Elife July 2021 PMID 34232860

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites.

Zachary K Barth, Maria Ht Nguyen, Kimberley D Seed

Mentions

61
Peak: 23 in Aug 2021
across 4 sources since Jul 2021

Extended reach

788,458
potential audience

Total likes

164

Video views

213

Mentions per month

Jul 2021 – Oct 2022

Where it's discussed

  • X / Twitter55 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Discussions often praise the research as a 'brilliant' example of how genome defense can evolve through domain shuffling, with phrases like 'fantastic co-option story' and references to the significance of the chimeric nuclease, reflecting a high level of interest and recognition of its potential impact.

AgreementStrong agreement

Most discussions highlight admiration for the innovative discovery, affirming the importance of the research in advancing understanding of phage defense mechanisms.

InterestHigh interest

Participants show high curiosity, frequently using words like 'brilliant', 'fantastic', and emphasizing the significance of domain shuffling and genome defense systems.

EngagementHigh engagement

Many comments delve into details, referencing specific mechanisms like the chimeric nuclease, and engaging with ideas about evolutionary novelty.

ImpactHigh impact

The widespread positive tone and emphasis on the potential and significance of this gene editing strategy indicate perceived high impact on the field.

Abstract in brief

  • A chimeric endonuclease in bacteriophages provides sequence-specific immunity against parasitic mobile elements called PLEs by binding and cleaving their origins of replication, especially in ICP1 phages lacking CRISPR-Cas systems.
  • The endonuclease is of chimeric origin, combining a DNA-binding domain similar to PLE replication proteins with other functional parts, allowing it to target and cut PLE DNA.
  • This discovery highlights how genome defense mechanisms can evolve through domain shuffling, influencing the genetic evolution and diversity of mobile genetic elements like PLEs and phages.

Top posts

Most liked on X and Bluesky
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/Esu2z924SF

Aug 29, 2021 · 69 likes · 23 shares · 172,233 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/NczFccwYDk

Sep 11, 2021 · 30 likes · 7 shares · 172,233 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/EqcU7IjMPm

Nov 5, 2021 · 18 likes · 5 shares · 172,233 followers View post →
Joseph E. Peters
@JoePetersLab · X

Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral pa… https://t.co/9cwSEi5R7O

Jul 8, 2021 · 18 likes · 4 shares · 904 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/zhgd74FJy0

Sep 15, 2021 · 12 likes · 2 shares · 172,233 followers View post →
María Nguyễn
@MariaHTNguyen · X

ICP1 phage is brilliant enough to acquire a fully functional CRISPR-Cas system (https://t.co/0pvYIxeKvv) or a PLE-specific nuclease, Odn (https://t.co/5e0uvf71Ck). (6/n) https://t.co/cFyoCn3CMz

Oct 22, 2022 · 9 likes · 296 followers View post →

All mentions

María Nguyễn
@MariaHTNguyen · X

ICP1 phage is brilliant enough to acquire a fully functional CRISPR-Cas system (https://t.co/0pvYIxeKvv) or a PLE-specific nuclease, Odn (https://t.co/5e0uvf71Ck). (6/n) https://t.co/cFyoCn3CMz

Oct 22, 2022 · 9 likes · 296 followers View post →
Jose L. Oliver
@Jose_Oliver · X

New genome defence systems in bacteriophages can arise through domain shuffling https://t.co/yHcviaESaI

Nov 8, 2021 · 469 followers View post →
Apostolos Liakopoulos
@AposLiakopoulos · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Nov 6, 2021 · 5 shares · 958 followers View post →
Sheila Shin
@scshinyahoo · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Nov 6, 2021 · 5 shares · 3,558 followers View post →
Vasili Hauryliuk
@hauryliuk · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Nov 6, 2021 · 5 shares · 3,159 followers View post →
Fernando Gomollón
@fgomollon · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Nov 6, 2021 · 5 shares · 8,575 followers View post →
Maximilien "Mjolnir tosser" Guerrero
@Praetorian27 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Nov 5, 2021 · 5 shares · 1,171 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYJfGQl

Nov 5, 2021 · 885 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/EqcU7IjMPm

Nov 5, 2021 · 18 likes · 5 shares · 172,233 followers View post →
Eskom Expo for Young Scientists
@Exposcience · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 16, 2021 · 2 shares · 10,061 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/zhgd74FJy0

Sep 15, 2021 · 12 likes · 2 shares · 172,233 followers View post →
Alexander Suh 서상재
@alexander_suh · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 12, 2021 · 7 shares · 4,368 followers View post →
Cedric
@CedricFeschotte · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 12, 2021 · 7 shares · 8,176 followers View post →
Mich Kitoi
@KitoiO · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 12, 2021 · 7 shares · 1,235 followers View post →
Ramakrishnan
@ramki17071993 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 12, 2021 · 7 shares · 344 followers View post →
María Nguyễn
@MariaHTNguyen · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 11, 2021 · 7 shares · 296 followers View post →
Michael Galindo
@Miyckoal · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 11, 2021 · 7 shares · 387 followers View post →
Jason Fernandes
@jdf_ev · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 11, 2021 · 7 shares · 714 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/NczFccwYDk

Sep 11, 2021 · 30 likes · 7 shares · 172,233 followers View post →
Toyota_Group_Komaba
@KomaToug · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 667 followers View post →
EGLlilly
@EGL_Lilly · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 24 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYJfGQl

Sep 5, 2021 · 885 followers View post →
Narendra meena
@Narendr00182699 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 348 followers View post →
Ankit Singla
@In_AnkitSingla · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 1,488 followers View post →
Eduardo Villalobo
@ptu_us_es · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 1,112 followers View post →
M Moniruzzaman
@giant_virus · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Sep 5, 2021 · 6 shares · 1,113 followers View post →
Kenneth Yaw Agyeman-Badu
@Kenzibit · X

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites https://t.co/mOWXeTs4Xr

Aug 31, 2021 · 1,626 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites | eLife https://t.co/o6QcYIY5YN

Aug 31, 2021 · 885 followers View post →
paula
@paula02067962 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 31, 2021 · 23 shares · 8 followers View post →
Vasili Hauryliuk
@hauryliuk · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 3,159 followers View post →
BiolocoUSB
@biolocousb · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 1,083 followers View post →
Xiaoqian(Annie) Yu
@seaweedomics · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 362 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 1,207 followers View post →
Dr.med. Bernd Kynast
@DrKynast · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 3,016 followers View post →
Aisylu Shaidullina
@AShaidullina1 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 479 followers View post →
Ann Gregory, PhD
@gregory_annc · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 1,597 followers View post →
Thomas Hackl
@th4ckl · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 791 followers View post →
Kenneth Yaw Agyeman-Badu
@Kenzibit · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 1,626 followers View post →
Dr. د. عبدالواحد الزهراني
@ralzahrani2020 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 30, 2021 · 23 shares · 4,371 followers View post →
ren”
@EB0YSWIFT · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 119 followers View post →
Toyota_Group_Komaba
@KomaToug · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 667 followers View post →
Rafa Pinilla-Redondo
@rafapinilla92 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 2,874 followers View post →
Alexander Harms
@AHarms485 · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 9,267 followers View post →
Laszlo Hobor
@LHobor · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 783 followers View post →
Ankit Singla
@In_AnkitSingla · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 1,488 followers View post →
Jose Antonio Silva
@neo_silva · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 1,849 followers View post →
Balint Z. Kacsoh
@BalintZKacsoh · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 3,226 followers View post →
John Kenten
@JohnKenten · X

RT @eLife: Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome paras…

Aug 29, 2021 · 23 shares · 576 followers View post →
eLife - the journal
@eLife · X

Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction, demonstrating that new genome defence systems can arise through domain shuffling https://t.co/ohoBMzg0k2 https://t.co/Esu2z924SF

Aug 29, 2021 · 69 likes · 23 shares · 172,233 followers View post →
Kim Seed
@KimDSeed · X

RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…

Jul 13, 2021 · 4 shares · 1,436 followers View post →
Michelle Davison
@drawnfromexp · X

RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…

Jul 8, 2021 · 4 shares · 131 followers View post →
Simon Roux
@simroux_virus · X

RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…

Jul 8, 2021 · 4 shares · 3,773 followers View post →
Jeffrey Cornuault
@CornuaultJeffr1 · X

RT @JoePetersLab: Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage C…

Jul 8, 2021 · 4 shares · 133 followers View post →
Joseph E. Peters
@JoePetersLab · X

Fantastic co-option story in mobile DNA from our Zach's work with @KimDSeed ... A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral pa… https://t.co/9cwSEi5R7O

Jul 8, 2021 · 18 likes · 4 shares · 904 followers View post →
micropapers
@micro_papers · X

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites https://t.co/ALg3VyNZJT

Jul 7, 2021 · 1 like · 331 followers View post →