J Am Heart Assoc August 2021 PMID 34369166

Colchicine in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Trials.

Thomas Kofler, Reto Kurmann, Dirk Lehnick, Giacomo Maria Cioffi, Sujay Chandran, Adrian Attinger-Toller, Stefan Toggweiler, Richard Kobza, Federico Moccetti, Florim Cuculi, Sanjit S Jolly, Matthias Bossard

Full text PDF Download social card

Mentions

Peak: 23 in Aug 2021

across 4 sources since Jun 2020

Extended reach

161,317

potential audience

Total likes

Video views

245

Mentions per month

Jun 2020 – Sep 2025

Where it's discussed

X / Twitter28 posts
Facebook2 posts
Bluesky1 posts
YouTube1 videos

AI synopsis

What people are saying

Overall, the discussions reveal a cautious optimism about colchicine’s role in managing coronary artery disease, with posts citing the significant reduction in ischemic events and side effects, as well as noting its potential as an auxiliary treatment. The language, including terms like 'promising' and 'interesting', demonstrates both curiosity and recognition of the research's importance, yet reflects an awareness of its limitations in affecting mortality and side effects.

AgreementModerate agreement

Most discussions seem to acknowledge the findings, especially the benefits of colchicine in reducing myocardial infarction and stroke risks, indicating general support or acceptance of the results.

InterestHigh interest

The posts exhibit high curiosity, with many emphasizing the potential of colchicine as a promising treatment, as shown by phrases like 'interesting', 'promising', and calls for further discussion about its clinical use.

EngagementModerate engagement

Many discussions reference specific data points and clinical implications, such as odds ratios and side effects, reflecting a moderate level of detailed engagement.

ImpactModerate impact

While some posts highlight the potential shift in treatment strategies, the mention that colchicine doesn't affect mortality and its side effects suggests the perceived real-world impact might be moderate, not transformative.

Abstract in brief

This systematic review and meta-analysis examined whether colchicine, an anti-inflammatory drug, is effective and safe for patients with coronary artery disease (CAD), finding that it significantly reduces the risk of myocardial infarction and stroke but does not impact overall or cardiovascular mortality.
The analysis included 13 randomized trials with over 13,000 patients, showing that colchicine lowers the odds of heart attacks (OR 0.64) and strokes (OR 0.50), but increases the likelihood of gastrointestinal side effects, and no clear evidence suggests it affects mortality rates.
Based on trial sequential analyses, the strongest evidence supports colchicine's benefit in reducing myocardial infarction risk, though further research is needed for its long-term safety and effects on mortality.

Read the full abstract

All mentions

Efficacy and Safety of Colchicine in Coronary Artery Disease Patients

This systematic review and meta-analysis evaluated colchicine's effectiveness and safety for coronary artery disease, showing it reduces myocardial infarction and stroke risk but may increase gastrointestinal side…

Social RTCL TV · Sep 19, 2023 245 views

Nixa Sedes, MD

@nixassedes.bsky.social · Bluesky

Efficacy and safety of colchicine in patients with coronary artery disease: An updated meta-analysis of randomized controlled trials

Sep 14, 2025 View post →

Leonardo Soto Muñoz

@LeonardoSotoMu · X

En pacientes con enfermedad arterial coronaria establecida, la colchicina permitie reducir el riesgo de IM y ACV, con una tasa mayor dereacciones adversas GI. NO inherencia sobre mortalidad. https://t.co/KyBEbsoK8u

Dec 7, 2021 · 8,533 followers View post →

Leonardo Soto Muñoz

@LeonardoSotoMu · X

@SABOURETCardio https://t.co/KyBEbsoK8u

Dec 5, 2021 · 2 likes · 8,533 followers View post →

McMaster University Department of Medicine

@MacDeptMed · X

RECENT PUBLICATION: Colchicine in Patients With #CoronaryArteryDisease: A Systematic Review and Meta‐Analysis of Randomized Trials. Our own @SanjitSJolly among authors. https://t.co/LoDU90wEyL @McMasterU @HHS_staff #MedEd #BrighterWorld https://t.co/DtX69uqYoL

Oct 21, 2021 · 2 likes · 4,147 followers View post →

Florin-Dan

@florindanpopesq · X

➡️Efficacy and safety of #colchicine in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials [Bytyçi I et al. Br J Clin Pharmacol. 2021] https://t.co/Ib0bMzyQB3

Aug 25, 2021 · 4,078 followers View post →

fausto heredia z.

@drfherediaz · X

RT @doctorheart00: Colchicine en Pericarditis, Enf Coronaria ek inflamación vascular. Produce además Enf U/P. https://t.co/oDjwLoDRy0

Aug 20, 2021 · 2 shares · 4,360 followers View post →

Fernando Aguirre P

@doctorheart00 · X

Colchicine en Pericarditis, Enf Coronaria ek inflamación vascular. Produce además Enf U/P. https://t.co/oDjwLoDRy0

Aug 20, 2021 · 2 likes · 2 shares · 2,324 followers View post →