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Signal Transduct Target Ther September 2021 PMID 34489403

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.

Ling Zhang, Li Zhou, Linlin Bao, Jiangning Liu, Hua Zhu, Qi Lv, Ruixue Liu, Wei Chen, Wei Tong, Qiang Wei, Yanfeng Xu, Wei Deng, Hong Gao, Jing Xue, Zhiqi Song

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Mentions

63
Peak: 27 in Oct 2021
across 4 sources since Sep 2021

Extended reach

112,389
potential audience

Total likes

83

Video views

198

Mentions per month

Sep 2021 – Mar 2025

Where it's discussed

  • X / Twitter47 posts
  • Reddit8 posts
  • News6 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions consistently praise the article for revealing how SARS-CoV-2 infiltrates the brain via basement membrane disruption, with phrases like 'supports the brain invasion mechanism' and 'highly relevant for COVID-19 neurological symptoms' showing both support and interest. The tone suggests that the community sees this as a breakthrough with significant health implications, prompting active and focused exchanges about its relevance and mechanisms.

AgreementStrong agreement

Most discussions fully support and emphasize the significance of the findings, reinforcing consensus on the virus's mechanism of crossing the blood-brain barrier.

InterestHigh interest

The posts show high curiosity and focus on the implications, with many referencing the mechanism and potential health impacts.

EngagementModerate engagement

While many posts are supportive and share details about the mechanisms, few deeply analyze methodologies or broader consequences, reflecting moderate engagement.

ImpactHigh impact

Discussion highlights the potential importance of this discovery for understanding COVID-19’s neurological effects, indicating high impact.

Abstract in brief

  • SARS-CoV-2 can cross the blood-brain barrier (BBB) without damaging the tight junctions but disrupts the basement membrane, enabling virus entry into the brain.
  • The virus infects and passes through brain microvascular endothelial cells (BMECs), increasing vessel permeability and causing inflammatory responses like vasculitis and glial activation.
  • The process involves a transcellular pathway where the basement membrane is broken down, while tight junction proteins remain unchanged, highlighting a specific mechanism of brain invasion by the virus.]
Read the full abstract

Top posts

Most liked on X and Bluesky
avivi
@avivi · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/WyVlefyrpV @MackayIM @profshanecrotty @VirusesImmunity @Dereklowe @mugecevik @CT_Bergstrom @EricTopol @florian_krammer @GidMK https://t.co/TpVswydbs3

Oct 22, 2021 · 65 likes · 27 shares · 248 followers View post →
Blood brain barrier
@bbbpapers · X

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/UwMSaS4eR0

Sep 8, 2021 · 4 likes · 1 share · 775 followers View post →
内田
@uchida_kawasaki · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration | Signal Transduction and Targeted Therapy https://t.co/OBrRcCLMFI SARS-CoV-2は、密着結合を変化させることなく、基底膜の破壊を伴う血液脳関門を通過します

Oct 1, 2021 · 3 likes · 2 shares · 1,935 followers View post →
SourceControl21
@SourceControl21 · X

https://t.co/wYvLxdep8Z

Feb 16, 2023 · 3 likes · 3 shares · 864 followers View post →
DrRPalmquist
@DrPalmquist · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/S23cC2lFDU

Apr 27, 2024 · 2 likes · 1 share · 3,159 followers View post →
THE MAC
@NotTheMacAnon1 · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption ... by L Zhang · 2021 · Cited by 263 — SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals

Feb 14, 2025 · 1 like · 3,789 followers View post →

All mentions

SourceControl21
@SourceControl21 · X

RT @SourceControl21: https://t.co/wYvLxdep8Z

Mar 2, 2025 · 3 shares · 864 followers View post →
THE MAC
@NotTheMacAnon1 · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption ... by L Zhang · 2021 · Cited by 263 — SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals

Feb 14, 2025 · 1 like · 3,789 followers View post →
Mary Christine Lisether
@FrkTeigen · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration - PMC (https://t.co/L1UYSijoNF)

May 30, 2024 · 6,653 followers View post →
Dr. Suzana Mantovani
@Tweet_Nutrition · X

RT @DrPalmquist: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteratio…

Apr 27, 2024 · 1 share · 4,579 followers View post →
DrRPalmquist
@DrPalmquist · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/S23cC2lFDU

Apr 27, 2024 · 2 likes · 1 share · 3,159 followers View post →
THE MAC
@NotTheMacAnon1 · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

Feb 5, 2024 · 3,789 followers View post →
Jennifer Jones
@Jennifer_Jo1234 · X

@Melchizedek1972 @RobertKennedyJr https://t.co/drDw1UpbC9

Jun 29, 2023 · 1 like · 440 followers View post →
Algorithmus22
@Algorithmus22 · X

RT @SourceControl21: https://t.co/wYvLxdep8Z

Mar 1, 2023 · 3 shares · 741 followers View post →
SourceControl21
@SourceControl21 · X

https://t.co/wYvLxdep8Z

Feb 16, 2023 · 3 likes · 3 shares · 864 followers View post →
KATHY FRAMARINI
@KFramarini · X

UNIVERSITY OF FLORIDA SHANDS-NEUROLOGY RICK SCOTT.

Aug 27, 2022 · 3 followers View post →
Chris O'Leary | The Innovation Podcast
@InnoTalker · X

"SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration" https://t.co/gbuet0oLWO Note the assumption that the only way in to the brain is THROUGH the B-BB. And not AROUND it. When you assume...

Mar 11, 2022 · 139 followers View post →
newswatch4u
@newswatch4u · X

RT @Marieaaow: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration…

Jan 23, 2022 · 2 shares · 570 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

RT @Marieaaow: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration…

Jan 23, 2022 · 2 shares · 14,505 followers View post →
Dr.M.A.A.O.W.
@Marieaaow · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/vdDfuYZbi2

Jan 23, 2022 · 2 shares · 14,505 followers View post →
Loose Unit Prole Sewer Rat
@PatrickDeane11 · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration | Signal Transduction and Targeted Therapy https://t.co/XHICw894rA

Jan 15, 2022 · 1,648 followers View post →
Kristin Whiteley
@causalitybrunch · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration | Signal Transduction and Targeted Therapy https://t.co/81NqubOfI3

Jan 15, 2022 · 1,377 followers View post →
Gunhild Alvik Nyborg, MD, PhD, BSc
@GANyborg · X

@nilaug @dagsvanaes @akravik79 @ROttervik @ingvildkjerkol @Prebens @camisto @HalSandberg @NTNUhelse @GunnarKv @SteinarWestin @DThelle @bguldvog SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/rcvmV12LM8

Nov 11, 2021 · 6,893 followers View post →
タナカ　リョウイチ
@ryoichi_tanaka · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/VN9UmUK9Ih

Nov 4, 2021 · 1,717 followers View post →
Dr. DM, MD
@daria_mir · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 24, 2021 · 27 shares · 245 followers View post →
Ben Gera
@BenGera9 · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 188 followers View post →
Denkmalstift
@denkmalstift · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 808 followers View post →
Thomas Meinhardt
@MeinhardtThomas · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 601 followers View post →
D'Ombre et de Lumière
@louvetou · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 132 followers View post →
Emma
@angelofderby · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 226 followers View post →
Dave
@icestormfr · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 1,024 followers View post →
Danielle
@jabings2 · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 23, 2021 · 27 shares · 915 followers View post →
Indy
@indy_yet · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 2,879 followers View post →
Mike Cane
@mikecane · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 974 followers View post →
THE DROPLET DIARIES
@DropletDiaries · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 1,979 followers View post →
Wolfgang Keil
@WOLKEFN · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 1,516 followers View post →
TorroTheWing Ilmari Pallas
@TorroWing · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 58 followers View post →
Gris
@degogrim · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 59 followers View post →
Laura
@SixandLaura · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 3,034 followers View post →
DavidPa91620835
@DavidPa91620835 · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 1,158 followers View post →
Bożena Elżbieta
@bozena_elzbieta · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 114 followers View post →
nope
@maybedana · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 273 followers View post →
lexilicious
@lexilicious8 · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 57 followers View post →
Lonnie R Marcum, PT, BSHCA
@LonnieRhea · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 3,806 followers View post →
Dayra Escudero Pérez
@dayraaaaaaaaaa · X

RT @avivi: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration htt…

Oct 22, 2021 · 27 shares · 738 followers View post →
avivi
@avivi · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/WyVlefyrpV @MackayIM @profshanecrotty @VirusesImmunity @Dereklowe @mugecevik @CT_Bergstrom @EricTopol @florian_krammer @GidMK https://t.co/TpVswydbs3

Oct 22, 2021 · 65 likes · 27 shares · 248 followers View post →
Kursad Turksen
@kursadturksen · X

#TISSUEBARRIERS SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions al… https://t.co/6GY9HbXzzz

Oct 18, 2021 · 231 followers View post →
StillMe
@dutchess_becky · X

"SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration | Signal Transduction and Targeted Therapy" https://t.co/ydER6Td7v0

Oct 11, 2021 · 432 followers View post →
so　sora
@sosorasora3 · X

RT @uchida_kawasaki: SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alter…

Oct 1, 2021 · 2 shares · 17,244 followers View post →
内田
@uchida_kawasaki · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration | Signal Transduction and Targeted Therapy https://t.co/OBrRcCLMFI SARS-CoV-2は、密着結合を変化させることなく、基底膜の破壊を伴う血液脳関門を通過します

Oct 1, 2021 · 3 likes · 2 shares · 1,935 followers View post →
Michael Schulz #6G
@MichiSchulz89 · X

RT @bbbpapers: SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration…

Sep 8, 2021 · 1 share · 484 followers View post →
Blood brain barrier
@bbbpapers · X

SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/UwMSaS4eR0

Sep 8, 2021 · 4 likes · 1 share · 775 followers View post →
Paul McCullough
@ThePostsynaptic · X

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration https://t.co/O9VYDWGV6h https://t.co/HSB4VcB7Sl

Sep 7, 2021 · 2,590 followers View post →