Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/oHr7m628fV #PPD
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.
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Jun 2021 – Apr 2025Where it's discussed
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News90 articles
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What people are saying
The discussions highlight crucial elements such as the effectiveness of zuranolone over placebo, with phrases like 'game-changer' and 'miracle medication' reflecting enthusiasm and positive expectations. Comments surrounding its effectiveness and the anticipation of its role in treatment indicate that users are using language that conveys hope and urgency, emphasizing the potential for zuranolone to alter treatment approaches for postpartum depression.
Many discussions express a favorable view of zuranolone, suggesting a general consensus that it shows promise for postpartum depression treatment.
The discussions indicate a high level of curiosity regarding the publication and its implications for treating postpartum depression.
Several posts delve into specific details, including trial results and methodologies, reflecting a moderate depth of engagement.
There's a strong perception that zuranolone could significantly impact the treatment landscape for postpartum depression.
Abstract in brief
- Postpartum depression (PPD) is a prevalent medical issue affecting mothers and their children, leading to the need for effective treatments.*
- A phase 3 clinical trial tested zuranolone, a new drug, by comparing its effects to a placebo on women with PPD over a 2-week period.*
- Results showed that zuranolone significantly reduced depression scores compared to placebo, indicating its potential efficacy and safety for treating PPD.*
Top posts
Most liked on X and BlueskyEl uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clínico doble ciego asignado al azar. n= 153. https://t.co/PSk2oviffc https://t.co/WTDRdzP1qw
Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team. #PPD https://t.co/aKnNcFhVvW
案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論 RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産後うつ病 vs zuranolone https://t.co/JGTaMJDske
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network https://t.co/PvKsfDB2Ot
Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U
All mentions
Zuranolone: Innovative Treatment for Postpartum Depression
In this video, we delve into zuranolone and its revolutionary impact on postpartum depression (PPD) treatment. A phase 3 clinical trial demonstrated its efficacy in significantly reducing depression scores compared to…
Hormones and Their Role in Postpartum Depression Treatment
Approximately 10-15% of mothers experience postpartum depression. This video focuses on how hormonal changes after birth can influence this condition, highlighting the potential benefits of natural estradiol and…
RT @BiwakoHPDr: 案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論 RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産…
案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論 RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産後うつ病 vs zuranolone https://t.co/JGTaMJDske
Discover the game-changer in postpartum depression treatment: Zuranolone.
The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all AAPP members. https://t.co/dSxcfGcXHL https://t.co/BwAnga5Nxw
Effect of Zuranolone vs Placebo in Postpartum Depression https://t.co/NkGncCSxho Zuranolone for the Treatment of Postpartum Depression | American Journal of Psychiatry https://t.co/EJGb6jfgOX
@walidgellad The effect size in PPD is large (just past the border of medium and large). And there are no other good options available. What are you talking about? https://t.co/U1UTwhi3Sn And 40% of births do not result in PPD.
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial https://t.co/TE8gxz4hz8
@RecoveryDoctor @sanilrege And -4 points at day 15 : https://t.co/M3Nmy2gbLF
@chrisjamesdubey Is this a clinically meaningful difference from placebo? Zuranolone demonstrated significant day 15 HAMD-17 score improvements from baseline vs placebo (−17.8 vs −13.6; difference, −4.2; 95% CI, −6.9 to −1.5; P = .003) https://t.co/o53qZ6mRKQ
RT @GentleBirth: New 'miracle' PND medication - #zuranolone https://t.co/mS6Z06u7WM (doesn't seem to be breastfeeding friendly). #depress…
The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all CPNP members. https://t.co/LGvlgKd6y4 https://t.co/S7VjzQb7Fs
New 'miracle' PND medication - #zuranolone https://t.co/mS6Z06u7WM (doesn't seem to be breastfeeding friendly). #depression #postpartum #mentalhealth
The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all CPNP members. https://t.co/6SxJpmKYXK https://t.co/2zTWHfja2R
It had a successful phase III RCT, appears to be effective, possibly with a better side-effect profile than brexanolone. https://t.co/kDtlStXmeH
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial - PubMed https://t.co/wpPWZOR7et
RT @sminaev2015: Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychi…
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network https://t.co/PvKsfDB2Ot
New class of depression drugs being tested by Sage/Biogen for postpartum depression. Spoiler: 2 week of drug reduces depression thru 45 days. But the headline could be “placebo” is effective & has no side effects. & yes active drug does a little better. https://t.co/zWrVvrN8mo
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team. #PPD https://t.co/aKnNcFhVvW
RT @psychopharmacol: RCT: Zuranolone demonstrated improvements in HAMD scores vs placebo at day 15 in women with postpartum depression (MD=…
RCT: Zuranolone demonstrated improvements in HAMD scores vs placebo at day 15 in women with postpartum depression (MD= −4.2; −6.9 to −1.5). Response and remission rates were higher with zuranolone (OR=2.63; 1.34-5.16 and 2.53; 1.24-5.17, respectively) https://t.co/4ClzhjwMmD https://t.co/ha01MitrTc
Effect of Zuranolone vs Placebo in Postpartum Depression - JAMA Psychiatry via BrainSights for iOS https://t.co/KWwonjTGlH
La Zuranolona tiene una farmacocinética similar a la brexanolona, ser un modulador alostérico positivo del receptor GABAa. Hasta ahora con resultados favorables para tratar la #depresión posparto. #Saludmental #Psiquiatría https://t.co/ib0MkoxVDY
Postpartum depression (PPD) affects ~13% of American women according to a @JAMANetwork article: https://t.co/0QhfAATai4. Zuranolone has generated significant symptom reduction in women with PPD in a trial. For help with PPD, call 212-939-7200 or visit https://t.co/ff5twTCFMi. https://t.co/oTZp3SSyoj
Zuranolone mejoraría los síntomas nucleares de la depresión en mujeres y sería bien tolerado https://t.co/ujQwp3iamF a través de @JAMAPsych part of @JAMANetwork
Effect of Zuranolone vs Placebo in Postpartum Depression https://t.co/ePUSvPgQoD via @JAMAPsych part of @JAMANetwork
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network 産後うつ病に対するズラノロン vs. プラセボ https://t.co/KaTOdy8tRx
Zuranolone, a novel antidepressant working as a synthetic neurosteroid and positive allosteric modulator of GABAa, shows good results in phase III trials for postpartum depression: https://t.co/A43cEq3Eal
Our latest Depression & Anxiety bulletin: Care farms, can they help with depression, anxiety and quality of life?; Effect of Zuranolone vs Placebo in Postpartum Depression - A Randomized Clinical Trial; & more https://t.co/BkZYAY3HgB
RT @GlobalMedEd: #Zuranolone a novel oral antidepressant improved symptoms of #postpartum depression within 3 days in a controlled trial. h…
#Zuranolone a novel oral antidepressant improved symptoms of #postpartum depression within 3 days in a controlled trial. https://t.co/l8qHRdCirE #nursepractitioner #mentalhealth #psychiatry #mhchat #mh #medicine #primarycare #depression #anxiety #bipolar
RT @Luke_629: Effect of #Zuranolone vs Placebo in #Postpartum #Depression https://t.co/Kedo64cav1 via @JAMAPsych part of @JAMANetwork
RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…
RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…
RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…
El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clínico doble ciego asignado al azar. n= 153. https://t.co/PSk2oviffc https://t.co/WTDRdzP1qw
RT @fbwill_williams: Zuranolone effective in treating #postpartumdepression in a well-designed phase 3 #RCT - Effective onset after just 3…
Zuranolone effective in treating #postpartumdepression in a well-designed phase 3 #RCT - Effective onset after just 3 days of therapy - Enduring benefit at day 45 despite just two weeks of nightly treatment @neel_shah @IlinaMD @MichaelMAzizMD1 @MySMFM https://t.co/PhtCZDeme6
RCT: Zuranolone, a positive allosteric modulator of GABA r., improved depression in women with PPD vs placebo (MD [HAMD]= −4.2; −6.9 to −1.5). Response and remission rates at day 15 favored zuranolone (OR=2.63; 1.34-5.16 & 2.53; 1.24-5.17, respectively) https://t.co/4ClzhjfaY3 https://t.co/DV8y9rqbNm
Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/lyynxX9I19 #PPD https://t.co/o4mFPT8Uya
RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U
RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U
RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U
Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U
Effect of #Zuranolone vs Placebo in #Postpartum #Depression https://t.co/Kedo64cav1 via @JAMAPsych part of @JAMANetwork
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
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RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…
Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/oHr7m628fV #PPD