J Am Heart Assoc August 2021 PMID 34350769

Krüppel-Like Factor 15/Interleukin 11 Axis-Mediated Adventitial Remodeling Depends on Extracellular Signal-Regulated Kinases 1 and 2 Activation in Angiotensin II-Induced Hypertension.

Yue-Tong Guo, Yuan-Yuan Lu, Xiao Lu, Shun He, Shi-Jin Li, Shuai Shao, Han-Dan Zhou, Rui-Qi Wang, Xiao-Dong Li, Ping-Jin Gao

Mentions

7
Peak: 4 in Aug 2021
across 3 sources since Aug 2021

Extended reach

35,974
potential audience

Total likes

9

Video views

48

Mentions per month

Aug 2021 – Oct 2023

Where it's discussed

  • X / Twitter4 posts
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall comments show strong endorsement of the study’s importance and scientific rigor, with phrases like 'very well conducted' and references to its potential as a 'target' for therapy. The tone is optimistic and assumes significance, especially with mentions of specific mechanisms like ERK downstream effects and the possibility of new treatment strategies.

AgreementStrong agreement

Most discussions endorse the significance of the study, calling it 'very well conducted' and emphasizing its relevance as a 'novel target' for hypertension-related vascular issues.

InterestHigh interest

The topic on IL11, ERK signaling, and vascular remodeling clearly captures high interest, with posts highlighting detailed mechanisms and referring directly to the research as 'worth a read.'

EngagementModerate engagement

While many express support and curiosity, only a few delve into specific pathways like ERK downstream signaling and the role of KLF15, indicating moderate engagement.

ImpactHigh impact

Posts imply that this research could influence future treatments for hypertension-related vascular damage by targeting IL11 and ERK1/2, underscoring high potential impact.

Abstract in brief

  • The study investigates how angiotensin II (Ang II) induces adventitial remodeling in hypertension, highlighting the roles of IL11 and ERK1/2 signaling pathways in this process.
  • It finds that IL11 promotes fibrosis and inflammation in blood vessel walls, with ERK1/2 activation regulating IL11 expression through the repression of Krüppel-like factor 15; blocking IL11 reduces fibrosis when Ang II is present.
  • Overall, the research suggests that targeting ERK1/2 activation and IL11 could be effective strategies to prevent or treat vascular damage caused by hypertension.

Top posts

Most liked on X and Bluesky
JAHA
@JAHA_AHA · X

Kruppel-like factor 15/Interleukin 11 axis: a novel target in hypertension-associated vascular remodeling. https://t.co/jodqtOh8Ub #AHAJournals https://t.co/bUJWLAoA0a

Aug 13, 2021 · 4 likes · 1 share · 31,377 followers View post →
Stuart Cook
@stuartacook1 · X

IL11 in end-organ damage in hypertension Very well conducted study Biphasic ERK downstream of IL11 - exactly as we see. Worth a read https://t.co/bLRMraWs7W

Aug 6, 2021 · 4 likes · 1,165 followers View post →
CardioAcademic
@CardioAcademic · X

RT @JAHA_AHA: Kruppel-like factor 15/Interleukin 11 axis: a novel target in hypertension-associated vascular remodeling. https://t.co/jodqt…

Aug 13, 2021 · 1 share · 3,227 followers View post →
Cardio-Targets
@CardioTargets · X

Krüppel-Like Factor 15/Interleukin 11 Axis-Mediated Adventitial Remodeling Depends on Extracellular Signal-Regulated Kinases 1 and 2 Activation in Angiotensin II-Induced Hypertension https://t.co/5j5wqH0Spv

Aug 5, 2021 · 153 followers View post →

All mentions

CardioAcademic
@CardioAcademic · X

RT @JAHA_AHA: Kruppel-like factor 15/Interleukin 11 axis: a novel target in hypertension-associated vascular remodeling. https://t.co/jodqt…

Aug 13, 2021 · 1 share · 3,227 followers View post →
JAHA
@JAHA_AHA · X

Kruppel-like factor 15/Interleukin 11 axis: a novel target in hypertension-associated vascular remodeling. https://t.co/jodqtOh8Ub #AHAJournals https://t.co/bUJWLAoA0a

Aug 13, 2021 · 4 likes · 1 share · 31,377 followers View post →
Stuart Cook
@stuartacook1 · X

IL11 in end-organ damage in hypertension Very well conducted study Biphasic ERK downstream of IL11 - exactly as we see. Worth a read https://t.co/bLRMraWs7W

Aug 6, 2021 · 4 likes · 1,165 followers View post →
Cardio-Targets
@CardioTargets · X

Krüppel-Like Factor 15/Interleukin 11 Axis-Mediated Adventitial Remodeling Depends on Extracellular Signal-Regulated Kinases 1 and 2 Activation in Angiotensin II-Induced Hypertension https://t.co/5j5wqH0Spv

Aug 5, 2021 · 153 followers View post →