J Am Heart Assoc August 2021 PMID 34365799

Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV.

Nalini A Colaco, Teresa S Wang, Yifei Ma, Rebecca Scherzer, Olga R Ilkayeva, Patrice Desvigne-Nickens, Eugene Braunwald, Adrian F Hernandez, Javed Butler, Svati H Shah, Sanjiv J Shah, Priscilla Y Hsue

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Mentions

Peak: 7 in Aug 2021

across 3 sources since Aug 2021

Extended reach

37,247

potential audience

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Mentions per month

Aug 2021 – Sep 2023

Where it's discussed

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Facebook3 posts
YouTube1 videos

AI synopsis

What people are saying

Many discussions highlight the relevance of TMAO as a marker for heart damage in HIV patients, using phrases like 'potential link' and 'possible target for monitoring.' The tone reflects a combination of curiosity and cautious optimism, emphasizing the study's importance and potential clinical impact while also recognizing that further research is needed.

AgreementModerate agreement

Most discussions acknowledge the study’s findings, emphasizing the potential link between TMAO and cardiac fibrosis in people with HIV.

InterestHigh interest

Participants show high curiosity about the implications for HIV-related cardiovascular disease, indicating strong interest.

EngagementModerate engagement

Comments include references to the study’s methodology and potential clinical impacts, demonstrating a moderate level of engagement.

ImpactModerate impact

The discussions suggest the findings could influence future research or treatment approaches, though they are still preliminary.

Abstract in brief

People living with HIV have a higher risk of heart problems like diastolic dysfunction, heart failure, and sudden cardiac death, which are linked to increased myocardial fibrosis, and the study investigates the role of the gut metabolite TMAO in this process.
The research found that higher levels of TMAO are associated with increased myocardial fibrosis and indicators of diastolic dysfunction in people with HIV, suggesting TMAO could serve as a marker for early heart tissue changes.
Overall, the study suggests that TMAO, a compound derived from gut bacteria, may contribute to heart tissue damage in people with HIV, highlighting its potential as a target for monitoring or preventing cardiac fibrosis.

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All mentions

Role of Transmethylamine N-Oxide in Cardiac Fibrosis in People with HIV

Higher levels of TMAO are associated with increased myocardial fibrosis and diastolic dysfunction in people living with HIV, suggesting TMAO may serve as a biomarker for early cardiac tissue changes and potential target…

Social RTCL TV · Sep 28, 2023 33 views

Teresa Wang

@teresa_wang88 · X

RT @JAHA_AHA: Gut metabolite TMAO associated with diffuse myocardial fibrosis in HIV+ individuals...potential link for HIV-related CVD? htt…

Aug 18, 2021 · 5 shares · 254 followers View post →

JAHA

@JAHA_AHA · X

Aug 18, 2021 · 8 likes · 5 shares · 31,381 followers View post →

Scott Cameron

@2Scottish · X

Transmethylamine‐N‐Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV | Journal of the American Heart Association https://t.co/TywAIBGnYy

Aug 9, 2021 · 2,116 followers View post →

MasMaz

@MasMazCom · X

Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV - https://t.co/9dNl0mKMHZ

Aug 9, 2021 · 169 followers View post →

Dataemia

@Dataemia · X

Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV - https://t.co/s2lKoblgY3

Aug 9, 2021 · 967 followers View post →

CMR Papers

@CMRPapers · X

Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV https://t.co/kLSzB6cCmS

Aug 9, 2021 · 1 like · 1,198 followers View post →

Symbiosis papers

@Symbiosispapers · X

Transmethylamine-N-Oxide Is Associated With Diffuse Cardiac Fibrosis in People Living With HIV https://t.co/phlXgq92Q9

Aug 9, 2021 · 1,109 followers View post →