August 2021 PMID 34459130

Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals.

Yanyu Jiang, Xi Yang, Changsheng Dong, Yun Lu, Hongmei Yin, Biying Xiao, Xuguang Yang, Wenlian Chen, Wei Cheng, Hechuan Tian, Lin Guo, Xiaobo Hu, Hong Fang, Weiqin Chen, Zhen Li

Mentions

79
Peak: 45 in Sep 2021
across 5 sources since Aug 2021

Extended reach

706,925
potential audience

Total likes

276

Video views

1,586

Mentions per month

Aug 2021 – Jun 2025

Where it's discussed

  • X / Twitter68 posts
  • News4 articles
  • YouTube3 videos
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Participants engaged in discussions about the study's findings, mentioning points like the decreased risk factors for metabolic syndrome and potential health benefits, often using phrases like 'great metabolic tune-up' and 'unbelievable effects'. The tone varies, with some expressing enthusiasm and others caution, particularly emphasizing that fasting should be guided by clinical professionals.

AgreementModerate agreement

There is a general consensus that the publication presents valuable findings, though some express caution regarding its application.

InterestHigh interest

Many discussions highlight curiosity about the topic, showcasing a strong desire to learn more about fasting and its implications.

EngagementModerate engagement

While some posts show deeper discussion about the research methods and results, others appear more superficial, simply echoing the findings.

ImpactHigh impact

Participants regard the findings as significant, indicating potential benefits for health and wellness.

Abstract in brief

  • A five-day water-only fast was linked to decreased risk factors for metabolic syndrome in healthy, normal-weight individuals.
  • The fasting led to an increase in anti-aging biomarkers, suggesting potential health benefits.
  • No significant toxicity or adverse effects were reported during the clinical trial.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight people 4.5 kg weight loss insulin and blood pressure down cholesterol and LDL up(!) h/t @mike_lustgarten https://t.co/dHBL572IAX

Sep 1, 2021 · 155 likes · 28 shares · 291,941 followers View post →
Abu Hanan
@hanan052020 · X

Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu oleh tim klinis dan mungkin tidak berlaku untuk populasi umum [https://t.co/LncNj7Dxga] https://t.co/wgGhk1SbDo https://t.co/SlBA2PKNsE

Jan 29, 2025 · 30 likes · 6 shares · 1,189 followers View post →
Agingdoc
@agingdoc1 · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals https://t.co/bQFZ3Hpj2T

Sep 9, 2021 · 16 likes · 5 shares · 41,667 followers View post →
Larry Diamond
@natureboyrr · X

“Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals.” @FastingMethod The benefits well beyond fat loss. Great metabolic tuneup https://t.co/8uqOQOf3yn

Sep 12, 2021 · 16 likes · 7 shares · 5,626 followers View post →
Aleksandra Stęplowska
@stepelka · X

5‐day water‐only fasting has many critical beneficial effects without toxicity via: Clin Transl Med *"water‐only fasting should be guided by clinical team and may not be applicable to general populations" https://t.co/kHt9ttSHym https://t.co/tQGQUl6ybS

Aug 23, 2021 · 5 likes · 3 shares · 2,781 followers View post →
ju
@enavarac · X

j’ai trouvé une étude qui vante le mérite du vrai jeûne sur de courtes durées, mais jamais rien qui montre que le jeûne intermittent marchait. le seul truc que j’ai vu c’est un jeûne « intermittent » ou tu ne grignotes pas le soir étude sur le jeûne : https://t.co/B3wrZMkWNI https://t.co/HCl3NezWGJ

May 17, 2022 · 3 likes · 449 followers View post →

All mentions

Osman Tuna
@OsmanTunaF · X

@agirsaglam Bazı durumlarda gerçekçi faydaları var. Kısa formu (48-72 saat) faydaları daha iyi çalışılmış ama bunla ilgili de araştırmalar var. Doi: 10.3390/nu14061183. PMID: 35334843; PMCID: PMC8951503. DOI: 10.1002/ctm2.502 DOI : 10.3390/nu16223959. PMID: 39599745; PMCID: PMC11597177.

Jun 10, 2025 · 93 followers View post →
Marmoris
@R_Marmoris · X

RT @hanan052020: Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu o…

Jan 30, 2025 · 6 shares · 104 followers View post →
Dea
@deadira · X

RT @hanan052020: Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu o…

Jan 30, 2025 · 6 shares · 545 followers View post →
TheMoon
@levituathade · X

RT @hanan052020: Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu o…

Jan 30, 2025 · 6 shares · 78 followers View post →
Arin Aristia
@arinaristia · X

RT @hanan052020: Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu o…

Jan 30, 2025 · 6 shares · 5,035 followers View post →
Abu Hanan
@hanan052020 · X

Tolong ya, jangan sekali-kali lakukan ini.. apalagi kl keseringan.. Pada intinya: Puasa dg minum air saja harus dipandu oleh tim klinis dan mungkin tidak berlaku untuk populasi umum [https://t.co/LncNj7Dxga] https://t.co/wgGhk1SbDo https://t.co/SlBA2PKNsE

Jan 29, 2025 · 30 likes · 6 shares · 1,189 followers View post →
Dr. Günaşık
@MrsZngn · X

RT @hknerdr: @_Analizci_ https://t.co/YV1XZQvRGX

Nov 1, 2024 · 1 share · 1,001 followers View post →
Hakan Erdur
@hknerdr · X

@_Analizci_ https://t.co/YV1XZQvRGX

Oct 31, 2024 · 1 like · 1 share · 421 followers View post →
Timetraveller
@Deus__Maximus · X

@theliverdr He is a doctor as much qualified as you if not more , you are an influencer as much as him. Your double colonized bigotry targeting him is for typical reasons ie his pro Indic culture. Chinese Natural science researchers are disproving you. https://t.co/6CocX4xLrX

Nov 1, 2023 · 281 followers View post →
Fire and Desert | I teach fasting
@FastingMastery · X

Five‐day water‐only #fasting decreased metabolic‐syndrome risk factors and increased #anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals https://t.co/Y99xZBawez

Jan 20, 2023 · 12 followers View post →
Orlando_uy
@Orlando_uy · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals https://t.co/Gba6AvUHqL

Oct 22, 2022 · 694 followers View post →
ju
@enavarac · X

j’ai trouvé une étude qui vante le mérite du vrai jeûne sur de courtes durées, mais jamais rien qui montre que le jeûne intermittent marchait. le seul truc que j’ai vu c’est un jeûne « intermittent » ou tu ne grignotes pas le soir étude sur le jeûne : https://t.co/B3wrZMkWNI https://t.co/HCl3NezWGJ

May 17, 2022 · 3 likes · 449 followers View post →
Robzs13
@Robzs13 · X

@Esban_ @ARTEfr https://t.co/H3q9j4vnU8

Mar 14, 2022 · 76 followers View post →
Rrichha Aroraa
@ArroraRichhaa06 · X

RT @sidkhullar: Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity…

Feb 15, 2022 · 2 shares · 274 followers View post →
rajeev khullar
@rajeevkhullar20 · X

RT @sidkhullar: Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity…

Feb 15, 2022 · 2 shares · 510 followers View post →
SidK
@if90_fit · X

Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals https://t.co/JBFdCVMge3

Feb 15, 2022 · 594 followers View post →
Siddhartha Khullar
@sidkhullar · X

Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals https://t.co/dNA5f2KysO

Feb 15, 2022 · 2 likes · 2 shares · 8,346 followers View post →
Nick Urban
@nicholasurban_ · X

Unsurprising, but nice seeing "healthy" populations studied more https://t.co/otuhV3lBF7

Oct 5, 2021 · 97 followers View post →
NOMIX
@NOMIX_AI · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals #longevity #personalomics #nomix https://t.co/c8FbAST9WT

Oct 5, 2021 · 1 like · 595 followers View post →
inaco
@lazilydefiant · X

RT @agingdoc1: Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity i…

Sep 12, 2021 · 5 shares View post →
imnotacat
@lindy09 · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 506 followers View post →
Ensio Kallio
@EnsioKallio · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 629 followers View post →
Santiago Navarro
@Santiag86836414 · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 513 followers View post →
Xenon
@CO2caine · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 549 followers View post →
Martin Von Mars
@mvonmars · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 136 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @natureboyrr: “Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicit…

Sep 12, 2021 · 7 shares · 158,501 followers View post →
Larry Diamond
@natureboyrr · X

“Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals.” @FastingMethod The benefits well beyond fat loss. Great metabolic tuneup https://t.co/8uqOQOf3yn

Sep 12, 2021 · 16 likes · 7 shares · 5,626 followers View post →
The Phoenix Lab
@The_Phoenix_Lab · X

RT @agingdoc1: Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity i…

Sep 12, 2021 · 5 shares · 210 followers View post →
Frank Butler
@sohoherbs · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals - Jiang - 2021 - Clinical and Translational Medicine - Wiley Online Library https://t.co/pI4bRCfAbH

Sep 9, 2021 · 1 like · 190 followers View post →
Ricky
@ricky89449195 · X

RT @agingdoc1: Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity i…

Sep 9, 2021 · 5 shares · 311 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @agingdoc1: Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity i…

Sep 9, 2021 · 5 shares · 77 followers View post →
Longevity Wiki
@longevitywiki · X

Secrets Of What A Five-day Water-Only Fasting Might Do For You

Sep 9, 2021 · 554 followers View post →
AgingResearch
@TheAgingField · X

RT @agingdoc1: Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity i…

Sep 9, 2021 · 5 shares · 5,261 followers View post →
Orlando_uy
@Orlando_uy · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals https://t.co/TI7tyRZAmm

Sep 9, 2021 · 1 like · 694 followers View post →
Agingdoc
@agingdoc1 · X

Five‐day water‐only fasting decreased metabolic‐syndrome risk factors and increased anti‐aging biomarkers without toxicity in a clinical trial of normal‐weight individuals https://t.co/bQFZ3Hpj2T

Sep 9, 2021 · 16 likes · 5 shares · 41,667 followers View post →
karush
@scarfacehood · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 8, 2021 · 28 shares · 492 followers View post →
Magnum
@watchfuldefend · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 3, 2021 · 28 shares · 3,688 followers View post →
Kuro Midori
@5thRing · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 3, 2021 · 28 shares · 152 followers View post →
Haroldo Falcão, MD
@haroldofalcao · X

Tô dizendo... https://t.co/Op9INOz2ad HT @dj_surfista

Sep 3, 2021 · 2 likes · 609 followers View post →
Stefan Sladeček
@stefansladecek · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 2, 2021 · 28 shares · 274 followers View post →
 Silver Fox
@Estibi31 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 2, 2021 · 28 shares · 5,376 followers View post →
Jayson Merlino ©
@mindcrook · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 2, 2021 · 28 shares · 285 followers View post →
Sunset HQ
@SunsetHQBC · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 15 followers View post →
No One of Consequence
@ImdaVinman · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 1,576 followers View post →
James Wright
@JamesGaius · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 470 followers View post →
Maurício Lima
@dj_surfista · X

O #jejum de 5 dias apenas com água diminuiu os fatores de risco da síndrome metabólica e aumentou os biomarcadores antienvelhecimento sem toxicidade em um ensaio clínico com indivíduos com peso normal. #fasting https://t.co/2NCZsnH1pu

Sep 1, 2021 · 1 like · 742 followers View post →
Bob Paul
@bobepaul · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 924 followers View post →
C
@nayitis · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 341 followers View post →
Santiago Navarro
@Santiag86836414 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 513 followers View post →
johnnylaw.dgb
@JohnnyLaw2021 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 6,096 followers View post →
Mark Bski
@MarkBski · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 8,240 followers View post →
ZKA
@0knowledgeactor · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 1,161 followers View post →
paengineer
@paengineer · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 2,586 followers View post →
guru
@badaguru1 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 167 followers View post →
Paul Lucas
@flukielucas · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 53 followers View post →
JRod Freedom
@JrodFreedom · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 608 followers View post →
Kulpable
@Kulpable2 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 144 followers View post →
Dmitry
@argutic8 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 368 followers View post →
Eternally Offended
@EternalyOfended · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 29 followers View post →
Orest Bulcano
@dekentro · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 1,026 followers View post →
Isegoria
@Isegoria · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 1,641 followers View post →
Scott A McMillan
@scott4670 · X

RT @Mangan150: 5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight peop…

Sep 1, 2021 · 28 shares · 4,372 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

5 day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers in normal-weight people 4.5 kg weight loss insulin and blood pressure down cholesterol and LDL up(!) h/t @mike_lustgarten https://t.co/dHBL572IAX

Sep 1, 2021 · 155 likes · 28 shares · 291,941 followers View post →
DesignedByNature
@DesignedNature · X

Posting "Five-day water-only fasting decreased metabolic-syndrome risk factors and increased anti-aging biomarkers without toxicity in a clinical trial of normal-weight individuals. (Pub Date: 2021-08)" on reddit #ketoscience https://t.co/VSIuj0ydpl

Aug 31, 2021 · 439 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @stepelka: 5‐day water‐only fasting has many critical beneficial effects without toxicity via: Clin Transl Med *"water‐only fasting sh…

Aug 23, 2021 · 3 shares · 2,879 followers View post →
ScienceStop
@B0tSci · X

RT @stepelka: 5‐day water‐only fasting has many critical beneficial effects without toxicity via: Clin Transl Med *"water‐only fasting sh…

Aug 23, 2021 · 3 shares · 4,073 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @stepelka: 5‐day water‐only fasting has many critical beneficial effects without toxicity via: Clin Transl Med *"water‐only fasting sh…

Aug 23, 2021 · 3 shares · 123,748 followers View post →
Aleksandra Stęplowska
@stepelka · X

5‐day water‐only fasting has many critical beneficial effects without toxicity via: Clin Transl Med *"water‐only fasting should be guided by clinical team and may not be applicable to general populations" https://t.co/kHt9ttSHym https://t.co/tQGQUl6ybS

Aug 23, 2021 · 5 likes · 3 shares · 2,781 followers View post →