JACC Cardiovasc Interv September 2021 PMID 34556269

ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION): A Randomized Clinical Trial.

Tiffany Patterson, Tim Clayton, Matthew Dodd, Zeeshan Khawaja, Marie Claude Morice, Karen Wilson, Won-Keun Kim, Nicolas Meneveau, Rainer Hambrecht, Jonathan Byrne, Didier Carrié, Doug Fraser, David H Roberts, Sagar N Doshi, Azfar Zaman

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Mentions

Peak: 54 in Sep 2021

across 4 sources since Sep 2021

Extended reach

504,296

potential audience

Total likes

209

Video views

Mentions per month

Sep 2021 – Sep 2024

Where it's discussed

X / Twitter65 posts
News6 articles
YouTube2 videos
Facebook2 posts

AI synopsis

What people are saying

Several discussions provide insights into the trial, highlighting points like the higher incidence of bleeding observed in the PCI group while death and rehospitalization rates remained similar. Users cited phrases like 'conservative management may be warranted,' which reflects a careful consideration of outcomes. The tone of excitement and urgency indicates that many see the findings as pivotal, evidenced by mentions of 'interesting' and anticipatory remarks about future trials.

AgreementModerate agreement

Most discussions indicate support for the trial's findings, with users emphasizing that the results were consistent with existing studies.

InterestHigh interest

There is a strong curiosity evident in the tone and phrasing of the posts, suggesting the topic resonates well with the audience.

EngagementModerate engagement

Several posts delve into the trial's methodologies and implications, though some responses remain surface-level.

ImpactHigh impact

Users widely believe the findings will affect future treatment strategies in elderly patients with aortic stenosis.

Abstract in brief

This study evaluated the effectiveness of performing percutaneous coronary intervention (PCI) before transcatheter aortic valve replacement (TAVR) in patients with significant coronary artery disease compared to those who didn't receive PCI.
While the one-year outcomes for all-cause death and rehospitalization were similar between the PCI and no-PCI groups, the study did not meet its noninferiority threshold.
Additionally, the PCI group experienced a higher incidence of bleeding, even though rates of other complications like stroke and myocardial infarction were comparable between the two groups.

Read the full abstract

All mentions

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Felipe Díez del Hoyo

@Felipediezhoyo · X

Sep 1, 2024 · 1 like · 23,902 followers View post →

Josh Wilcox

@jdrwilcox · X

@TharushaGunawa4 Hopefully the ACTIVATION trial was mentioned?! Important data to know about… @drtpatterson @drsimonredwood. Recruiting for 7 years! Does mean some caution required - mean age 84yo. Fair numbers bare metal stents and VG PCI - both less common today… https://t.co/ugYEJlKDnu https://t.co/J2cU9admCq

Feb 1, 2024 · 1,137 followers View post →

David J. Cohen, MD, MSc

@djc795 · X

@cardioPCImom @Almanfi_Cardio Here's the link to the primary publication of the ACTIVATION trial results... https://t.co/hKuiRVzEbz

Jul 27, 2023 · 2 likes · 18,933 followers View post →

reynaldogomez6

@reynaldogomez61 · X

RT @AlfredoERodrig2: PCI or conservative treatment during TAVI: Results of ACTIVATION shouldn't be a surprise; it's similar to other trial…

Jul 6, 2023 · 1 share · 204 followers View post →

Alfredo E Rodriguez

@AlfredoERodrig2 · X

PCI or conservative treatment during TAVI: Results of ACTIVATION shouldn't be a surprise; it's similar to other trials of PCI in SA. Conservative may be better than an aggressive strategy unless critical lesions involve major vessels. https://t.co/AwK9EQl9hd

Jul 6, 2023 · 4 likes · 1 share · 293 followers View post →

Josh Wilcox

@jdrwilcox · X

@Miguel_MAntunes @Almanfi_Cardio @adnanalkhouli https://t.co/Jc1n9QH2Oe

Mar 15, 2023 · 3 likes · 1,137 followers View post →

Josh Wilcox

@jdrwilcox · X

RT @IamSpurs: @SarahFairley7 See ACTIVATION trial too. https://t.co/j4H68HArb9 https://t.co/ZzX21WS5B2

May 2, 2022 · 1 share · 1,137 followers View post →

Aung Myat MD

@IamSpurs · X

@SarahFairley7 See ACTIVATION trial too. https://t.co/j4H68HArb9 https://t.co/ZzX21WS5B2

May 2, 2022 · 5 likes · 1 share · 3,462 followers View post →

Anjan Gupta

@ACSCardiology · X

Observed rates of death and rehospitalization at 1 year were similar between PCI and no PCI prior to TAVR; however, the noninferiority margin was not met, and PCI resulted in a higher incidence of bleeding. @jaccjournals https://t.co/XpQH1LUogL

Oct 24, 2021 · 1 like · 432 followers View post →

Amr S. Gamal, MBBCh, MRCP, MSc, PhD, FESC

@AmrGama00480068 · X

ACTIVATION (percutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION): a randomized clinical trial via @PCRonline https://t.co/gOe8YsDzSa @andrewwiper @RobertsHesketh

Oct 23, 2021 · 1 like · 848 followers View post →

Keith Andrew Chan, MD

@keithachanmd · X

ACTIVATION TRIAL ⚠️PCI vs No PCI prior to TAVR in pts with sig CAD

Oct 10, 2021 · 2 likes · 538 followers View post →

Peter Pollak, MD

@DrPeterPollak · X

At long last. #ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION): A Randomized Clinical Trial https://t.co/Rdf8BOVoq9

Sep 23, 2021 · 1 like · 786 followers View post →

William Suh, MD

@willsuh76 · X

RT @nazliokumus: From @jaccjournals https://t.co/zzZEfgIBMl PCI vs no PCI before TAVR #CardioTwitter #jacc #TAVR https://t.co/Sl5mWBysj2

Sep 23, 2021 · 2 shares · 15,612 followers View post →

TAVR Bot

@TAVRBot · X

RT @nazliokumus: From @jaccjournals https://t.co/zzZEfgIBMl PCI vs no PCI before TAVR #CardioTwitter #jacc #TAVR https://t.co/Sl5mWBysj2

Sep 23, 2021 · 2 shares · 2,908 followers View post →

Nazli Okumus

@nazliokumus · X

From @jaccjournals https://t.co/zzZEfgIBMl PCI vs no PCI before TAVR #CardioTwitter #jacc #TAVR https://t.co/Sl5mWBysj2

Sep 22, 2021 · 3 likes · 2 shares · 1,028 followers View post →

Kent, So

@kentso987 · X