Front Immunol October 2021 PMID 34616392

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.

Yannick D Muller, Leonardo M R Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin K Leung, Nikolaos Skartsis, Anupurna M Kaul, Arend Mulder, Frans H J Claas, James A Wells, Jeffrey A Bluestone

Mentions

71
Peak: 23 in Sep 2021
across 3 sources since Aug 2021

Extended reach

309,410
potential audience

Total likes

202

Video views

4,302

Mentions per month

Aug 2021 – Jan 2024

Where it's discussed

  • X / Twitter60 posts
  • News9 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions demonstrate strong support and curiosity, with phrases like 'hope to see this work in human trials' and 'created regulatory T cells using gene editing,' emphasizing excitement and recognition of the research’s significance. The tone is positive and forward-looking, showcasing the perceived high impact of engineering T cells for transplant tolerance.

AgreementModerate agreement

Most discussions express support or curiosity about the research, highlighting its promising potential.

InterestHigh interest

Posts show high interest, with users engaging in questions and appreciation for the advancements.

EngagementModerate engagement

Several comments include detailed descriptions, acknowledgments, and references, indicating active participation.

ImpactHigh impact

The frequent mention of clinical implications, gene editing techniques, and potential for transplantation highlight the significant impact of this research.

Top posts

Most liked on X and Bluesky
Leonardo Ferreira
@enhancerleo · X

We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR that recognizes HLA-A2 (class I)! They prevent #GraftvsHostDisease & traffic to #transplanted A2+ #pancreatic #islets! #thefutureishere https://t.co/dEePITSfD2 https://t.co/0J22xXhgg5

Sep 20, 2021 · 72 likes · 17 shares · 3,072 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/waWTEqYZCG #biorxiv_immuno

Aug 17, 2021 · 14 likes · 2 shares · 10,627 followers View post →
bioRxiv
@biorxivpreprint · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/497mEYxKYs #bioRxiv

Aug 17, 2021 · 11 likes · 3 shares · 137,019 followers View post →
Leonardo Ferreira
@enhancerleo · X

Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as part of @BioCentury’s roundup of #translational #news! #immunologymatters https://t.co/AFfPZOflDB https://t.co/8y4G2Mpczy https://t.co/TyKFUADiCe

Oct 6, 2021 · 10 likes · 6 shares · 3,072 followers View post →
Frontiers - Immunology
@FrontImmunol · X

New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance: Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting… https://t.co/GrbpVJM8Dj #immunology

Sep 20, 2021 · 9 likes · 4 shares · 33,767 followers View post →
Leonardo Ferreira
@enhancerleo · X

What are the implications for #aging & #longevity of our work engineering #Tregs for #transplantation #tolerance? Thank you to Danielle Davis for creating this video, with the initiative and support of @DayOneVC! #immunologymatters https://t.co/KmYLVlM5QY https://t.co/8y4G2Mpczy https://t.co/C1s1lS9fVY

Oct 12, 2021 · 8 likes · 2 shares · 3,072 followers View post →

All mentions

Ferreira Lab
@leoferreiralab · X

RT @Madam_Mito: https://t.co/09oOR9o4Yg Interesting talk. @enhancerleo #Aging

Jan 21, 2024 · 2 shares · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

RT @Madam_Mito: https://t.co/09oOR9o4Yg Interesting talk. @enhancerleo #Aging

Jan 21, 2024 · 2 shares · 3,072 followers View post →
Madam Mitochondria
@Madam_Mito · X

https://t.co/09oOR9o4Yg Interesting talk. @enhancerleo #Aging

Jan 20, 2024 · 6 likes · 2 shares · 10,236 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @enhancerleo: Unfreeze your science! Thank you @CRYOPDP and Guilherme Cardoso for the opportunity of being interviewed for the inaugural…

Sep 16, 2023 · 1 share · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

Unfreeze your science! Thank you @CRYOPDP and Guilherme Cardoso for the opportunity of being interviewed for the inaugural episode of your new podcast. #immunologymatters #changingwhatspossible https://t.co/3X1tLSc9qp https://t.co/CeIX0uo4hE

Sep 16, 2023 · 5 likes · 1 share · 3,072 followers View post →
Leonardo Ferreira
@enhancerleo · X

In 2021, I co-authored a study genetically engineering immunosuppressive human regulatory T cells (CAR Tregs) that traffic to transplanted human pancreatic islets. https://t.co/6e2U348J6S

Jun 15, 2023 · 2 likes · 3,072 followers View post →
Yannick Daniel Muller
@YannickDaMuller · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Nov 28, 2021 · 6 shares · 62 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @HIRN_CC: Highlighting #HIRN supported manuscript: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cel…

Nov 15, 2021 · 3 shares · 144 followers View post →
UCSF Transplant
@UCSFTransplant · X

RT @HIRN_CC: Highlighting #HIRN supported manuscript: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cel…

Nov 15, 2021 · 3 shares · 1,668 followers View post →
Leonardo Ferreira
@enhancerleo · X

RT @HIRN_CC: Highlighting #HIRN supported manuscript: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cel…

Nov 15, 2021 · 3 shares · 3,072 followers View post →
HIRN
@HIRN_CC · X

Highlighting #HIRN supported manuscript: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance in @FrontImmunol https://t.co/gpWFNwmTtW @enhancerleo @leoferreiralab @kickassscience1 @QizhiTang #HIRNfundedResearch

Nov 12, 2021 · 6 likes · 3 shares · 1,392 followers View post →
ImmunotherapyPapers
@Immunotx_papers · X

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance https://t.co/zGfOWqyIlo

Oct 17, 2021 · 247 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @enhancerleo: Células regulatórias T reeducadas utilizando edição genética hoje no Público! Pela inigualável @AndreaCF @Publico. #immuno…

Oct 13, 2021 · 1 share · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

Células regulatórias T reeducadas utilizando edição genética hoje no Público! Pela inigualável @AndreaCF @Publico. #immunologymatters #CARTregs https://t.co/W3XAGEosab https://t.co/8y4G2Mpczy https://t.co/MrzQxXBohN

Oct 13, 2021 · 6 likes · 1 share · 3,072 followers View post →
UCSF Transplant
@UCSFTransplant · X

RT @enhancerleo: What are the implications for #aging & #longevity of our work engineering #Tregs for #transplantation #tolerance? Thank yo…

Oct 12, 2021 · 2 shares · 1,668 followers View post →
UCSF Transplant
@UCSFTransplant · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Oct 12, 2021 · 6 shares · 1,668 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @enhancerleo: What are the implications for #aging & #longevity of our work engineering #Tregs for #transplantation #tolerance? Thank yo…

Oct 12, 2021 · 2 shares · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

What are the implications for #aging & #longevity of our work engineering #Tregs for #transplantation #tolerance? Thank you to Danielle Davis for creating this video, with the initiative and support of @DayOneVC! #immunologymatters https://t.co/KmYLVlM5QY https://t.co/8y4G2Mpczy https://t.co/C1s1lS9fVY

Oct 12, 2021 · 8 likes · 2 shares · 3,072 followers View post →
Albeena Nisar
@AlbeenaDr · X

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.#Tregcelltherapies @DrGauravNarula @CTCTC_tmc https://t.co/95Bzgo3gwB

Oct 9, 2021 · 631 followers View post →
Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx
@CARTTherapy · X

Precision Engineering of an Anti-HLA-A2 CAR in Regulatory T Cells for Transplant Immune Tolerance https://t.co/1eMJoLgY6u #CART #bmtsm #CARTcell #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy @ASTCT @FrontImmunol Hope to see this work nicely in human trials!!

Oct 7, 2021 · 5 likes · 4,457 followers View post →
CRISPRpapers
@CRISPR_papers · X

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance https://t.co/vLwrAGDq0U

Oct 7, 2021 · 3,894 followers View post →
jaimevquiroga
@jaimevquiroga · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Oct 7, 2021 · 6 shares · 41 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Oct 6, 2021 · 6 shares · 144 followers View post →
Boaty McBoatface
@srqstockpicker · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Oct 6, 2021 · 6 shares · 4,578 followers View post →
BioCentury
@BioCentury · X

RT @enhancerleo: Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as p…

Oct 6, 2021 · 6 shares · 16,376 followers View post →
Leonardo Ferreira
@enhancerleo · X

Our #TCR deficient HLA-A2 #specific #CAR #Tregs that prevent #graftvshost #disease in #humanized #mice were featured as part of @BioCentury’s roundup of #translational #news! #immunologymatters https://t.co/AFfPZOflDB https://t.co/8y4G2Mpczy https://t.co/TyKFUADiCe

Oct 6, 2021 · 10 likes · 6 shares · 3,072 followers View post →
Human Immunology News
@humanimmunenews · X

Scientists demonstrate that genome-engineered mono-antigen-specific A2-CAR #Tregs localize to HLA-A2-expressing grafts. Read the full article here: https://t.co/Q2Nher2gPt https://t.co/VMytJfAhNZ

Sep 22, 2021 · 5 likes · 1 share · 14,426 followers View post →
Andrea
@reand71 · X

RT @FrontImmunol: New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immu…

Sep 22, 2021 · 4 shares · 8 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @FrontImmunol: New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immu…

Sep 21, 2021 · 4 shares · 144 followers View post →
C. 'Harris' Floudas
@chfloudas · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 773 followers View post →
UCSF Surgery
@UCSFSurgery · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 7,023 followers View post →
Roberto Castro Gutierrez
@RobertoCG96 · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 350 followers View post →
Vladislav Sergeev
@DrVladSergeev · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 285 followers View post →
Hugo Alves Figueiredo
@FigueiredoHug · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 87 followers View post →
Monika Yadav, PhD
@Yadavmonika15 · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 82 followers View post →
Thomas Tan, Ph.D.
@SENGLAITAN · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 10,237 followers View post →
Investor Businessman
@InvestorBusine1 · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 534 followers View post →
Guillaume Darrasse-Jeze
@G_Darrasse_Jeze · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 238 followers View post →
jaimevquiroga
@jaimevquiroga · X

RT @FrontImmunol: New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immu…

Sep 21, 2021 · 4 shares · 41 followers View post →
Himanshu MTech, PhD
@drmacrophage1 · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 21, 2021 · 17 shares · 42 followers View post →
Eve Beavers
@espacetimeCO · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 20, 2021 · 17 shares · 897 followers View post →
Martin Correa
@martinrafco · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 20, 2021 · 17 shares · 232 followers View post →
Diabetes Center at UCSF
@AtUcsf · X

From our newest core faculty member Qizhi Tang @QizhiTang https://t.co/NRW1cW3FbF

Sep 20, 2021 · 7 likes · 489 followers View post →
Banaba Joana
@BanabaJoana · X

RT @FrontImmunol: New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immu…

Sep 20, 2021 · 4 shares · 63 followers View post →
Frontiers - Immunology
@FrontImmunol · X

New Research: Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance: Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting… https://t.co/GrbpVJM8Dj #immunology

Sep 20, 2021 · 9 likes · 4 shares · 33,767 followers View post →
Ramsés CR
@jchavez_rios · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 20, 2021 · 17 shares · 269 followers View post →
UCSF Transplant
@UCSFTransplant · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 20, 2021 · 17 shares · 1,668 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @enhancerleo: We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR t…

Sep 20, 2021 · 17 shares · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

We created #human #regulatory #Tcells (#Tregs) where their (class II-restricted) #TCR was replaced via #CRISPR w/ a #CAR that recognizes HLA-A2 (class I)! They prevent #GraftvsHostDisease & traffic to #transplanted A2+ #pancreatic #islets! #thefutureishere https://t.co/dEePITSfD2 https://t.co/0J22xXhgg5

Sep 20, 2021 · 72 likes · 17 shares · 3,072 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @3DiMMUNE: can CAR-Treg function normally? This preprint showed they could survive for 2 weeks. Precision engineering of an anti-HL…

Aug 19, 2021 · 1 share · 1,005 followers View post →
Michelle Dion
@michellezdion · X

RT @biorxivpreprint: Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune toleranc…

Aug 19, 2021 · 3 shares · 371 followers View post →
David Usharauli
@3DiMMUNE · X

can CAR-Treg function normally? This preprint showed they could survive for 2 weeks. Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/jOroaIChrS

Aug 19, 2021 · 1 share · 2,721 followers View post →
bxv_imm
@bxv_imm · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/B3vhBH6vsU

Aug 17, 2021 · 441 followers View post →
UCSF Transplant
@UCSFTransplant · X

RT @biorxivpreprint: Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune toleranc…

Aug 17, 2021 · 3 shares · 1,668 followers View post →
Ferreira Lab
@leoferreiralab · X

RT @biorxiv_immuno: Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance…

Aug 17, 2021 · 2 shares · 144 followers View post →
Leonardo Ferreira
@enhancerleo · X

RT @biorxiv_immuno: Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance…

Aug 17, 2021 · 2 shares · 3,072 followers View post →
Leonardo Ferreira
@enhancerleo · X

RT @biorxivpreprint: Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune toleranc…

Aug 17, 2021 · 3 shares · 3,072 followers View post →
Engineering Papers
@eng_papers · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/BYkki6er6D

Aug 17, 2021 · 45 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/waWTEqYZCG #biorxiv_immuno

Aug 17, 2021 · 14 likes · 2 shares · 10,627 followers View post →
bioRxiv
@biorxivpreprint · X

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance https://t.co/497mEYxKYs #bioRxiv

Aug 17, 2021 · 11 likes · 3 shares · 137,019 followers View post →