PubHawk
Aging Cell October 2021 PMID 34587364

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence.

Li-Bin Gao, Ya-Hong Wang, Zhi-Hua Liu, Yu Sun, Peng Cai, Qing Jing

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Mentions

14
Peak: 6 in Sep 2021
across 4 sources since Sep 2021

Extended reach

54,164
potential audience

Total likes

8

Video views

417

Mentions per month

Sep 2021 – Nov 2022

Where it's discussed

  • X / Twitter9 posts
  • News2 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions highlight excitement about the potential of activating NRF2 as a innovative strategy, with phrases like 'novel therapeutic approach' and 'counteract cellular senescence.' The tone reflects a recognition of the study's importance, and the emphasis on mechanistic insights indicates a keen interest in understanding the broader implications for aging and disease prevention.

AgreementStrong agreement

Most posts strongly agree on the potential of NRF2 activation as a promising therapeutic approach for combating cellular senescence.

InterestHigh interest

Discussions demonstrate high interest, with posts emphasizing the significance of the molecular findings and their potential implications.

EngagementModerate engagement

While some posts briefly mention the study, others delve into mechanisms and future applications, showing a moderate level of engagement.

ImpactHigh impact

The majority believe this research could lead to impactful therapies addressing aging and related diseases.

Abstract in brief

  • The study identifies SR9009 as a small molecule that suppresses the senescence-associated secretory phenotype (SASP), which is linked to inflammation and chronic disease.
  • SR9009 works by activating the NRF2 pathway, reducing reactive oxygen species (ROS) levels and inhibiting DNA damage response, thereby preventing cellular senescence in both cell models and mouse experiments.
  • These findings suggest that activating NRF2 with compounds like SR9009 could be a new therapeutic approach to control or prevent diseases related to cellular aging and senescence.
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Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence https://t.co/NeawsNgBmV https://t.co/DMqtdecZtK

Sep 30, 2021 · 2 likes · 41,853 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/TpOaNXiks2

Oct 2, 2021 · 1 share · 3,149 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/TpOaNXiks2

Sep 30, 2021 · 1 share · 3,149 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/TpOaNXiks2

Sep 30, 2021 · 1 share · 3,149 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence https://t.co/d8ZeovPybt To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAQQ7D https://t.co/Sw8Uba3Nwd

Sep 29, 2021 · 883 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence.: https://t.co/zuE2IV1z9h

Sep 30, 2021 · 725 followers View post →

All mentions

ivLab
@vinnikovLAB · X

Nov 21, 2022 · 59 followers View post →
Orlando_uy
@Orlando_uy · X

Activation of NRF2 may be a novel therapeutic strategy for preventing cellular senescence. https://t.co/ShEsEccZcL

Oct 15, 2021 · 694 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/TpOaNXiks2

Oct 2, 2021 · 1 share · 3,149 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/TpOaNXiks2

Sep 30, 2021 · 1 share · 3,149 followers View post →
Nutriop Longevity
@nutriop · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular #senescence https://t.co/HbHxRDfB59 https://t.co/CtyaLOTWcv

Sep 30, 2021 · 80 followers View post →
Agingdoc
@agingdoc1 · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence https://t.co/NeawsNgBmV https://t.co/DMqtdecZtK

Sep 30, 2021 · 2 likes · 41,853 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/TpOaNXiks2

Sep 30, 2021 · 1 share · 3,149 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence.: https://t.co/zuE2IV1z9h

Sep 30, 2021 · 725 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence https://t.co/d8ZeovPybt To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAQQ7D https://t.co/Sw8Uba3Nwd

Sep 29, 2021 · 883 followers View post →