#OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress testing) was associated with ⬆️ risk of death. Invasive management did not ⬇️ risk in any group. https://t.co/2a3s7odZ6S @lesleejshaw #AHAJournals https://t.co/yG4QjjExmH
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.
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Sep 2021 – Oct 2024Where it's discussed
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X / Twitter98 posts
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News6 articles
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YouTube5 videos
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Facebook2 posts
AI synopsis
What people are saying
The discussions include specific mentions of the challenges around comparing invasive versus conservative treatment strategies, highlighting points such as 'plaque burden, not the degree of obstruction predicts outcome' and 'the invasive strategy resulted in significantly lower cardiovascular death and MI.' The tone of these discussions is analytical, with phrases like 'requires careful consideration' and 'important implications' revealing a thoughtful engagement with the material.
The majority of discussions reflect a consensus that the findings of the ISCHEMIA trial are valuable, although some express questions and clarifications.
Participants show strong interest in the topics highlighted by the ISCHEMIA trial, indicating it is a relevant issue in their field.
There are a range of responses, from simple acknowledgments to in-depth analyses of the trial's methodologies and implications.
Many users perceive the findings to have significant implications for clinical practices related to coronary artery disease and revascularization strategies.
Abstract in brief
- The ISCHEMIA trial aimed to determine if patients with stable coronary artery disease (CAD) and significant ischemia would benefit from revascularization compared to conservative treatment.
- A total of 5,179 patients with moderate to severe ischemia were randomized to either an invasive or conservative management approach, allowing researchers to assess outcomes based on the severity of ischemia and CAD.
- Results indicated that neither moderate nor severe ischemia was linked to increased mortality rates, though severe ischemia was associated with higher nonfatal myocardial infarction (MI) rates and more severe CAD correlated with increased death and MI risk.
Top posts
Most liked on X and BlueskyThank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this team My takeaways: 1) #ISCHEMIA captured current landscape of functional testing & put anatomy vs ischemia discussions in the center https://t.co/lM3mkfOIF2 https://t.co/m5WMYAPaz6
Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/b63pw0O10w @cmolinerabos @AreaHjt @josejgdnews @alba_mabe @CardioBCN @LopezOpitz @rafavidalperez @xgmoll
Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity. Unusual… https://t.co/PcAeF0la5Z
@GEICC3 @GreggWStone @DavidLBrownMD @webmd11 @ajaykirtane @SrihariNaiduMD @JEscaned @sbrugaletta @MarcoJe80135689 My interpretation of this ISCHEMIA substudy https://t.co/nXJk3HYRci was that the invasive strategy resulted in significantly lower cardiovascular death and MI in patients with more severe CAD involving the proximal LAD.
All mentions
Comparison of Invasive and Conservative Strategies for Stable Coronary Disease
This week in cardiology, we explore prediction models versus clinical judgment, CCTA quantification of atherosclerosis, and the latest on AF ablation, LAAO devices, and HF therapy. The study compares invasive and…
Outcomes of Stable Coronary Artery Disease Treatment Options
The ISCHEMIA trial aimed to determine if patients with stable coronary artery disease and significant ischemia benefit from revascularization compared to conservative treatment. This video discusses outcomes based on…
Outcomes of ISCHEMIA Trial and Revascularization Insights
Bob Harrington interviews Jacqueline Tamis-Holland on the ISCHEMIA trial, which explores revascularization's role in stable coronary artery disease. The study reveals that severe ischemia correlates with higher nonfatal…
Evaluating Antiplatelet Therapy Duration in High Bleeding Risk Patients
This week's podcast discusses the importance of dual antiplatelet therapy duration for patients at high bleeding risk after drug-eluting stent placement. The study explores abbreviated therapy effectiveness compared to…
ISCHEMIA Trial Insights: Management of Coronary Artery Disease Outcomes
This podcast discusses the ISCHEMIA trial's findings on patients with stable coronary artery disease and ischemia. It explores the implications of these results for invasive versus conservative treatment strategies…
RT @VictorDayan1: @DFCapodanno @ESC_Journals @TCTMD @PCRonline I believe this data was already published on 2021 at @CircAHA. What is the d…
RT @VictorDayan1: @DFCapodanno @ESC_Journals @TCTMD @PCRonline I believe this data was already published on 2021 at @CircAHA. What is the d…
RT @VictorDayan1: @DFCapodanno @ESC_Journals @TCTMD @PCRonline I believe this data was already published on 2021 at @CircAHA. What is the d…
@DFCapodanno @ESC_Journals @TCTMD @PCRonline I believe this data was already published on 2021 at @CircAHA. What is the difference with the @EuroInterventio paper ? @drjohnm @FaisalBakaeen https://t.co/fdWHmWVmMr
@oliveiraeduar @DFCapodanno
lower 4-year rate of cardiovascular death or MI among participants assigned to the invasive strategy within the most severe anatomic CAD subgroup driven by lower rates of spontaneous MI, albeit with no adjustment for multiple testing https://t.co/RkZCcNsfUP https://t.co/ArXO4xQEjZ
RT @VictorDayan1: @DavidLBrownMD @EduQuintanaCVS @ACCinTouch ISCHEMIA trial. My mistake: CV mortality or MI. https://t.co/3T8Q4exvZx
RT @Cardiobro: Plaque burden, not the degree of obstruction predicts outcome Ischemia severity was not associated with AE after adjusting f…
Plaque burden, not the degree of obstruction predicts outcome Ischemia severity was not associated with AE after adjusting for CAD severity ⏫severe CAD was associated with ⏫ risk for all-cause mortality but invasive strategy did not ⏬ risk @ 4 years https://t.co/KRDLkVh22Q
@DavidLBrownMD @EduQuintanaCVS @ACCinTouch ISCHEMIA trial. My mistake: CV mortality or MI. https://t.co/3T8Q4exvZx
REFERENCES 1. Original ISCHEMIA results publication: 10.1056/NEJMoa1915922 2. HF subgroup analysis: 10.1161/CIRCULATIONAHA.120.050304 3. ISCHEMIA population ischemia severity: 10.1161/CIRCULATIONAHA.120.049755 Clinical implications (2021 review) 1. 10.1007/s11886-021-01470-x
@bennoormd @VivekKulkarniMD Very true. This analysis supports your point about looking at extent of CAD too https://t.co/UdHDinQWDp
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
RT @mirvatalasnag: Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this…
Thank u @Heart_SCCT @jolson106 Was an honor serving on #ASM committee #SCCT2022 & congrats @ghoshhajra for leading this team My takeaways: 1) #ISCHEMIA captured current landscape of functional testing & put anatomy vs ischemia discussions in the center https://t.co/lM3mkfOIF2 https://t.co/m5WMYAPaz6
RT @SABOURETCardio: Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity. Unusual… https://…
RT @SABOURETCardio: Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity. Unusual… https://…
Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity @CircAHA https://t.co/uwtHwaxbBH
RT @SABOURETCardio: Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity. Unusual… https://…
Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity. Unusual… https://t.co/PcAeF0la5Z
Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity @CircAHA https://t.co/tSnIvGqypb
@GEICC3 @GreggWStone @DavidLBrownMD @webmd11 @ajaykirtane @SrihariNaiduMD @JEscaned @sbrugaletta @MarcoJe80135689 My interpretation of this ISCHEMIA substudy https://t.co/nXJk3HYRci was that the invasive strategy resulted in significantly lower cardiovascular death and MI in patients with more severe CAD involving the proximal LAD.
@AnkurKalraMD https://t.co/pfW8CKFwFS
@AnkurKalraMD @djc795 Thank you both for your input. It did not. This was from a secondary analysis https://t.co/C3ykyDgLe1
RT @djc795: @kaulcsmc @VictorDayan1 @gbiondizoccai @US_FDA @webmd11 @DavidLBrownMD @SripalBangalore @drjohnm Most of the answers to your qu…
RT @djc795: @kaulcsmc @VictorDayan1 @gbiondizoccai @US_FDA @webmd11 @DavidLBrownMD @SripalBangalore @drjohnm Most of the answers to your qu…
@kaulcsmc @VictorDayan1 @gbiondizoccai @US_FDA @webmd11 @DavidLBrownMD @SripalBangalore @drjohnm Most of the answers to your questions are in this paper... https://t.co/nOfbDDmu8E
RT @paomorejon: https://t.co/ELV7kpQU5z
RT @paomorejon: https://t.co/ELV7kpQU5z
https://t.co/ELV7kpQU5z
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
RT @DavidVilades: More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery…
More evidence about what really matters: CAD instead of Ischemia. Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/b63pw0O10w @cmolinerabos @AreaHjt @josejgdnews @alba_mabe @CardioBCN @LopezOpitz @rafavidalperez @xgmoll
@mmamas1973 @SGuptaMD @ShariqShamimMD @ajaykirtane @KoushikReddyMD @purviparwani @SandeepNathanMD @Jonathan_PaulMD @jedicath @aymanka @atunuguntla1 Agree with @mmamas1973 and @cpgale3 although some evidence from #ISCHEMIA of interaction in those with most severe CAD in favour of early invasive approach. Hypothesis generating and not clear how apparent benefit is mediated - CABG? https://t.co/ysCLbCeKGu
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/A6QiHzqHVC https://t.co/a3Y8G6yMij
RT @vicatallah: Resultados ISCHEMIA enfermedad arterial coronaria (EAC) estable e isquemia moderada o grave. Concluye: gravedad isquemia n…
Resultados ISCHEMIA enfermedad arterial coronaria (EAC) estable e isquemia moderada o grave. Concluye: gravedad isquemia no se asoció mayor riesgo post ajuste gravedad EAC. Terapia invasiva no redujo mortalidad todas causas 4 años en ningún subgrupo #VEA https://t.co/8tg8aqHc3n
RT @senthil_selv: @pebravov @CoronaryDoc @Open_HeartBMJ @RBP0612 @khurramn1 @tomkaier @DrPascalMeier @BritishCardioSo @RonBlankstein @purvi…
RT @senthil_selv: @pebravov @CoronaryDoc @Open_HeartBMJ @RBP0612 @khurramn1 @tomkaier @DrPascalMeier @BritishCardioSo @RonBlankstein @purvi…
RT @senthil_selv: @pebravov @CoronaryDoc @Open_HeartBMJ @RBP0612 @khurramn1 @tomkaier @DrPascalMeier @BritishCardioSo @RonBlankstein @purvi…
RT @senthil_selv: @pebravov @CoronaryDoc @Open_HeartBMJ @RBP0612 @khurramn1 @tomkaier @DrPascalMeier @BritishCardioSo @RonBlankstein @purvi…
@pebravov @CoronaryDoc @Open_HeartBMJ @RBP0612 @khurramn1 @tomkaier @DrPascalMeier @BritishCardioSo @RonBlankstein @purviparwani @AChoiHeart @ErinMichos @BSCImaging @DrMarthaGulati A3. A timely question given recent data from ISCHEMIA trial showing coronary burden more prognostically relevant than ischemia #openheartjc @CoronaryDoc @pebravov @CircAHA https://t.co/ttVbjnGxQa
RT @ChiznerRyan: In the ISCHEMIA trial, people with stable coronary artery disease lacked benefit from revascularization regardless of whet…
In the ISCHEMIA trial, people with stable coronary artery disease lacked benefit from revascularization regardless of whether they had mild or severe ischemia. https://t.co/NbM6nCllt2
RT @jamamepy: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/De8IlQ0OjD
https://t.co/u71CbHaujG
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/De8IlQ0OjD
RT @CardioIAN: @CardioIAN #CardioTwitter @MihaiTrofenciuc @pabeda1 https://t.co/kFmgQn4mdV
RT @SantasEnrique: Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
@CardioIAN #CardioTwitter @MihaiTrofenciuc @pabeda1 https://t.co/kFmgQn4mdV
RT @SantasEnrique: Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity | Circulation https://t.co/wVpkgEy9yJ
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @irjpnmEqqEUJraX: Circulation 2021; ISCHEMIAのサブ解析 https://t.co/D6fDMOAbOu 中等度~高度心筋虚血のある安定狭心症への侵襲治療と保存的加療の比較。全体では死亡・MIに差なし。虚血の程度は介入効果を修飾し…
Circulation 2021; ISCHEMIAのサブ解析 https://t.co/D6fDMOAbOu 中等度~高度心筋虚血のある安定狭心症への侵襲治療と保存的加療の比較。全体では死亡・MIに差なし。虚血の程度は介入効果を修飾しない。重度CADのsubgroupでは全死亡に差ないが、CV死とMIは侵襲治療で減少。虚血は予後予測せず。
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
Anatomy trumps ischaemia (again) #CardioTwitter #FOAMed https://t.co/RZVyWAG15H
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @SantasEnrique: Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
RT @SantasEnrique: Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
Grado de isquemia miocárdica eventos en el #ischemia trial @CircAHA
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
RT @CircAHA: #OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress t…
#OriginalResearch In the ISCHEMIA trial, CAD severity (multivessel, >70% stenosis etc.) but not ischemia severity (on stress testing) was associated with ⬆️ risk of death. Invasive management did not ⬇️ risk in any group. https://t.co/2a3s7odZ6S @lesleejshaw #AHAJournals https://t.co/yG4QjjExmH
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity - https://t.co/MUczTwkXak
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity - https://t.co/PTFNSObUrK
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://t.co/sdcOKy0rS8