JAMA Psychiatry September 2021 PMID 34190962

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.

Kristina M Deligiannidis, Samantha Meltzer-Brody, Handan Gunduz-Bruce, James Doherty, Jeffrey Jonas, Sigui Li, Abdul J Sankoh, Christopher Silber, Andrew D Campbell, Brian Werneburg, Stephen J Kanes, Robert Lasser

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Mentions

161
Peak: 19 in Jul 2021
across 6 sources since Jun 2021

Extended reach

381,442
potential audience

Total likes

163

Video views

1,488

Mentions per month

Jun 2021 – Apr 2025

Where it's discussed

  • News90 articles
  • X / Twitter58 posts
  • Blogs6 articles
  • Reddit3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions highlight crucial elements such as the effectiveness of zuranolone over placebo, with phrases like 'game-changer' and 'miracle medication' reflecting enthusiasm and positive expectations. Comments surrounding its effectiveness and the anticipation of its role in treatment indicate that users are using language that conveys hope and urgency, emphasizing the potential for zuranolone to alter treatment approaches for postpartum depression.

AgreementModerate agreement

Many discussions express a favorable view of zuranolone, suggesting a general consensus that it shows promise for postpartum depression treatment.

InterestHigh interest

The discussions indicate a high level of curiosity regarding the publication and its implications for treating postpartum depression.

EngagementModerate engagement

Several posts delve into specific details, including trial results and methodologies, reflecting a moderate depth of engagement.

ImpactHigh impact

There's a strong perception that zuranolone could significantly impact the treatment landscape for postpartum depression.

Abstract in brief

  • Postpartum depression (PPD) is a prevalent medical issue affecting mothers and their children, leading to the need for effective treatments.*
  • A phase 3 clinical trial tested zuranolone, a new drug, by comparing its effects to a placebo on women with PPD over a 2-week period.*
  • Results showed that zuranolone significantly reduced depression scores compared to placebo, indicating its potential efficacy and safety for treating PPD.*

Top posts

Most liked on X and Bluesky
JAMA Psychiatry
@JAMAPsych · X

Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/oHr7m628fV #PPD

Jun 30, 2021 · 45 likes · 18 shares · 56,697 followers View post →
Ramiro Esparza
@docramiro · X

El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clínico doble ciego asignado al azar. n= 153. https://t.co/PSk2oviffc https://t.co/WTDRdzP1qw

Jul 2, 2021 · 17 likes · 4 shares · 68,314 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team. #PPD https://t.co/aKnNcFhVvW

Sep 6, 2021 · 16 likes · 9 shares · 56,697 followers View post →
稲垣貴彦@精神科医だった人
@BiwakoHPDr · X

案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論  RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産後うつ病 vs zuranolone https://t.co/JGTaMJDske

May 29, 2024 · 13 likes · 1 share · 5,185 followers View post →
Sergey Minaev
@sminaev2015 · X

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network https://t.co/PvKsfDB2Ot

Dec 2, 2021 · 8 likes · 1 share · 31,471 followers View post →
Tory Eisenlohr-Moul, PhD (CLEAR Lab)
@eisenlohr_moul · X

Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U

Jun 30, 2021 · 4 likes · 3 shares · 5,036 followers View post →

All mentions

ほねたらこ
@lifelog_hone · X

RT @BiwakoHPDr: 案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論  RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産…

May 29, 2024 · 1 share · 43 followers View post →
稲垣貴彦@精神科医だった人
@BiwakoHPDr · X

案外誰も話題にしないんだけど、RCTでプラセボでどれくらいの人が良くなるんだ?と思って調べてみたのです。 結論  RCTでは負けてるけど、効く人には効くよ。俺効いたことあるし。 とか言うふざけた人。 砂糖でも塩でも効く人には効きますから。 産後うつ病 vs zuranolone https://t.co/JGTaMJDske

May 29, 2024 · 13 likes · 1 share · 5,185 followers View post →
Pharmacology Insights
@PharmacoIns · X

Discover the game-changer in postpartum depression treatment: Zuranolone.

Apr 23, 2024 · 1 like · 11 followers View post →
AAPP
@psychpharm · X

The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all AAPP members. https://t.co/dSxcfGcXHL https://t.co/BwAnga5Nxw

Oct 13, 2023 · 2 likes · 968 followers View post →
Daiki Hiraoka
@izumi_bane · X

Effect of Zuranolone vs Placebo in Postpartum Depression https://t.co/NkGncCSxho Zuranolone for the Treatment of Postpartum Depression | American Journal of Psychiatry https://t.co/EJGb6jfgOX

Aug 19, 2023 · 133 followers View post →
BiotechObserver
@BiotechObserver · X

@walidgellad The effect size in PPD is large (just past the border of medium and large). And there are no other good options available. What are you talking about? https://t.co/U1UTwhi3Sn And 40% of births do not result in PPD.

Aug 8, 2023 · 2,806 followers View post →
Anna Bonet Esteve
@annabonet · X

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial https://t.co/TE8gxz4hz8

Aug 6, 2023 · 913 followers View post →
Florian Naudet
@NaudetFlorian · X

@RecoveryDoctor @sanilrege And -4 points at day 15 : https://t.co/M3Nmy2gbLF

Aug 6, 2023 · 2 likes · 1 share · 2,544 followers View post →
Informed Consent Matters
@stopharmingus · X

@chrisjamesdubey Is this a clinically meaningful difference from placebo? Zuranolone demonstrated significant day 15 HAMD-17 score improvements from baseline vs placebo (−17.8 vs −13.6; difference, −4.2; 95% CI, −6.9 to −1.5; P = .003) https://t.co/o53qZ6mRKQ

Aug 5, 2023 · 1 like · 1,826 followers View post →
$feth whale
@stockmaster1948 · X

RT @GentleBirth: New 'miracle' PND medication - #zuranolone https://t.co/mS6Z06u7WM (doesn't seem to be breastfeeding friendly). #depress…

Jul 25, 2023 · 1 share · 832 followers View post →
AAPP
@psychpharm · X

The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all CPNP members. https://t.co/LGvlgKd6y4 https://t.co/S7VjzQb7Fs

Jul 24, 2023 · 968 followers View post →
GentleBirth
@GentleBirth · X

New 'miracle' PND medication - #zuranolone https://t.co/mS6Z06u7WM (doesn't seem to be breastfeeding friendly). #depression #postpartum #mentalhealth

Jul 11, 2023 · 1 like · 1 share · 7,931 followers View post →
AAPP
@psychpharm · X

The 1/21/2022 #JournalClub presented "Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial". The recording is available free to all CPNP members. https://t.co/6SxJpmKYXK https://t.co/2zTWHfja2R

Aug 25, 2022 · 968 followers View post →
Thomas Reilly
@Rational_Psych · X

It had a successful phase III RCT, appears to be effective, possibly with a better side-effect profile than brexanolone. https://t.co/kDtlStXmeH

Jun 13, 2022 · 1,287 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial - PubMed https://t.co/wpPWZOR7et

Apr 11, 2022 · 1,014 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @sminaev2015: Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychi…

Dec 2, 2021 · 1 share · 31,471 followers View post →
Sergey Minaev
@sminaev2015 · X

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network https://t.co/PvKsfDB2Ot

Dec 2, 2021 · 8 likes · 1 share · 31,471 followers View post →
Mini Maninder Kahlon
@mkahlon · X

New class of depression drugs being tested by Sage/Biogen for postpartum depression. Spoiler: 2 week of drug reduces depression thru 45 days. But the headline could be “placebo” is effective & has no side effects. & yes active drug does a little better. https://t.co/zWrVvrN8mo

Sep 6, 2021 · 1 like · 717 followers View post →
Bengü Yücens
@BYucens · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Sep 6, 2021 · 9 shares · 68 followers View post →
Dr Gemma Lewis
@GemmaLewis13 · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Sep 6, 2021 · 9 shares · 1,766 followers View post →
Verónica VQuer
@VeronicaVquer · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Sep 6, 2021 · 9 shares · 1 followers View post →
Dr danish hussain
@danish0318 · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Sep 6, 2021 · 9 shares · 38 followers View post →
Prof Miranda Wolpert
@mirandarwolpert · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Sep 6, 2021 · 9 shares · 10,849 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team. #PPD https://t.co/aKnNcFhVvW

Sep 6, 2021 · 16 likes · 9 shares · 56,697 followers View post →
NeuroPsiqMex
@MexPsiq · X

RT @psychopharmacol: RCT: Zuranolone demonstrated improvements in HAMD scores vs placebo at day 15 in women with postpartum depression (MD=…

Sep 5, 2021 · 1 share · 1,046 followers View post →
P
@psychopharmacol · X

RCT: Zuranolone demonstrated improvements in HAMD scores vs placebo at day 15 in women with postpartum depression (MD= −4.2; −6.9 to −1.5). Response and remission rates were higher with zuranolone (OR=2.63; 1.34-5.16 and 2.53; 1.24-5.17, respectively) https://t.co/4ClzhjwMmD https://t.co/ha01MitrTc

Sep 5, 2021 · 1 share · 575 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Effect of Zuranolone vs Placebo in Postpartum Depression - JAMA Psychiatry via BrainSights for iOS https://t.co/KWwonjTGlH

Sep 1, 2021 · 313 followers View post →
El Paido ®️
@ElPaido · X

La Zuranolona tiene una farmacocinética similar a la brexanolona, ser un modulador alostérico positivo del receptor GABAa. Hasta ahora con resultados favorables para tratar la #depresión posparto. #Saludmental #Psiquiatría https://t.co/ib0MkoxVDY

Jul 28, 2021 · 2 likes · 12,791 followers View post →
Seleni Institute
@selenidotorg · X

Postpartum depression (PPD) affects ~13% of American women according to a @JAMANetwork article: https://t.co/0QhfAATai4. Zuranolone has generated significant symptom reduction in women with PPD in a trial. For help with PPD, call 212-939-7200 or visit https://t.co/ff5twTCFMi. https://t.co/oTZp3SSyoj

Jul 20, 2021 · 2,207 followers View post →
@investigando
@rocatanho · X

Zuranolone mejoraría los síntomas nucleares de la depresión en mujeres y sería bien tolerado https://t.co/ujQwp3iamF a través de @JAMAPsych part of @JAMANetwork

Jul 19, 2021 · 400 followers View post →
Rebecca Sripada, PhD
@Rebecca_Sripada · X

Effect of Zuranolone vs Placebo in Postpartum Depression https://t.co/ePUSvPgQoD via @JAMAPsych part of @JAMANetwork

Jul 18, 2021 · 785 followers View post →
猫になりたい薬剤師
@Vannyamoto · X

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial | Depressive Disorders | JAMA Psychiatry | JAMA Network 産後うつ病に対するズラノロン vs. プラセボ https://t.co/KaTOdy8tRx

Jul 14, 2021 · 1,042 followers View post →
Progress
@progressnp · X

Zuranolone, a novel antidepressant working as a synthetic neurosteroid and positive allosteric modulator of GABAa, shows good results in phase III trials for postpartum depression: https://t.co/A43cEq3Eal

Jul 10, 2021 · 203 followers View post →
Evidently Better
@EvidentlyBetter · X

Our latest Depression & Anxiety bulletin: Care farms, can they help with depression, anxiety and quality of life?; Effect of Zuranolone vs Placebo in Postpartum Depression - A Randomized Clinical Trial; & more https://t.co/BkZYAY3HgB

Jul 9, 2021 · 624 followers View post →
R. A Martin, Jr.
@DJROSTI · X

RT @GlobalMedEd: #Zuranolone a novel oral antidepressant improved symptoms of #postpartum depression within 3 days in a controlled trial. h…

Jul 7, 2021 · 1 share · 5,846 followers View post →
Global Med Education
@GlobalMedEd · X

#Zuranolone a novel oral antidepressant improved symptoms of #postpartum depression within 3 days in a controlled trial. https://t.co/l8qHRdCirE #nursepractitioner #mentalhealth #psychiatry #mhchat #mh #medicine #primarycare #depression #anxiety #bipolar

Jul 7, 2021 · 3 likes · 1 share · 9,293 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

RT @Luke_629: Effect of #Zuranolone vs Placebo in #Postpartum #Depression https://t.co/Kedo64cav1 via @JAMAPsych part of @JAMANetwork

Jul 4, 2021 · 1 share · 2,288 followers View post →
Doctortips_5
@Doctortips_5 · X

RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…

Jul 3, 2021 · 4 shares · 469 followers View post →
MIRIAM
@LADOMINA · X

RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…

Jul 2, 2021 · 4 shares · 38 followers View post →
Alizolam
@MissAcaciia · X

RT @docramiro: El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clí…

Jul 2, 2021 · 4 shares · 1,461 followers View post →
Ramiro Esparza
@docramiro · X

El uso de Zuranolona mostró mejoría en mujeres con depresión postparto y fue bien tolerado comparado con placebo. Ensayo clínico doble ciego asignado al azar. n= 153. https://t.co/PSk2oviffc https://t.co/WTDRdzP1qw

Jul 2, 2021 · 17 likes · 4 shares · 68,314 followers View post →
Michael M Aziz, MD MPH
@MichaelMAzizMD1 · X

RT @fbwill_williams: Zuranolone effective in treating #postpartumdepression in a well-designed phase 3 #RCT - Effective onset after just 3…

Jul 2, 2021 · 2 shares · 882 followers View post →
F. B. Will Williams
@fbwill_williams · X

Zuranolone effective in treating #postpartumdepression in a well-designed phase 3 #RCT - Effective onset after just 3 days of therapy - Enduring benefit at day 45 despite just two weeks of nightly treatment @neel_shah @IlinaMD @MichaelMAzizMD1 @MySMFM https://t.co/PhtCZDeme6

Jul 2, 2021 · 3 likes · 2 shares · 2,437 followers View post →
P
@psychopharmacol · X

RCT: Zuranolone, a positive allosteric modulator of GABA r., improved depression in women with PPD vs placebo (MD [HAMD]= −4.2; −6.9 to −1.5). Response and remission rates at day 15 favored zuranolone (OR=2.63; 1.34-5.16 & 2.53; 1.24-5.17, respectively) https://t.co/4ClzhjfaY3 https://t.co/DV8y9rqbNm

Jul 1, 2021 · 1 like · 575 followers View post →
Dra. Teraiza Mesa R Cuenta Oficial ®
@Dra_TeraizaMesa · X

Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/lyynxX9I19 #PPD https://t.co/o4mFPT8Uya

Jul 1, 2021 · 9,066 followers View post →
BiAffect
@BiAffect · X

RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U

Jul 1, 2021 · 3 shares · 501 followers View post →
Nicole Petersen
@tweetnicolepete · X

RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U

Jun 30, 2021 · 3 shares · 624 followers View post →
Audrey Hepburn she/her
@ciaoalleb · X

RT @eisenlohr_moul: Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U

Jun 30, 2021 · 3 shares · 539 followers View post →
Tory Eisenlohr-Moul, PhD (CLEAR Lab)
@eisenlohr_moul · X

Exciting to see new neurosteroid treatments coming down the pipeline! https://t.co/LpfBZo6L4U

Jun 30, 2021 · 4 likes · 3 shares · 5,036 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

Effect of #Zuranolone vs Placebo in #Postpartum #Depression https://t.co/Kedo64cav1 via @JAMAPsych part of @JAMANetwork

Jun 30, 2021 · 2 likes · 1 share · 2,288 followers View post →
SEPSM
@SEPsiq · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 5,681 followers View post →
Psiquiatria Infantil
@PsiqInfantil · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 4,105 followers View post →
Tam
@tamahara93 · X

Article of the day

Jun 30, 2021 · 2 likes · 244 followers View post →
Zucker Hillside Psychiatric Neuroscience
@zhhresearch · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 559 followers View post →
John Torous, MD MBI
@JohnTorousMD · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 9,497 followers View post →
Prof Miranda Wolpert
@mirandarwolpert · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 10,849 followers View post →
iBraiN Inserm Lab
@iBrain_Inserm · X

RT @JAMAPsych: Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe pos…

Jun 30, 2021 · 18 shares · 1,722 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Results from this new prospective randomized placebo-controlled trial of zuranolone suggest benefit in women with severe postpartum depression. From @zhhresearch team https://t.co/oHr7m628fV #PPD

Jun 30, 2021 · 45 likes · 18 shares · 56,697 followers View post →