Psychoneuroendocrinology November 2021 PMID 34416504

High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: A preliminary report.

Georg S Kranz, Marie Spies, Chrysoula Vraka, Ulrike Kaufmann, Eva-Maria Klebermass, Patricia A Handschuh, Marius Ozenil, Matej Murgaš, Verena Pichler, Lucas Rischka, Lukas Nics, Melisande E Konadu, Harald Ibeschitz, Tatjana Traub-Weidinger, Wolfgang Wadsak

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Mentions

Peak: 2 in Dec 2021

across 4 sources since Dec 2021

Extended reach

20,039

potential audience

Total likes

509

Video views

18,452

Mentions per month

Dec 2021 – Sep 2025

Where it's discussed

X / Twitter2 posts
YouTube2 videos
Facebook2 posts
News2 articles

AI synopsis

What people are saying

Overall, the discussions reflect curiosity about how testosterone affects brain chemistry, with posts noting the significance of reduced MAOA levels in transgender men and considering potential mental health implications. Words such as 'interesting,' 'potentially transformative,' and 'important' highlight the positive tone and scientific curiosity, indicating moderate engagement with the research’s broader impact.

AgreementModerate agreement

Most discussions recognize the study's findings as meaningful, with some emphasizing the potential implications for mental health and hormonal therapy.

InterestHigh interest

Readers show high curiosity, often referencing the biological mechanisms and possible real-world applications.

EngagementModerate engagement

Participants demonstrate moderate engagement by mentioning specific details and expressing opinions about the research methodology and significance.

ImpactModerate impact

The conversations suggest that the study could influence future research or clinical practices, indicating a moderate level of impact.

Abstract in brief

The study examines how gender hormone treatments affect brain chemistry, specifically looking at monoamine oxidase A (MAOA), which is important for serotonin regulation and is linked to depression.
In transgender men undergoing testosterone treatment, researchers found a significant reduction in MAOA levels in several brain regions, suggesting testosterone might influence mood-related neurotransmission.
No significant MAOA changes were observed in transgender women receiving estrogen, indicating different hormonal effects on brain chemistry that could impact depression and treatment responses.]

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All mentions

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ComprehensivePNEC

@CPNECJournal · X

RT @PNECJournal: High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: A preliminary report https://t.co…

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Psychoneuroendocrinology

@PNECJournal · X

High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: A preliminary report https://t.co/awTvBfl6Sm https://t.co/XsnZlFPGLR

Dec 24, 2021 · 6 likes · 1 share · 1,339 followers View post →