J Eur Acad Dermatol Venereol February 2022 PMID 34634163

Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial.

B M Piraccini, U Blume-Peytavi, F Scarci, J M Jansat, M Falqués, R Otero, M L Tamarit, J Galván, V Tebbs, E Massana

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Mentions

75
Peak: 21 in Jan 2022
across 4 sources since Oct 2021

Extended reach

209,294
potential audience

Total likes

1,030

Video views

49,709

Mentions per month

Oct 2021 – Aug 2025

Where it's discussed

  • X / Twitter55 posts
  • News15 articles
  • YouTube3 videos
  • Reddit2 posts

AI synopsis

What people are saying

The overall digital discussions reflect a positive reception, highlighting the study’s promising results with phrases like 'effective' and 'less side effects,' and consider topical finasteride a valuable alternative to oral medications; tone and words emphasize its potential to impact treatments for male hair loss.

AgreementModerate agreement

Most discussions support the article’s findings, noting the efficacy and safety of topical finasteride as a promising treatment option.

InterestModerate interest

Posts show moderate interest, mentioning the study’s details, such as reduced systemic effects and comparable efficacy to oral treatments.

EngagementModerate engagement

Many are engaging by sharing summaries, discussing side effects, or mentioning related trials, indicating a decent level of involvement.

ImpactModerate impact

The discussions suggest the research could influence treatment approaches and spark further interest or development in topical finasteride.

Abstract in brief

  • A phase III clinical trial showed that topical finasteride is effective and safe for treating male androgenetic alopecia, with better hair growth results than placebo and similar outcomes to oral finasteride.
  • The study found that topical finasteride led to fewer systemic side effects and lower blood levels of the drug and DHT compared to oral treatment, suggesting reduced risk of sexual adverse effects.
  • Overall, the research indicates that topical finasteride could be a promising alternative to oral medication, offering effective hair growth with a better safety profile.

Top posts

Most liked on X and Bluesky
Julián Conejo-Mir
@julianconejomir · X

Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero menos que finasteride oral 1 mg. https://t.co/xxslewRrbC

Jan 12, 2022 · 50 likes · 17 shares · 12,664 followers View post →
JEADV Clinical Practice
@TheJEACP · X

Read this study by Piraccini et al. published in the #JEADV concerning the efficacy and safety of topical finasteride spray solution for male #androgenetic #alopecia.>>https://t.co/1VKE2svAal https://t.co/17hGai9Xos

Jan 12, 2022 · 21 likes · 3 shares · 2,076 followers View post →
Victor Atallah
@vicatallah · X

Solución tópica en aerosol de finasterida para alopecia (calvicie) androgenética masculina parece ser más eficaz en tratamiento que placebo y puede tener eficacia similar a la oral, con menos efectos secundarios sistémicos, Estudio 458 hombres #VEA https://t.co/EQ7daui5cr

Jan 3, 2022 · 19 likes · 3 shares · 42,149 followers View post →
Kevin McElwee
@ResearchHair · X

Study where 323 patients were given a topical finasteride spray/lotion for #hairloss. At 24 weeks, hair density was significantly greater with topical finasteride than placebo (adjusted mean change 20.2 vs 6.7 hairs; p < 0.001). Not #openaccess https://t.co/o6ZzbejHAl

Oct 14, 2021 · 11 likes · 3 shares · 881 followers View post →
Nicølªs Kluger
@NicoKluger · X

Bonne nouvelle pour les chauves (enfin les récents, hein), le finasteride topique est en développement. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial https://t.co/Ok4DGTeXuy https://t.co/njBuZSOa4w

Mar 12, 2022 · 6 likes · 1 share · 5,599 followers View post →
Finasteride Watch
@FinasterideInfo · X

Evasive safety reporting in a pharma-sponsored clinical trial @AlmirallUS. Paper omits overall erectile function score in topical, oral and placebo groups. These should be reported first, with a statistical test. #finasteride #clinicaltrials #dermatology https://t.co/md9V7lxk96 https://t.co/yyq8983vf4

Feb 27, 2023 · 5 likes · 1 share · 816 followers View post →

All mentions

Dr. Farshid Etaee, MD
@MilanResearch · X

Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia! https://t.co/fz36StrMed

Apr 27, 2025 · 2 likes · 1 followers View post →
Weekesy
@Weekesy_jw · X

@Larryjamieson_ Furthermore, finasteride is currently undergoing clinical trials for pattern hair loss and the literature around its topical use suggests the rate of adverse effects is even lower than taken systemically with a similar efficacy. https://t.co/RySGf2GDBC

Jan 26, 2025 · 1 like · 57 followers View post →
Aris
@Lunaris2003 · X

@Drahmedghareeb https://t.co/6cCftHuM0O

Jan 9, 2025 · 258 followers View post →
Olivarius Humulhortus
@OlivariusH · X

@EwigerAugust @japanfrosch Link vergessen

Nov 16, 2024 · 2 likes · 235 followers View post →
ねこ先生@AGA治療エビデンス解説
@doctor_neco · X

RT @doctor_neco: フィナステリドの外用「#塗りフィナス」現る AGA飲み薬の代表格といえばフィナステリド #フィナステリド、には外用もあるぞ! 塗りフィナスの効果は? 結論、フィナステリド内服と同等の発毛効果

Nov 15, 2024 · 2 shares · 128 followers View post →
たっち@40代の毛根復活術
@TouchGrowsHair · X

RT @doctor_neco: フィナステリドの外用「#塗りフィナス」現る AGA飲み薬の代表格といえばフィナステリド #フィナステリド、には外用もあるぞ! 塗りフィナスの効果は? 結論、フィナステリド内服と同等の発毛効果

Nov 12, 2024 · 2 shares · 1,002 followers View post →
ねこ先生@AGA治療エビデンス解説
@doctor_neco · X

フィナステリドの外用「#塗りフィナス」現る AGA飲み薬の代表格といえばフィナステリド #フィナステリド、には外用もあるぞ! 塗りフィナスの効果は? 結論、フィナステリド内服と同等の発毛効果

Nov 9, 2024 · 2 likes · 2 shares · 128 followers View post →
Scrimblo Bimblo⚓️
@ScrimbloB · X

@patapackala @LinkofSunshine If you’re willing to try you can decrease the dose or use a topical formulation. https://t.co/CTrJsDkjZE

Jun 19, 2024 · 5 likes · 273 followers View post →
Nico
@Nicolas93793927 · X

@lethargiclich @camipple https://t.co/CYg85gPjBS

May 3, 2024 · 139 followers View post →
David Barnard
@drbarnard · X

@elwatto Um… I’ve actually got both going on, the balding has just been slower. While I’m fine wearing the grey hair as a badge of honor, I started fighting back on the balding: https://t.co/6yV5EKljfm

Apr 12, 2024 · 14,931 followers View post →
frederickhenry
@3littlepatience · X

@antidoc32 @RodneyAllebach https://t.co/LctAL0M29a

Mar 6, 2024 · 74 followers View post →
Finasteride Watch
@FinasterideInfo · X

This trial of topical finasteride used the IIEF instrument (assessing erectile function), but did not report the scores, and did not describe how those scores were used in determining adverse events. Efficacy & safety of topical finasteride spray... https://t.co/md9V7lxk96

Oct 6, 2023 · 816 followers View post →
AFCLee_
@AFCLee_ · X

@emekaCkA @Chrinkster https://t.co/sCokaEgRvh. It’s still significant albeit less than oral preps

Sep 10, 2023 · 1,531 followers View post →
Lucas Koi
@KoiLucas · X

@Serotonin2arec @C_Angermayer @hubermanlab @slime_jpeg @gainzy222 Really well. Also, please never take oral minoxidil. It's a pretty dangerous drug taken orally. https://t.co/U0V7ilXSAl

Jul 17, 2023 · 34 followers View post →
Informed Consent Matters
@stopharmingus · X

RT @FinasterideInfo: Evasive safety reporting in a pharma-sponsored clinical trial @AlmirallUS. Paper omits overall erectile function score…

Feb 28, 2023 · 1 share · 1,819 followers View post →
HELP PARENTS STOP SIBLING ABUSE
@Hope4Siblings · X

RT @FinasterideInfo: Even with 1/100 level of finasteride in serum from topical finasteride vs. oral, there was still 34.5% suppression of…

Feb 27, 2023 · 3 shares · 8,060 followers View post →
Aide aux Victimes du Finasteride
@AVFIN_asso · X

RT @FinasterideInfo: Even with 1/100 level of finasteride in serum from topical finasteride vs. oral, there was still 34.5% suppression of…

Feb 27, 2023 · 3 shares · 90 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

RT @FinasterideInfo: Even with 1/100 level of finasteride in serum from topical finasteride vs. oral, there was still 34.5% suppression of…

Feb 27, 2023 · 3 shares · 6,544 followers View post →
Finasteride Watch
@FinasterideInfo · X

Evasive safety reporting in a pharma-sponsored clinical trial @AlmirallUS. Paper omits overall erectile function score in topical, oral and placebo groups. These should be reported first, with a statistical test. #finasteride #clinicaltrials #dermatology https://t.co/md9V7lxk96 https://t.co/yyq8983vf4

Feb 27, 2023 · 5 likes · 1 share · 816 followers View post →
Finasteride Watch
@FinasterideInfo · X

Even with 1/100 level of finasteride in serum from topical finasteride vs. oral, there was still 34.5% suppression of serum DHT. New pharma tactics: Topical. Liposomal delivery. Plant-based. All still lower DHT, with attendant risks. https://t.co/md9V7lxk96 h/t @PFSFoundation

Feb 27, 2023 · 3 likes · 3 shares · 816 followers View post →
たつろう@髪が生える
@Oppp7iQ · X

詳しく知りたい方用 (2021.イタリア、ドイツ、スペイン、英国の共同研究) https://t.co/8d8Ez4W9gI

Feb 12, 2023 · 1 like · 1,834 followers View post →
Lukas Tanasiuk
@igobylukas · X

@DrCamRx @awilkinson Sorry, I had my %'s off a bit, hadn't read through this in over 6 months, but here you go! https://t.co/Xjl7jxhlKI

Dec 31, 2022 · 1,663 followers View post →
Patriot Dad 6947
@Dad2022Patriot · X

@adrusi @hyperdiscogirl @anonymiserly @Damask_Holdings I thought the same thing… there is a study with topical finasteride though that shows efficacy. https://t.co/4dYldzoLrh

Nov 7, 2022 · 3 likes · 347 followers View post →
Quthizen
@quthizen · X

RT @First64884394: @quthizen @AbdullahAlogaiy الفيناسترايد علاج ممتاز يمنع تحويل التستسترون الى الشكل الاقوى وهو DHT وهذا السبب في تساقط ال…

Sep 9, 2022 · 1 share · 4 followers View post →
Fares
@usual_unknown · X

@quthizen @AbdullahAlogaiy الفيناسترايد علاج ممتاز يمنع تحويل التستسترون الى الشكل الاقوى وهو DHT وهذا السبب في تساقط الشعر والصلع ، لا ادري صراحة لماذا لايتواجد بشكل موضعي رغم ان الدراسات تؤكد انه فعال جدا وآمن https://t.co/AgnrvtHhDZ

Sep 9, 2022 · 1 like · 1 share · 349 followers View post →
Dr Yusef Smith
@PropaneFitness · X

@HallionWild Less systemic T effect than oral finasteride but still drops it. Any symptoms from it? https://t.co/CrTECZnsE6

Jul 6, 2022 · 1 like · 15,164 followers View post →
DreVir
@viraust · X

RT @NicoKluger: Bonne nouvelle pour les chauves (enfin les récents, hein), le finasteride topique est en développement. Efficacy and safe…

Mar 12, 2022 · 1 share · 1,017 followers View post →
Nicølªs Kluger
@NicoKluger · X

Bonne nouvelle pour les chauves (enfin les récents, hein), le finasteride topique est en développement. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial https://t.co/Ok4DGTeXuy https://t.co/njBuZSOa4w

Mar 12, 2022 · 6 likes · 1 share · 5,599 followers View post →
Isa28
@mexiflyrider · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 14, 2022 · 17 shares · 148 followers View post →
Mireia
@MireDoc · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 1,005 followers View post →
M. Silveira
@manolosilveira · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 1,394 followers View post →
Tina
@TinadeCR · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 13 followers View post →
Gsus
@gsus_miron · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 23 followers View post →
Jesús Rodríguez Gálvez
@jerodgal · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 100 followers View post →
Javier Carrera
@Javier_CarreraH · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 1,826 followers View post →
Luis Capitán Morales
@LuisCapitnMora1 · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 116 followers View post →
Lluís Arcalà
@lluis1966 · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 2,051 followers View post →
David Saceda Corralo
@Desaze · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 13, 2022 · 17 shares · 5,562 followers View post →
M Pilar Pérez Bueno
@agruspar · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 12, 2022 · 17 shares · 2,848 followers View post →
IARETUSA
@IARETUSA · X

RT @julianconejomir: Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero me…

Jan 12, 2022 · 17 shares · 1,805 followers View post →
Julián Conejo-Mir
@julianconejomir · X

Finasteride tópico 0,25% en alopecia androgenetica masculina. ✅ Es efectivo ✅ Reduce la testosterona serica, pero menos que finasteride oral 1 mg. https://t.co/xxslewRrbC

Jan 12, 2022 · 50 likes · 17 shares · 12,664 followers View post →
David Saceda Corralo
@Desaze · X

RT @TheJEACP: Read this study by Piraccini et al. published in the #JEADV concerning the efficacy and safety of topical finasteride spray s…

Jan 12, 2022 · 3 shares · 5,562 followers View post →
Dr. Mara Mihai
@MaraMihai2 · X

RT @TheJEACP: Read this study by Piraccini et al. published in the #JEADV concerning the efficacy and safety of topical finasteride spray s…

Jan 12, 2022 · 3 shares · 890 followers View post →
JEADV
@TheJEADV · X

RT @TheJEACP: Read this study by Piraccini et al. published in the #JEADV concerning the efficacy and safety of topical finasteride spray s…

Jan 12, 2022 · 3 shares · 8,702 followers View post →
JEADV Clinical Practice
@TheJEACP · X

Read this study by Piraccini et al. published in the #JEADV concerning the efficacy and safety of topical finasteride spray solution for male #androgenetic #alopecia.>>https://t.co/1VKE2svAal https://t.co/17hGai9Xos

Jan 12, 2022 · 21 likes · 3 shares · 2,076 followers View post →
Huascar Casado PRM
@CasadoPrm · X

RT @vicatallah: Solución tópica en aerosol de finasterida para alopecia (calvicie) androgenética masculina parece ser más eficaz en tratami…

Jan 9, 2022 · 3 shares · 1,236 followers View post →
Ernesto Mejia F
@ermefe · X

RT @vicatallah: Solución tópica en aerosol de finasterida para alopecia (calvicie) androgenética masculina parece ser más eficaz en tratami…

Jan 3, 2022 · 3 shares · 119 followers View post →
Robinson Jiménez
@RobinJimenezF · X

RT @vicatallah: Solución tópica en aerosol de finasterida para alopecia (calvicie) androgenética masculina parece ser más eficaz en tratami…

Jan 3, 2022 · 3 shares · 85 followers View post →
Victor Atallah
@vicatallah · X

Solución tópica en aerosol de finasterida para alopecia (calvicie) androgenética masculina parece ser más eficaz en tratamiento que placebo y puede tener eficacia similar a la oral, con menos efectos secundarios sistémicos, Estudio 458 hombres #VEA https://t.co/EQ7daui5cr

Jan 3, 2022 · 19 likes · 3 shares · 42,149 followers View post →
Carlos De la Torre, MD. PhD.
@ctorrefraga · X

#alopecia #finasterida La finasterida tópica otra opción en alopecia Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial https://t.co/KmNkl2w2GG

Dec 7, 2021 · 573 followers View post →
Follicle Thought.com (Hair Growth Research)
@FollicleThought · X

@drdaviperezmeza https://t.co/rolddOku8c

Nov 8, 2021 · 1 like · 2,354 followers View post →
MARTA • trichologist/dermatology nurse
@clinihair · X

RT @ResearchHair: Study where 323 patients were given a topical finasteride spray/lotion for #hairloss. At 24 weeks, hair density was signi…

Oct 15, 2021 · 3 shares · 310 followers View post →
StephTs
@STurcios_Sa · X

RT @ResearchHair: Study where 323 patients were given a topical finasteride spray/lotion for #hairloss. At 24 weeks, hair density was signi…

Oct 14, 2021 · 3 shares · 260 followers View post →
Dark Brandon Rises
@iamgabbarson · X

RT @ResearchHair: Study where 323 patients were given a topical finasteride spray/lotion for #hairloss. At 24 weeks, hair density was signi…

Oct 14, 2021 · 3 shares · 544 followers View post →
Kevin McElwee
@ResearchHair · X

Study where 323 patients were given a topical finasteride spray/lotion for #hairloss. At 24 weeks, hair density was significantly greater with topical finasteride than placebo (adjusted mean change 20.2 vs 6.7 hairs; p < 0.001). Not #openaccess https://t.co/o6ZzbejHAl

Oct 14, 2021 · 11 likes · 3 shares · 881 followers View post →