Circulation September 2021 PMID 34255973

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.

Laurienne Edgar, Naveed Akbar, Adam T Braithwaite, Thomas Krausgruber, Héctor Gallart-Ayala, Jade Bailey, Alastair L Corbin, Tariq E Khoyratty, Joshua T Chai, Mohammad Alkhalil, André F Rendeiro, Klemen Ziberna, Ritu Arya, Thomas J Cahill, Christoph Bock

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Mentions

62
Peak: 30 in Jul 2021
across 6 sources since Jul 2021

Extended reach

287,411
potential audience

Total likes

3,671

Video views

120,303

Mentions per month

Jul 2021 – Mar 2025

Where it's discussed

  • X / Twitter43 posts
  • News8 articles
  • Blogs4 articles
  • Reddit3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The collection reflects a high level of agreement and interest, with posts emphasizing the importance of hyperglycemia in promoting immune changes that lead to artery disease, exemplified by phrases like 'promotes persistent proatherogenic characteristics' and 'epigenetic priming.' The use of scientific terminology and references to ongoing research indicate deep engagement and recognition of the study's potential impact on medical practices.

AgreementStrong agreement

Most discussions emphasize the significance of hyperglycemia's role in immune cell reprogramming and atherosclerosis, showing strong consensus with positive language.

InterestHigh interest

Posts demonstrate high interest through references to immunology, cardiovascular risk, and mentions of ongoing research, indicating enthusiasm and engagement with the topic.

EngagementModerate engagement

While many posts echo the study's findings, some include detailed quotes or calls to action, suggesting active engagement with the science rather than superficial comments.

ImpactHigh impact

The widespread sharing of the research and comments about its relevance to cardiovascular health imply that these discussions recognize the study's potential to influence medical understanding and future treatments.

Abstract in brief

  • Study investigates how high blood sugar (hyperglycemia) affects immune cells (macrophages) in diabetes, leading to an increased risk of cardiovascular disease.
  • Experiments using macrophages from diabetic mice showed they become "trained" to exhibit inflammatory behaviors even when glucose levels are normal, suggesting a lasting impact from prior high glucose exposure.
  • Bone marrow transplants from diabetic mice into healthy mice showed that this training can contribute to more severe artery disease, indicating that changes in immune cell behavior due to diabetes can promote ongoing cardiovascular issues.

Top posts

Most liked on X and Bluesky
Circulation
@CircAHA · X

Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after glucose normalization. Why glucose control alone may not be enough for #ASCVD risk reduction in #diabetes https://t.co/aFbvfB6LRZ #AHAJournals https://t.co/KyCqQWlXMv

Jul 15, 2021 · 76 likes · 25 shares · 77,376 followers View post →
Adam Braithwaite
@BraithwaiteAT · X

'Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis' (@CircAHA) A huge collaborative work to progress understanding of trained immunity associated with hyperglycaemia. Congratulations to all involved. https://t.co/h0HjIC863h https://t.co/onco8r4EcZ

Jul 16, 2021 · 11 likes · 96 followers View post →
Kristiaan Wouters
@Kristiaan24 · X

Sugar makes your macrophages remember! Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis: https://t.co/sYudQa91vF #diabetes #cardiovascular #macrophage

Sep 21, 2021 · 9 likes · 682 followers View post →
Laurienne Edgar
@EdgarLaurienne · X

After 7 years of hard work, Edgar & Akbar et al. is finally out for all to enjoy

Jul 15, 2021 · 5 likes · 27 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis @CircAHA https://t.co/50E9d8mI1e

Sep 25, 2021 · 3 likes · 6,435 followers View post →
Orsolya Szathmari
@orsolya_health · X

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/oE7otcW2oZ

Sep 21, 2021 · 3 likes · 1,622 followers View post →

All mentions

Tarun TejpaŁ
@TTejpal · X

This Works Better than Stem Cells - 5 Ways to Increase Stem Cells Naturally https://t.co/8IRuKdSZNa via @YouTube

Mar 10, 2025 · 1,679 followers View post →
To By For University
@OutDream · X

https://t.co/5VgLUaXP57

Mar 3, 2025 · 808 followers View post →
Perussuomalainen
@Perussuomalain1 · X

#Paasto stimuloi muuten kantasoluja! https://t.co/dRmDnG8mKz https://t.co/KfHJMC8L7k

Mar 3, 2025 · 71 followers View post →
Nathaniel Christopher
@gladenfern · X

https://t.co/wrTE9TRwb7

Mar 3, 2025 · 29 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

High blood sugar levels 'reprogram' stem cells https://t.co/EtjHDT4aIs https://t.co/p9u46ubJ5z https://t.co/t7xQbe1tF9

Oct 5, 2021 · 93 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis @CircAHA https://t.co/50E9d8mI1e

Sep 25, 2021 · 3 likes · 6,435 followers View post →
Circulation 日本版
@Circulation_nih · X

RT @CircAHA: ICYMI Hyperglycemia Induces Trained Immunity https://t.co/i7tqMegbnQ

Sep 24, 2021 · 3 shares · 345 followers View post →
@MTome
@DrMaiteTome · X

RT @CircAHA: ICYMI Hyperglycemia Induces Trained Immunity https://t.co/i7tqMegbnQ

Sep 22, 2021 · 3 shares · 869 followers View post →
Giuseppe Danilo Norata
@DaniloNorata · X

RT @CircAHA: ICYMI Hyperglycemia Induces Trained Immunity https://t.co/i7tqMegbnQ

Sep 22, 2021 · 3 shares · 322 followers View post →
Kristiaan Wouters
@Kristiaan24 · X

Sugar makes your macrophages remember! Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis: https://t.co/sYudQa91vF #diabetes #cardiovascular #macrophage

Sep 21, 2021 · 9 likes · 682 followers View post →
Orsolya Szathmari
@orsolya_health · X

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/oE7otcW2oZ

Sep 21, 2021 · 3 likes · 1,622 followers View post →
DiscoStew
@DiscoStew66 · X

RT @NicolaiWorm: "We hypothesized that #hyperglycemia induces trained immunity in macrophages, promoting persistent proatherogenic characte…

Sep 21, 2021 · 1 share · 10,799 followers View post →
Nicolai Worm
@NicolaiWorm · X

"We hypothesized that #hyperglycemia induces trained immunity in macrophages, promoting persistent proatherogenic characteristics." https://t.co/KDfnuSvD8r @lowcarbGP @davidludwigmd

Sep 21, 2021 · 3 likes · 1 share · 1,472 followers View post →
Austin Jeans
@jeansdoc61 · X

RT @JRockDataSci1: Hyperglycemia reprograms stem cells toward production of pro-inflammatory pro-atherogenic macrophages which may later be…

Jul 17, 2021 · 4 shares · 964 followers View post →
Ahmad_I
@khanabdoosh_ · X

RT @JRockDataSci1: Hyperglycemia reprograms stem cells toward production of pro-inflammatory pro-atherogenic macrophages which may later be…

Jul 17, 2021 · 4 shares · 116 followers View post →
Ivor Goodbody
@IvorGoodbody · X

"High levels of #glucose in the blood "reprogram" stem cells, leading to a lasting increase in the risk of developing dangerous #atherosclerosis." #heartdisease #bloodsugar https://t.co/kSqaxmROZx

Jul 17, 2021 · 2 likes · 1,890 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @JRockDataSci1: Hyperglycemia reprograms stem cells toward production of pro-inflammatory pro-atherogenic macrophages which may later be…

Jul 17, 2021 · 4 shares · 330 followers View post →
Jasmin Abd-el-Baki
@jasminabdelbaki · X

RT @JRockDataSci1: Hyperglycemia reprograms stem cells toward production of pro-inflammatory pro-atherogenic macrophages which may later be…

Jul 16, 2021 · 4 shares · 116 followers View post →
JRockDataSci
@JRockDataSci1 · X

Hyperglycemia reprograms stem cells toward production of pro-inflammatory pro-atherogenic macrophages which may later become foam cells. https://t.co/Qajzv6bd74 @PeterAttiaMD @BenBikmanPhD @DaveKeto @virtahealth @DrSarahHallberg @gerdosi

Jul 16, 2021 · 3 likes · 4 shares · 1 followers View post →
Adam Braithwaite
@BraithwaiteAT · X

'Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis' (@CircAHA) A huge collaborative work to progress understanding of trained immunity associated with hyperglycaemia. Congratulations to all involved. https://t.co/h0HjIC863h https://t.co/onco8r4EcZ

Jul 16, 2021 · 11 likes · 96 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 2,420 followers View post →
la.martinis ⏱
@carola_martinez · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 500 followers View post →
Narainrit Karuna
@narainrit_k · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 21 followers View post →
Eri Kato, MD, MPH, PhD
@EriKato71362632 · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 693 followers View post →
Dra. Asunción César
@AsuncionCesar · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 131 followers View post →
Manuel Gaxiola
@cardiogax · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 7,992 followers View post →
Prof.Thomas Pulinilkunnil
@tpulinil · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 1,081 followers View post →
Raicito
@2king3world · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 326 followers View post →
John P Erwin III MD MBA MACC (#BigPoppy )
@HeartOTXHeartMD · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 39,661 followers View post →
Center for Molecular Cardiology
@cmc_uzh · X

RT @CircAHA: Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after gl…

Jul 15, 2021 · 25 shares · 2,626 followers View post →
Circulation
@CircAHA · X

Hyperglycaemia promotes epigenetic priming of macrophage precursors & persistent pro-atherogenic characteristics even after glucose normalization. Why glucose control alone may not be enough for #ASCVD risk reduction in #diabetes https://t.co/aFbvfB6LRZ #AHAJournals https://t.co/KyCqQWlXMv

Jul 15, 2021 · 76 likes · 25 shares · 77,376 followers View post →
Laurienne Edgar
@EdgarLaurienne · X

After 7 years of hard work, Edgar & Akbar et al. is finally out for all to enjoy

Jul 15, 2021 · 5 likes · 27 followers View post →
Ariakas Enoreth
@Aenoreth · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/W8tT9YzCPo

Jul 15, 2021 · 1,005 followers View post →
NG20194
@NG20194 · X

@abledoc @AskDrShashank Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/vfCXqFmXRC

Jul 14, 2021 · 188 followers View post →
CureME~CFS
@Cure_ME_CFS · X

@exceedhergrasp1 @GemzME @Tweet_Nutrition @KendaRigdon Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/4sU6ZzlJYy

Jul 14, 2021 · 2 likes · 476 followers View post →
Dr Anthony Martin
@AMAinsight · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis | Circulation https://t.co/V8DTsmsCAf

Jul 14, 2021 · 913 followers View post →
CeMM Papers
@CeMM_papers · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/9dHMgH8XHM

Jul 14, 2021 · 1 like · 541 followers View post →
Shinya Goto
@sgoto4 · X

RT @sgoto4: Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/QNYmPMbhw…

Jul 14, 2021 · 1 share · 323 followers View post →
Shinya Goto
@sgoto4 · X

RT @sgoto4: Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/QNYmPMbhwb

Jul 14, 2021 · 1 share · 323 followers View post →
Shinya Goto
@sgoto4 · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/QNYmPMbhwb

Jul 14, 2021 · 2 likes · 1 share · 323 followers View post →
Shinya Goto
@sgoto4 · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/QNYmPMbhwb高血糖と動脈硬化の関連がわかるかな?

Jul 14, 2021 · 1 like · 1 share · 323 followers View post →
Malcolm Biranek
@mbiranek · X

https://t.co/NhokZ0vcJ7

Jul 14, 2021 · 328 followers View post →
Cardio-Targets
@CardioTargets · X

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis https://t.co/u3KzcxkXlh

Jul 14, 2021 · 153 followers View post →