Hypertension September 2021 PMID 34379435

Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument.

Ricky D Turgeon, Andrew D Althouse, Jordana B Cohen, Bogdan Enache, John B Hogenesch, Michael E Johansen, Raj Mehta, Gideon Meyerowitz-Katz, Boback Ziaeian, Swapnil Hiremath

Mentions

27
Peak: 6 in Jun 2025
across 4 sources since Aug 2021

Extended reach

117,767
potential audience

Total likes

77

Video views

1,356

Mentions per month

Aug 2021 – Dec 2025

Where it's discussed

  • X / Twitter14 posts
  • News9 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall analysis captures a nuanced debate, with some posts expressing skepticism about the phenomenon's validity, such as the comparison to past controversies over chronotherapy, while others praise critical reviews and detailed analyses like the paper on Hygia. The tone varies between cautious skepticism and scholarly engagement, reflecting a community actively dissecting the evidence and implications of the publication.

AgreementNeither agree nor disagree

The discussions reflect a mixed stance, with some posts acknowledging the controversy and others questioning the validity of the concept, leading to a neutral overall agreement level.

InterestHigh interest

Posts show high engagement and curiosity, especially with references to detailed critical papers and ongoing debates.

EngagementModerate engagement

Many discussions demonstrate a thoughtful engagement, citing specific studies like Hygia and referencing critical appraisals, indicating deeper involvement.

ImpactModerate impact

The conversations highlight ongoing scientific debates which could influence future research and clinical practices, suggesting moderate impact.

Abstract in brief

  • The article discusses concerns that taking blood pressure medications at bedtime may cause excessively low nighttime blood pressure, potentially leading to dizziness or falls.
  • Critics argue that the evidence supporting bedtime dosing as a safer or more effective approach is limited or inconsistent, raising questions about its widespread recommendation.
  • There is also debate over whether lowering nighttime blood pressure could have unintended negative effects, such as impaired organ perfusion or increased risk of adverse events.

Top posts

Most liked on X and Bluesky
owl
@owl_posting · X

+1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medication and now it isn’t: https://t.co/Pi4spZps4k

Jun 7, 2025 · 21 likes · 4 shares · 11,870 followers View post →
John Mandrola, MD
@drjohnm · X

Even better than this thread is this detailed critical appraisal paper from numerous Twitter luminaries on Hygia. Great work to all the authors of this paper. Gosh it's good. https://t.co/Cx1wYxICpS #ESCCongress https://t.co/agytHWqx1t

Aug 26, 2022 · 15 likes · 1 share · 68,657 followers View post →
Pitt General Internal Medicine
@PittGIM · X

A

Jan 14, 2022 · 7 likes · 5 shares · 4,648 followers View post →
Society for Research on Biological Rhythms
@SRBR_Outreach · X

Does bedtime dosing of antihypertensive medications help lower nighttime blood pressure? The two sides of the argument -- Pros (https://t.co/34tjAnoqVW) & Cons (https://t.co/B4KV7ccI1t) @AHAScience @jbhclock #circadian #rhythm #chronomedicine #chronotherapy

Aug 12, 2021 · 5 likes · 2 shares · 5,458 followers View post →
Ricky Turgeon PharmD
@Ricky_Turgeon · X

@drjohnm Thanks John; better yet read the subsequent con paper https://t.co/8QdwaLMymi that painstakingly outlines every issue & reporting omission of HYGIA. Notably, Hermida didn't use this as an opportunity to address these oft-raised concerns, just threw shade at the other trials

Aug 26, 2022 · 5 likes · 1,592 followers View post →
owl
@owl_posting · X

@carole_lunny @yourmedmonitor think its about this: https://t.co/Pi4spZps4k interesting take!

Jun 7, 2025 · 11,870 followers View post →

All mentions

Charu mahajan
@Charumahajan10 · X

RT @owl_posting: +1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medica…

Jun 10, 2025 · 4 shares · 4 followers View post →
Alex Murphy
@techexploreram · X

RT @owl_posting: +1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medica…

Jun 9, 2025 · 4 shares · 21 followers View post →
Cristina Pérez
@neuronsngreen · X

RT @owl_posting: +1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medica…

Jun 9, 2025 · 4 shares · 20 followers View post →
Jamie Timmons
@metapredict · X

RT @owl_posting: +1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medica…

Jun 9, 2025 · 4 shares · 2,059 followers View post →
owl
@owl_posting · X

+1 to this perhaps not being a real phenomenon: chronotherapy was also once suspected to be useful for hypertensive medication and now it isn’t: https://t.co/Pi4spZps4k

Jun 7, 2025 · 21 likes · 4 shares · 11,870 followers View post →
owl
@owl_posting · X

@carole_lunny @yourmedmonitor think its about this: https://t.co/Pi4spZps4k interesting take!

Jun 7, 2025 · 11,870 followers View post →
Bogdan Enache
@bogdienache · X

RT @drjohnm: Even better than this thread is this detailed critical appraisal paper from numerous Twitter luminaries on Hygia. Great work…

Aug 26, 2022 · 1 share · 2,782 followers View post →
Ricky Turgeon PharmD
@Ricky_Turgeon · X

@drjohnm Thanks John; better yet read the subsequent con paper https://t.co/8QdwaLMymi that painstakingly outlines every issue & reporting omission of HYGIA. Notably, Hermida didn't use this as an opportunity to address these oft-raised concerns, just threw shade at the other trials

Aug 26, 2022 · 5 likes · 1,592 followers View post →
John Mandrola, MD
@drjohnm · X

Even better than this thread is this detailed critical appraisal paper from numerous Twitter luminaries on Hygia. Great work to all the authors of this paper. Gosh it's good. https://t.co/Cx1wYxICpS #ESCCongress https://t.co/agytHWqx1t

Aug 26, 2022 · 15 likes · 1 share · 68,657 followers View post →
Ricky Turgeon PharmD
@Ricky_Turgeon · X

RT @PittGIM: A

Jan 14, 2022 · 5 shares · 1,592 followers View post →
DrJMLuther
@DrJMLuther · X

RT @PittGIM: A

Jan 14, 2022 · 5 shares · 2,629 followers View post →
Pitt General Internal Medicine
@PittGIM · X

A

Jan 14, 2022 · 7 likes · 5 shares · 4,648 followers View post →
Jonathan Cedernaes
@JCedernaes · X

RT @SRBR_Outreach: Does bedtime dosing of antihypertensive medications help lower nighttime blood pressure? The two sides of the argument -…

Aug 12, 2021 · 2 shares · 3,127 followers View post →
Society for Research on Biological Rhythms
@SRBR_Outreach · X

Does bedtime dosing of antihypertensive medications help lower nighttime blood pressure? The two sides of the argument -- Pros (https://t.co/34tjAnoqVW) & Cons (https://t.co/B4KV7ccI1t) @AHAScience @jbhclock #circadian #rhythm #chronomedicine #chronotherapy

Aug 12, 2021 · 5 likes · 2 shares · 5,458 followers View post →