Nat Commun July 2021 PMID 34312385

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.

David S Fischer, Meshal Ansari, Karolin I Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H Mayr, Maximilian Strunz, Niklas J Lang, Elvira D'Ippolito, Monika Hammel, Laura Mateyka, Simone Weber, Lisa S Wolff, Klaus Witter, Isis E Fernandez

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Mentions

Peak: 11 in Jul 2021

across 6 sources since Jul 2021

Extended reach

387,142

potential audience

Total likes

5,063

Video views

285,413

Mentions per month

Jul 2021 – Mar 2022

Where it's discussed

X / Twitter22 posts
News17 articles
YouTube2 videos
Facebook2 posts
Reddit2 posts
Blogs2 articles

AI synopsis

What people are saying

The overall sentiment is highly positive, with discussions emphasizing the novelty of using 'single-cell RNA sequencing' and 'reverse phenotyping' to profile T cells responding to SARS-CoV-2, often describing the study as 'important' and 'groundbreaking.' The tone conveys excitement about the potential applications in vaccine design and treatment, illustrating widespread recognition of the study’s significance.

AgreementStrong agreement

Most discussions strongly support the significance of the research, emphasizing its innovative methods and potential applications.

InterestHigh interest

Participants demonstrate high interest through detailed references to the technique of 'reverse phenotyping' and its relevance to COVID-19 T cell research.

EngagementModerate engagement

Engagement is moderate; some comments cite specific aspects like the profiling of T cells and implications for vaccine development, but few delve deeply into the methodology or results.

ImpactHigh impact

Many posts highlight the high potential impact, suggesting that this research could influence COVID-19 treatments and vaccine strategies, perceiving it as a breakthrough.

Abstract in brief

Researchers are exploring T cells that react to SARS-CoV-2 to better understand their characteristics and functions.
By using single-cell RNA sequencing and reverse phenotyping, the study identifies and profiles these T cells from COVID-19 patients without heavily relying on traditional methods.
The findings reveal differences in transcriptional signatures of activated T cells and their impact on T cells found in the respiratory tract of patients, highlighting the utility of reverse phenotyping in studying T cell responses across different conditions.

Read the full abstract

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MarkQuarter

@MarkQuarter · X

RT @Loose_Lab_Rat: Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping https:…

Sep 11, 2021 · 1 share · 1,612 followers View post →

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping https://t.co/okOJy9uM6a

Sep 3, 2021 · 1 share · 2,241 followers View post →

Interasma

@Interasma · X