PubHawk
Sci Transl Med July 2021 PMID 34321320

PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease.

Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A Swing, Sangwoo Ham, Sheila Pirooznia

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Mentions

47
Peak: 6 in Jul 2021
across 4 sources since Jul 2021

Extended reach

479,432
potential audience

Total likes

7,232

Video views

440,565

Mentions per month

Jul 2021 – Jul 2025

Where it's discussed

  • News33 articles
  • X / Twitter9 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions show a positive outlook towards the study, with posts like 'PARIS farnesylation prevents neurodegeneration' appearing multiple times, indicating recognition of its significance. Some contributions reference scientific concepts and potential clinical applications, highlighting a collective interest in the study's implications for future therapies.

AgreementModerate agreement

Most discussions express support or find the research promising, highlighting the protective role of farnesylation.

InterestModerate interest

The topics generate moderate curiosity, with several posts emphasizing the potential implications for Parkinson's treatment.

EngagementModerate engagement

Posts reference specific mechanisms like PARIS farnesylation and mention related genes, indicating thoughtful engagement.

ImpactModerate impact

The research is viewed as potentially transformative for understanding and treating Parkinson's disease, suggesting a meaningful impact.

Abstract in brief

  • The study shows that preventing the accumulation of the protein PARIS, which interferes with cell functions, can protect against Parkinson's disease (PD) by farnesol, a compound that promotes a chemical modification called farnesylation on PARIS.
  • Farnesol helps by adding a farnesyl group to PARIS, reducing its ability to suppress PGC1, a gene important for neuron survival, thereby preventing neuron loss and behavioral issues in PD models.
  • In Parkinson's patients, the natural farnesylation of PARIS is decreased, suggesting that boosting this process with treatments like farnesol could be a promising way to help prevent or treat PD.
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Top posts

Most liked on X and Bluesky
ShorterLab
@ShorterLab · X

PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/4Rs1aJgHqp

Jul 28, 2021 · 6 likes · 2 shares · 12,062 followers View post →
Robert West, PhD ✝️
@westr · X

PARIS farnesylation prevents #neurodegeneration in models of #Parkinson’s disease https://t.co/EU0ntIKau3 #Parkin #farnesol #farnesylation #PPARGC1A

Jul 28, 2021 · 3 likes · 19,324 followers View post →
ملكة التصميم
@design_myb · X

@AhmadQ_79 @Fekrtany https://t.co/5DViMycZvR

Sep 22, 2022 · 1 like · 1,664 followers View post →
George Vlasuk
@GVlasuk · X

Interesting-PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/GDx8qZWAq4

Jul 28, 2021 · 1 like · 1,423 followers View post →
Meow Memes
@meowmemes1 · X

@sameerproject plz help the poor old lady she suffers more than others in that age, give her a little olive oil or coconut oil it helps with parkinson also water, sent paypal donation specific for her, may allah help, protect her and bless u for humanity and great effort https://t.co/qONfW5KiUz

Jul 22, 2025 · 1 like · 257 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

RT @ShorterLab: PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/4Rs1aJgHqp

Jul 28, 2021 · 2 shares · 3,217 followers View post →

All mentions

Meow Memes
@meowmemes1 · X

@sameerproject plz help the poor old lady she suffers more than others in that age, give her a little olive oil or coconut oil it helps with parkinson also water, sent paypal donation specific for her, may allah help, protect her and bless u for humanity and great effort https://t.co/qONfW5KiUz

Jul 22, 2025 · 1 like · 257 followers View post →
أبو عبدالعزيز
@todayplus0 · X

هل الباركنسون ناتج عن ضعف في وظائف الكلى؟ العلاج؛ التنويع في الأكل وخاصة البروتينات التي تحمي الدماغ https://t.co/JpCgl4n5rI

Aug 30, 2024 · 43 followers View post →
ملكة التصميم
@design_myb · X

@AhmadQ_79 @Fekrtany https://t.co/5DViMycZvR

Sep 22, 2022 · 1 like · 1,664 followers View post →
The ReNeural Project
@ReNeural · X

RT @ShorterLab: PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/4Rs1aJgHqp

Jul 29, 2021 · 2 shares · 409 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease https://t.co/A82Wk3UFEP #parkinsons #neurology https://t.co/sUCEsle3Sh

Jul 29, 2021 · 457 followers View post →
George Vlasuk
@GVlasuk · X

Interesting-PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/GDx8qZWAq4

Jul 28, 2021 · 1 like · 1,423 followers View post →
Robert West, PhD ✝️
@westr · X

PARIS farnesylation prevents #neurodegeneration in models of #Parkinson’s disease https://t.co/EU0ntIKau3 #Parkin #farnesol #farnesylation #PPARGC1A

Jul 28, 2021 · 3 likes · 19,324 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

RT @ShorterLab: PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/4Rs1aJgHqp

Jul 28, 2021 · 2 shares · 3,217 followers View post →
ShorterLab
@ShorterLab · X

PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease https://t.co/4Rs1aJgHqp

Jul 28, 2021 · 6 likes · 2 shares · 12,062 followers View post →