Neurol Int August 2021 PMID 34449705

Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review.

Amber N Edinoff, Haseeb A Akuly, Tony A Hanna, Carolina O Ochoa, Shelby J Patti, Yahya A Ghaffar, Alan D Kaye, Omar Viswanath, Ivan Urits, Andrea G Boyer, Elyse M Cornett, Adam M Kaye

Mentions

58
Peak: 25 in Sep 2022
across 3 sources since Sep 2021

Extended reach

126,321
potential audience

Total likes

67

Video views

62

Mentions per month

Sep 2021 – Aug 2025

Where it's discussed

  • X / Twitter35 posts
  • News21 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several comments delve into specific adverse effects discussed in the review, such as hyponatremia, QT prolongation, and serotonin syndrome, emphasizing the importance of monitoring and individual risk assessments. The tone varies from informational to cautious, with words like 'risk,' 'should,' and 'recommend' underscoring concern and clinical relevance, which supports a moderate impact perception.

AgreementModerate agreement

Most discussions acknowledge the potential adverse effects of SSRIs highlighted in the review, indicating general support or acceptance of the findings, such as references to specific risks like hyponatremia, serotonin syndrome, and cardiac concerns.

InterestHigh interest

Posts demonstrate significant curiosity, with multiple mentions of detailed adverse effects and calls for further research, showing that readers find the topic relevant and worthy of investigation.

EngagementModerate engagement

The discussions include references to clinical implications, such as recommending regular eye exams, discussing risk factors, and emphasizing the need for individual risk-benefit analysis, suggesting some depth of engagement with the content.

ImpactModerate impact

While the posts reflect concern about adverse effects and suggest clinical considerations, the overall tone indicates awareness rather than a sense that the publication might dramatically change practice or policy. The perceived impact is moderate.

Top posts

Most liked on X and Bluesky
IntegralAnswers
@IntegralAnswers · X

3. MDPI Review – Adolescents’ Risk Details FDA black-box warning for increased suicidality in youth and notes common side effects (GI upset, sexual dysfunction). https://t.co/E4SNZDLU4m

Jul 22, 2025 · 20 likes · 2 shares · 7,860 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers should recommend regular eye examinations for patients on SSRIs." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 15 likes · 4 shares · 6,494 followers View post →
Roe
@GraceRoe5142 · X

@playingomori @ChaosRocket So it is rare in adults. Normally a very small percent of patients who already had ideation. And even then it’s often hard to parse if that’s a side effect of the SSRI, or just the worsening of a disorder in ppl for whom SSRIs don’t work. https://t.co/cL3o1UddB2

Mar 15, 2025 · 11 likes · 775 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Serotonin syndrome is a potentially fatal consequence of serotonergic overactivity....increasing due to widespread SSRI use...majority of cases involve a combination of serotonergic drugs, though...monotherapy may also lead to serotonin syndrome." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 5 likes · 2 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Among all #antidepressants, SSRIs carry the highest risk of hyponatremia, especially in the initial weeks of treatment....risk factors include concomitant use of hyponatremia-inducing drugs, low body weight, female...low serum sodium, & severe illness" https://t.co/HpoNKCG3G6

Sep 21, 2022 · 2 likes · 2 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Given the widespread use of SSRIs & their ability to cross the placental barrier, numerous studies have evaluated the association between SSRIs & congenital defects, with inconsistent findings....decisions [for] pregnant women should be individualized..." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 2 likes · 6,494 followers View post →

All mentions

Emma Rose
@EmmaRos4203433 · X

@P_McCulloughMD @SecKennedy @NathanMeadPhD @CPriceRogers Indeed ♥️

Aug 29, 2025 · 1,262 followers View post →
Maegan Laporte unacceptable independent
@maegan_laporte · X

RT @IntegralAnswers: 3. MDPI Review – Adolescents’ Risk Details FDA black-box warning for increased suicidality in youth and notes common s…

Jul 22, 2025 · 2 shares · 5,655 followers View post →
Nels Olsen
@yegnho · X

RT @IntegralAnswers: 3. MDPI Review – Adolescents’ Risk Details FDA black-box warning for increased suicidality in youth and notes common s…

Jul 22, 2025 · 2 shares · 602 followers View post →
IntegralAnswers
@IntegralAnswers · X

3. MDPI Review – Adolescents’ Risk Details FDA black-box warning for increased suicidality in youth and notes common side effects (GI upset, sexual dysfunction). https://t.co/E4SNZDLU4m

Jul 22, 2025 · 20 likes · 2 shares · 7,860 followers View post →
Roe
@GraceRoe5142 · X

@playingomori @ChaosRocket So it is rare in adults. Normally a very small percent of patients who already had ideation. And even then it’s often hard to parse if that’s a side effect of the SSRI, or just the worsening of a disorder in ppl for whom SSRIs don’t work. https://t.co/cL3o1UddB2

Mar 15, 2025 · 11 likes · 775 followers View post →
Frank Rizzo
@RealFrankRizz · X

@Truth2Everyone @4Mischief I think it’s lack of family structure coupled with medicated kids and compounded by indoctrination. Kids from a good home (nuclear family) are not the issue. SSRI are shown to alter growing kids brains (https://t.co/GGgIeIVekv). And lastly the indoctrinating in schools allows the

Sep 4, 2024 · 486 followers View post →
x800.btc
@psifin · X

@thaumaturghos @optimisster 2003 год и 14 дней приема? Серьезно?)) Вот тут можно ознакомиться со списком физиологических побочек: https://t.co/riBhovGpC3 Еще пишут про когнитивные последствия длительного приема (несколько месяцев - год), особенно, у молодых и здоровых. Видел обзор, но потерял, а заново

Jul 28, 2024 · 564 followers View post →
Medical Cover Up
@medicalcoverup · X

Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review https://t.co/nq1HwtoOgf https://t.co/EHwVDmPs4w

Jun 14, 2023 · 1,300 followers View post →
DBranconier
@DarleneBrancon1 · X

@kennymac782641 @MrsNormanToYou @bennyjohnson Yep. And, suicide by cop is still suicide & applies to each mass shooting

Mar 30, 2023 · 119 followers View post →
recovery&renewal
@recover2renew · X

RT @recover2renew: #SSRIs and #ADRs #AdverseEffects ... "The aim of this review is to #educate #clinicians on potential #adverseeffects of…

Sep 30, 2022 · 2 shares · 4,133 followers View post →
Alyne Duthie
@DuthieAlyne · X

RT @recover2renew: #SSRIs and #ADRs #AdverseEffects ... "The aim of this review is to #educate #clinicians on potential #adverseeffects of…

Sep 30, 2022 · 2 shares · 1,892 followers View post →
recovery&renewal
@recover2renew · X

#SSRIs and #ADRs #AdverseEffects ... "The aim of this review is to #educate #clinicians on potential #adverseeffects of SSRIs." Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review https://t.co/tfN1LPhHfy #mdpineurolint via @MDPIOpenAccess

Sep 30, 2022 · 1 like · 2 shares · 4,133 followers View post →
Saeed Doroudiani, MSc/PhD, PEng
@SaeedDoroudiani · X

RT @Altostrata: "Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers s…

Sep 22, 2022 · 4 shares · 926 followers View post →
La Double Vie
@Onbodyandsoul · X

RT @Altostrata: "Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers s…

Sep 22, 2022 · 4 shares · 1,084 followers View post →
Jean Hardwick
@JeanHardwick8 · X

RT @Altostrata: "Among all #antidepressants, SSRIs carry the highest risk of hyponatremia, especially in the initial weeks of treatment....…

Sep 22, 2022 · 2 shares · 202 followers View post →
Susan
@BlackshepSusan · X

RT @Altostrata: "Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers s…

Sep 22, 2022 · 4 shares · 4,126 followers View post →
io
@kilnerevonnet · X

RT @Altostrata: "Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers s…

Sep 22, 2022 · 4 shares · 706 followers View post →
recovery&renewal
@recover2renew · X

RT @Altostrata: "...EPS in patients treated with SSRIs has been observed in numerous studies. One study identified 86 case reports connecti…

Sep 22, 2022 · 2 shares · 4,133 followers View post →
recovery&renewal
@recover2renew · X

RT @Altostrata: "Treatment Emergent Suicidal Ideation (TESI) is the increased likelihood of developing SI after beginning treatment with an…

Sep 22, 2022 · 1 share · 4,133 followers View post →
recovery&renewal
@recover2renew · X

RT @Altostrata: "With regards to adverse effects, many are shared among all SSRIs to varying degrees, including sexual dysfunction, gastroi…

Sep 22, 2022 · 2 shares · 4,133 followers View post →
Lauren C.
@Lau_Cob_ · X

RT @Altostrata: "Serotonin syndrome is a potentially fatal consequence of serotonergic overactivity....increasing due to widespread SSRI us…

Sep 22, 2022 · 2 shares · 2,561 followers View post →
Anna King
@AnnaKin06551830 · X

RT @Altostrata: "Serotonin syndrome is a potentially fatal consequence of serotonergic overactivity....increasing due to widespread SSRI us…

Sep 22, 2022 · 2 shares · 3,089 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"While SSRIs are much better tolerated than their predecessors, the TCAs & MAOIs, there are potential adverse effects....common ones include GI upset, insomnia, agitation, & sexual dysfunction....Ultimately, [for] any patient...a risk–benefit analysis...." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 1 like · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"With regards to adverse effects, many are shared among all SSRIs to varying degrees, including sexual dysfunction, gastrointestinal distress, prolonged QT interval, & xerostomia." Selective Serotonin Reuptake Inhibitors & Adverse Effects... https://t.co/HpoNKCG3G6

Sep 21, 2022 · 2 likes · 2 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"In adults, specific symptoms, such as insomnia, activation, & anxiety during antidepressant treatment, may increase [suicidal ideation]....Clinical trials that control for these variables, are needed to further determine the direct effect of SSRIs on SI." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Treatment Emergent Suicidal Ideation (TESI) is the increased likelihood of developing SI after beginning treatment with an SSRI or other #antidepressant....subjectivity in defining SI has contributed to [studies'] inconclusivity in adults." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 1 share · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Recent studies suggest a positive association between long-term use of SSRIs & the development of cataracts....providers should recommend regular eye examinations for patients on SSRIs." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 15 likes · 4 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Among all #antidepressants, SSRIs carry the highest risk of hyponatremia, especially in the initial weeks of treatment....risk factors include concomitant use of hyponatremia-inducing drugs, low body weight, female...low serum sodium, & severe illness" https://t.co/HpoNKCG3G6

Sep 21, 2022 · 2 likes · 2 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Given the widespread use of SSRIs & their ability to cross the placental barrier, numerous studies have evaluated the association between SSRIs & congenital defects, with inconsistent findings....decisions [for] pregnant women should be individualized..." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 2 likes · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"SSRIs have been associated with photosensitivity, spontaneous bruising, pruritus, alopecia, & urticaria....Rarely, serious cutaneous reactions such as Stevens–Johnson syndrome, toxic epidermal necrosis....& drug-induced hypersensitivity reactions...." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 1 like · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"SSRIs, especially citalopram, can prolong the QT interval...which may trigger fatal reentrant tachycardias, such as Torsades de Pointes....compare the risk of QT prolongation versus the clinic risk of lowering citalopram/escitalopram dose...." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 1 like · 6,494 followers View post →
dystobot (broken)
@dystobot_broken · X

RT @Altostrata: "...EPS in patients treated with SSRIs has been observed in numerous studies. One study identified 86 case reports connecti…

Sep 21, 2022 · 2 shares · 686 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"Serotonin syndrome is a potentially fatal consequence of serotonergic overactivity....increasing due to widespread SSRI use...majority of cases involve a combination of serotonergic drugs, though...monotherapy may also lead to serotonin syndrome." https://t.co/HpoNKCG3G6

Sep 21, 2022 · 5 likes · 2 shares · 6,494 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

"...EPS in patients treated with SSRIs has been observed in numerous studies. One study identified 86 case reports connecting the use of SSRIs with the development of dystonia, parkinsonism, dyskinesia, & akathisia." https://t.co/HpoNKCG3G6 @MDPIOpenAccess

Sep 21, 2022 · 1 like · 2 shares · 6,494 followers View post →
Neurology International
@neurolint_mdpi · X

#mdpiNeurolint Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review #depression #psychology

Sep 11, 2021 · 158 followers View post →