The overall sentiment reflects positive engagement, with many posts emphasizing the importance of titin as a key sensor for muscle adaptation, using words like 'interesting' and 'crucial'. The tone is curious and appreciative of potential advancements, indicating meaningful interest and perceived impact in the field.
AgreementModerate agreement
Most discussions agree that the paper highlights the significant role of titin in muscle growth, with some emphasizing its potential to change understanding of muscle physiology.
InterestHigh interest
Users show high interest in the topic, often referencing the importance of mechanosensing and muscle proteins in their fitness routines and scientific curiosity.
EngagementModerate engagement
There is a moderate level of deep engagement, with comments discussing the implications of the model and references to related studies, but few detailed critiques.
ImpactModerate impact
The discussions suggest that the publication could influence future research and practical approaches in exercise science and muscle training.
Abstract in brief
The study explains how muscles sense different types of load through a structure called titin, specifically its kinase domain (TK), which acts as a mechanical switch that reacts more strongly to high-load resistance exercises than to endurance activities.
A mathematical model was built to describe how TK conformational changes lead to signaling that promotes muscle growth (hypertrophy) or shrinkage (atrophy), factoring in the kinetics of phosphate and protein synthesis in muscle fibers.
The model predicts that muscle size and tension reach a balance (homeostasis) but can respond effectively to training or disuse, with higher loads stimulating growth and reduced tension leading to muscle loss, aligning well with experimental observations.
Aug 14, 2021 · 156 likes · 34 shares · 3,945 followersView post →
AP
Andy Galpin, PhD
@DrAndyGalpin · X
We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role of Titin (my favorite muscle-related protein) as a major sensor & regulating mechanism.
Just a "model," for now, but plausible.
https://t.co/Qbhoy571y6
Aug 17, 2021 · 80 likes · 12 shares · 95,304 followersView post →
Aug 16, 2021 · 16 likes · 4 shares · 3,754 followersView post →
BJ
Biophysical Journal
@BiophysJ · X
#OPENACCESS: "Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load" by Neil Ibata and Eugene M. Terentjev. https://t.co/mzrtgG24a4 @Cambridge_Uni @DeptofPhysics
Most questions from the ATG Science community focus on knees and shoulders. In this video, I outline the biological mechanisms of common ATG exercises and their application to improving pain-free movement. Learn how…
This video explains how muscles sense different loads via the titin structure, acting as a mechanical switch to promote growth or atrophy. It covers a mathematical model predicting muscle response to various training…
@burned_pixl Он очень грубо сказал, но он прав.
https://t.co/vyn4vxBSIN
https://t.co/hdw0ww7F2L
https://t.co/3iGAFsl17x
В последнем исследовании говорится, что не обязательно брать большие веса, можно достичь гипертрофии путем повышения повторений, но с учетом умеренного веса, а не детского
Why exercise builds muscles: Titin mechanosensing controls skeletal muscle growth under load Neil Ibata, Eugene M. Terentjev | Biophysical Journal
https://t.co/LNhNUOrHc1
https://t.co/K9THp7WWvm
Because of a Mechanosensor in muscle — Titin
Oct 23, 2024 · 1 like · 3,415 followersView post →
#OPENACCESS: "Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load" by Neil Ibata and Eugene M. Terentjev. https://t.co/mzrtgG24a4 @Cambridge_Uni @DeptofPhysics
Conque estas son las famosas micro rupturas de las fibras musculares de las que la tradición verbal habla...
Neil Ibata et al, Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load, Biophysical Journal (2021). DOI: 10.1016/j.bpj.2021.07.023
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 4,538 followersView post →
D
dpfaff
@PfaffSC · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 14,322 followersView post →
H
Hec
@Muscles_n_Mitos · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 63 followersView post →
LW
Lorenzo S.Wayne
@LorenzoSWayne · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 51 followersView post →
SD
Spyridon Methenitis, Ph.D.
@s_metheni · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 187 followersView post →
MA
Matevz Arcon
@Mat_Arcon · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 18, 2021 · 12 shares · 151 followersView post →
N
NaO
@spikeoutOXY · X
RT @DrAndyGalpin: We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role o…
Aug 17, 2021 · 12 shares · 155 followersView post →
AP
Andy Galpin, PhD
@DrAndyGalpin · X
We've still got much to learn about the "load-induced" muscle hypertrophy process.
This new paper argues for the role of Titin (my favorite muscle-related protein) as a major sensor & regulating mechanism.
Just a "model," for now, but plausible.
https://t.co/Qbhoy571y6
Aug 17, 2021 · 80 likes · 12 shares · 95,304 followersView post →
Aug 15, 2021 · 2 shares · 1,362 followersView post →
AG
Amelia Guadalupe Grau
@AmeliaG_Grau · X
Very interesting point of view on “Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load” https://t.co/jjq7d7RMHn
Aug 15, 2021 · 4 likes · 2 shares · 767 followersView post →
L
LibKey
@libkey_io · X
@nick_krontiris Help your colleagues avoid a paywall by accessing the article from their libraries: https://t.co/kVki2Ls0lK
Simply add https://t.co/SXSePSX5De to the DOI URL when sharing articles on Twitter and everywhere else!
#arXiv Why exercise builds muscles: Titin mechanosensing controls skeletal muscle growth under load https://t.co/3xOIfrvL5s a model with a steady-state solution (homeostasis) for muscle cross-sectional area and tension; a quantitatively plausible hypertrophic response to training https://t.co/Bi8RQN0UTW
Feb 6, 2021 · 6 likes · 2 shares · 45,108 followersView post →
LW
Lorenzo S.Wayne
@LorenzoSWayne · X
@Nlbata
Why exercise builds muscles: Titin mechanosensing controls skeletal muscle growth under load
Neil Ibata, Eugene M. Terentjev
https://t.co/LV4LRkAyDB
Dosis og form: 3–5 g kreatin monohydrat hver dag. Loading er ligegyldigt. Timing er mindre vigtigt, men sørg for at tage det hver dag. Tag det når det passer ...
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