Int J Mol Sci September 2021 PMID 34638902

Lipidomic and Proteomic Alterations Induced by Even and Odd Medium-Chain Fatty Acids on Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders.

Khaled I Alatibi, Stefan Tholen, Zeinab Wehbe, Judith Hagenbuchner, Daniela Karall, Michael J Ausserlechner, Oliver Schilling, Sarah C Grünert, Jerry Vockley, Sara Tucci

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Peak: 1 in Sep 2021

across 2 sources since Sep 2021

Extended reach

337,340

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336,785

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Sep 2021 – Aug 2024

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AI synopsis

What people are saying

Discussions highlight the potential of medium-chain fatty acids, especially C7, in restoring lipid functions, with words like 'protective' and 'important' conveying their optimism. Participants reference lipid remodeling and protein balance to underline the scientific relevance, demonstrating a blend of technical understanding and hope for clinical applications.

AgreementModerate agreement

Most discussions recognize the significance of the study, with some expressing optimism about its findings.

InterestHigh interest

The topic seems highly engaging for those interested in biochemistry or medical research, reflected in enthusiastic comments.

EngagementModerate engagement

Many comments delve into specific aspects like the protective role of C7, indicating moderate to deep engagement.

ImpactModerate impact

The discussions suggest the research could influence future treatments or understanding of lipid disorders, though this is somewhat aspirational.

Abstract in brief

The study investigates how medium-chain fatty acids (C7 and C8) affect fibroblasts from patients with long-chain fatty acid oxidation disorders, specifically VLCADD and LCHADD, using lipidomic and proteomic analysis.
Results show that these disorders cause significant changes in protein composition, but treatment with medium-chain fatty acids has only minor effects on these proteins; however, it does lead to remodeling of complex lipids.
Notably, C7 fatty acid appears to have a protective role by restoring lipid biosynthesis pathways and improving protein balance in cells affected by LCHADD.]

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IJMS, Vol. 22, Pages 10556: Lipidomic and Proteomic Alterations Induced by Even and Odd Medium-Chain Fatty Acids on Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders https://t.co/qQxB7iLNWJ

Sep 29, 2021 · 556 followers View post →