X and Bluesky
ASM
@ASMicrobiology · X

A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike variant with enhanced cytopathic and fusogenic effects. @mBioJournal https://t.co/RaQT3X44zA https://t.co/u3DAHzNAXW

Jul 9, 2021 · 12 likes · 2 shares · 91,182 followers View post →
mBio
@mbiojournal · X

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/oTEf0YliTs https://t.co/lEko3kJM0R

Jul 9, 2021 · 7 likes · 2 shares · 27,177 followers View post →
Nguyễn Chí-Thanh
@chithanh_ · X

@marcfavell @Anto_Berto @fitterhappierAJ I think I have a better summary: "What doesn't kill you mutates and tries again." https://t.co/viz9IUlBf5

Nov 5, 2023 · 1 like · 203 followers View post →
Medical Zirigoza Group
@GroupZirigoza · X

Jun 30, 2021 · 1,540 followers View post →
NFTdose
@PaperbirdsH · X

New article: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/OXyK7ensbt #coronavirus #COVID19 #2019ncov https://t.co/OwAIGPem8X

Jun 29, 2021 · 301 followers View post →
Matsuura Laboratory / ウイルス制御学グループ
@Matsuura_Lab · X

RT @mbiojournal: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https…

Jul 9, 2021 · 2 shares · 266 followers View post →

All mentions

Nguyễn Chí-Thanh
@chithanh_ · X

@marcfavell @Anto_Berto @fitterhappierAJ I think I have a better summary: "What doesn't kill you mutates and tries again." https://t.co/viz9IUlBf5

Nov 5, 2023 · 1 like · 203 followers View post →
Matsuura Laboratory / ウイルス制御学グループ
@Matsuura_Lab · X

RT @mbiojournal: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https…

Jul 9, 2021 · 2 shares · 266 followers View post →
mBio
@mbiojournal · X

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/oTEf0YliTs https://t.co/lEko3kJM0R

Jul 9, 2021 · 7 likes · 2 shares · 27,177 followers View post →
Jose R Perez-Jimenez
@primer_ut · X

RT @ASMicrobiology: A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike…

Jul 9, 2021 · 2 shares · 82 followers View post →
ASM
@ASMicrobiology · X

A C-terminal truncation of the SARS-CoV-2 spike protein removes an important ER retention signal and results in a spike variant with enhanced cytopathic and fusogenic effects. @mBioJournal https://t.co/RaQT3X44zA https://t.co/u3DAHzNAXW

Jul 9, 2021 · 12 likes · 2 shares · 91,182 followers View post →
Medical Zirigoza Group
@GroupZirigoza · X

Jun 30, 2021 · 1,540 followers View post →
COVID19BrainPapers
@CoVbrain_papers · X

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/aA23I9qpr2

Jun 29, 2021 · 14 followers View post →
NFTdose
@PaperbirdsH · X

New article: Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects https://t.co/OXyK7ensbt #coronavirus #COVID19 #2019ncov https://t.co/OwAIGPem8X

Jun 29, 2021 · 301 followers View post →