Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/Esu2z924SF
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites.
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Jul 2021 – Oct 2022Where it's discussed
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X / Twitter55 posts
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AI synopsis
What people are saying
Discussions often praise the research as a 'brilliant' example of how genome defense can evolve through domain shuffling, with phrases like 'fantastic co-option story' and references to the significance of the chimeric nuclease, reflecting a high level of interest and recognition of its potential impact.
Most discussions highlight admiration for the innovative discovery, affirming the importance of the research in advancing understanding of phage defense mechanisms.
Participants show high curiosity, frequently using words like 'brilliant', 'fantastic', and emphasizing the significance of domain shuffling and genome defense systems.
Many comments delve into details, referencing specific mechanisms like the chimeric nuclease, and engaging with ideas about evolutionary novelty.
The widespread positive tone and emphasis on the potential and significance of this gene editing strategy indicate perceived high impact on the field.
Abstract in brief
- A chimeric endonuclease in bacteriophages provides sequence-specific immunity against parasitic mobile elements called PLEs by binding and cleaving their origins of replication, especially in ICP1 phages lacking CRISPR-Cas systems.
- The endonuclease is of chimeric origin, combining a DNA-binding domain similar to PLE replication proteins with other functional parts, allowing it to target and cut PLE DNA.
- This discovery highlights how genome defense mechanisms can evolve through domain shuffling, influencing the genetic evolution and diversity of mobile genetic elements like PLEs and phages.
Top posts
Most liked on X and BlueskyHorizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/NczFccwYDk
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/EqcU7IjMPm
Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral pa… https://t.co/9cwSEi5R7O
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/zhgd74FJy0
ICP1 phage is brilliant enough to acquire a fully functional CRISPR-Cas system (https://t.co/0pvYIxeKvv) or a PLE-specific nuclease, Odn (https://t.co/5e0uvf71Ck). (6/n) https://t.co/cFyoCn3CMz
All mentions
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ICP1 phage is brilliant enough to acquire a fully functional CRISPR-Cas system (https://t.co/0pvYIxeKvv) or a PLE-specific nuclease, Odn (https://t.co/5e0uvf71Ck). (6/n) https://t.co/cFyoCn3CMz
New genome defence systems in bacteriophages can arise through domain shuffling https://t.co/yHcviaESaI
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYJfGQl
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/EqcU7IjMPm
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/zhgd74FJy0
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/NczFccwYDk
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYJfGQl
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites https://t.co/mOWXeTs4Xr
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYIY5YN
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/Esu2z924SF
RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…
RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…
RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…
RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…
Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral pa… https://t.co/9cwSEi5R7O
A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites https://t.co/ALg3VyNZJT
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