October 2021 PMID 34602607

Déjà-vu? Neural and behavioural effects of the 5-HT receptor agonist, prucalopride, in a hippocampal-dependent memory task.

Angharad N de Cates, Lucy C Wright, Marieke A G Martens, Daisy Gibson, Cagdas Türkmen, Nicola Filippini, Philip J Cowen, Catherine J Harmer, Susannah E Murphy

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Mentions

46
Peak: 21 in Oct 2021
across 5 sources since Oct 2021

Extended reach

444,326
potential audience

Total likes

7,936

Video views

251,516

Mentions per month

Oct 2021 – Mar 2025

Where it's discussed

  • X / Twitter20 posts
  • News15 articles
  • Blogs5 articles
  • Reddit4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The posts demonstrate curiosity about the research, using language like 'promising drug' and references to improved memory, while also mentioning the unexpected role of a constipation medication, illustrating engagement and interest through examples and tone that emphasize novelty and potential clinical impact.

AgreementModerate agreement

Many posts seem intrigued and supportive, highlighting the potential for a constipation medication to improve memory, indicating general agreement with the research's significance.

InterestModerate interest

The posts express curiosity about the connection between a common drug and cognitive enhancement, showing moderate interest.

EngagementModerate engagement

Discussions include mentions of specific effects like increased memory and neural activity, suggesting active engagement with the scientific findings.

ImpactModerate impact

The posts imply a noteworthy potential for the research to influence treatments for mental health, indicating a moderate but meaningful impact.

Abstract in brief

  • The study investigated how the 5HT receptor partial agonist prucalopride affects memory and brain activity in healthy humans, finding that short-term treatment improved recall of images and neural hippocampal activity.
  • Results showed that after six days of prucalopride, participants performed better in distinguishing familiar from new images, with increased activity in the hippocampus and right angular gyrus observed through fMRI.
  • The findings suggest that activating the 5HT receptor could enhance cognitive functions and may be a promising approach for treating cognitive impairments in psychiatric disorders.]

Top posts

Most liked on X and Bluesky
SciShow
@SciShow · X

We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation! https://t.co/MW3cNAJwpq https://t.co/te3tR1DE4T

Oct 8, 2021 · 22 likes · 5 shares · 115,477 followers View post →
Oxford Psychiatry
@OxPsychiatry · X

A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharaddecates @UniofOxford explained from 2.30 mins - Watch now @OxfordMedSci @OxNeuro @OxHealthBRC @Mental_Elf @OxfordSparks @OxExpPsy @NDCNOxford @OxfordWIN

Oct 12, 2021 · 6 likes · 4 shares · 22,114 followers View post →
Oxford Psychiatry
@OxPsychiatry · X

Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task https://t.co/NVkD5VmqIs

Oct 4, 2021 · 2 likes · 22,098 followers View post →
Europe PMC articles
@EuropePMC · X

New from #OfficialNIHR https://t.co/ylhbwbXVWX Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task.

Oct 8, 2021 · 1 like · 1,554 followers View post →
OxfordSparks
@OxfordSparks · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 11,548 followers View post →
Oxford Impacts
@OxEngage · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 5,377 followers View post →

All mentions

#TheSpiderHunter - Black History Is Important!
@Arthur59611540 · X

Tonight's Health Feature A Constipation Drug Could Improve Memory | SciShow News https://t.co/TVbhBleXVA via @YouTube

Oct 14, 2021 · 4,116 followers View post →
Oxford Impacts
@OxEngage · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 5,377 followers View post →
DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 1,471 followers View post →
Oxford PERL Lab
@OxfordPERL · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 1,253 followers View post →
OxfordSparks
@OxfordSparks · X

RT @OxPsychiatry: A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharadd…

Oct 12, 2021 · 4 shares · 11,548 followers View post →
Oxford Psychiatry
@OxPsychiatry · X

A Constipation Drug Could Improve Memory | SciShow News https://t.co/fYOi1chUb6 via @YouTube New research from @angharaddecates @UniofOxford explained from 2.30 mins - Watch now @OxfordMedSci @OxNeuro @OxHealthBRC @Mental_Elf @OxfordSparks @OxExpPsy @NDCNOxford @OxfordWIN

Oct 12, 2021 · 6 likes · 4 shares · 22,114 followers View post →
Crystal
@crysthecat · X

RT @SciShow: We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation!…

Oct 11, 2021 · 5 shares · 113 followers View post →
Codexswitch
@Codexswitch1 · X

https://t.co/eNxXnXmuz0 You're memory will get almost 15% better, but you will be unable to stop filling your pants. I know the lot of you will be lining up asap for this, ya stinky animals <3

Oct 11, 2021 · 253 followers View post →
SCREENCHART!
@Screenchart · X

RT @SciShow: We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation!…

Oct 9, 2021 · 5 shares · 300 followers View post →
Gohsuke Takama
@gohsuket · X

|・ω・`)フムフム "A Constipation Drug Could Improve Memory | SciShow News" on YouTube - https://t.co/icoyW6Ohwz

Oct 9, 2021 · 2,992 followers View post →
Simon Tombs
@tombssimon · X

RT @SciShow: We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation!…

Oct 9, 2021 · 5 shares · 212 followers View post →
Europe PMC articles
@EuropePMC · X

New from #OfficialNIHR https://t.co/ylhbwbXVWX Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task.

Oct 8, 2021 · 1 like · 1,554 followers View post →
Creative Brain 4 Life
@CreativeBrain77 · X

https://t.co/8msncVOnCP https://t.co/1hOCwOdXPG This episode is sponsored by Endel, an app that creates personalised soundscapes that will help you focus, loosen up and sleep.The primary

Oct 8, 2021 · 1 followers View post →
Kitty
@kittybravofan · X

How a Constipation Drug Might Help Mental Illness | SciShow News https://t.co/we9lh21GGV via @YouTube

Oct 8, 2021 · 719 followers View post →
Johannes Lüke
@JohannesSLueke · X

New video by SciShow: How a Constipation Drug Might Help Mental Illness | SciShow News https://t.co/x4I60FbIYZ

Oct 8, 2021 · 83 followers View post →
e-csce
@e_csce · X

How a Constipation Drug Might Help Mental Illness | SciShow News @ https://t.co/l8JrglBkxZ https://t.co/Otvo6p4bjz

Oct 8, 2021 · 117 followers View post →
William Wallace
@bill14051 · X

RT @SciShow: We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation!…

Oct 8, 2021 · 5 shares · 334 followers View post →
SciShow
@SciShow · X

We've found a promising drug for treating mental illness, funny thing is, it was originally designed to relieve constipation! https://t.co/MW3cNAJwpq https://t.co/te3tR1DE4T

Oct 8, 2021 · 22 likes · 5 shares · 115,477 followers View post →
Paul McCullough
@ThePostsynaptic · X

Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task https://t.co/axdyqUpILE https://t.co/1xmEGTRw14

Oct 4, 2021 · 2,589 followers View post →
Oxford Psychiatry
@OxPsychiatry · X

Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task https://t.co/NVkD5VmqIs

Oct 4, 2021 · 2 likes · 22,098 followers View post →