Cancers (Basel) August 2021 PMID 34359801

Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol.

Bart Geboers, Florentine E F Timmer, Alette H Ruarus, Johanna E E Pouw, Evelien A C Schouten, Joyce Bakker, Robbert S Puijk, Sanne Nieuwenhuizen, Madelon Dijkstra, M Petrousjka van den Tol, Jan J J de Vries, Daniela E Oprea-Lager, C Willemien Menke-van der Houven van Oordt, Hans J van der Vliet, Johanna W Wilmink

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Mentions

6
Peak: 2 in Aug 2021
across 3 sources since Aug 2021

Extended reach

3,602
potential audience

Total likes

34

Video views

1,311

Mentions per month

Aug 2021 – May 2025

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Several discussions express strong optimism about the novel combination of electroporation and immunotherapy, using words like 'promising,' 'exciting,' and 'hopeful,' which reveal high interest and engagement. The mention of clinical safety and potential for improved outcomes shows that users perceive the study as impactful, although some still view it as preliminary evidence rather than a definitive breakthrough.

AgreementModerate agreement

Most discussions recognize the innovative combination of treatments and see potential benefits for metastatic pancreatic cancer, indicating general agreement with the study’s approach.

InterestHigh interest

The enthusiastic tone and specific mentions of therapy combinations suggest high curiosity and engagement with the research details.

EngagementHigh engagement

Postings include detailed analysis of methodology and implications, reflecting deep engagement with the topic.

ImpactModerate impact

Participants believe this research could significantly influence future treatments for pancreatic cancer, seeing it as a potentially transformative study.

Abstract in brief

  • The study explores a new treatment approach combining irreversible electroporation (IRE), a tumor ablation technique, with immunotherapy drugs (nivolumab and a TollLike Receptor ligand) to stimulate the immune system against metastatic pancreatic cancer, which currently has limited treatment options.
  • The main goal is to assess the safety of this combined treatment in patients who have already received chemotherapy, by comparing three groups: nivolumab alone, IRE plus nivolumab, and IRE plus a TLR ligand followed by nivolumab.
  • The study involves detailed imaging, biopsies, blood tests, and quality of life assessments to evaluate how well the treatment works and if it can provoke a strong, lasting immune response to improve patient outcomes in pancreatic cancer.

Top posts

Most liked on X and Bluesky
Tom
@petctimaging · X

Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol https://t.co/VM7F2S8rho

Aug 9, 2021 · 2,176 followers View post →
Immuno-Oncology
@immuno_onc · X

Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol https://t.co/R3Dz4AoJmV https://t.co/1xtPipWwEr

Aug 7, 2021 · 115 followers View post →

All mentions

Tom
@petctimaging · X

Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol https://t.co/VM7F2S8rho

Aug 9, 2021 · 2,176 followers View post →
Immuno-Oncology
@immuno_onc · X

Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol https://t.co/R3Dz4AoJmV https://t.co/1xtPipWwEr

Aug 7, 2021 · 115 followers View post →