Nature October 2021 PMID 34646018

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis.

Shenbin Liu, Zhifu Wang, Yangshuai Su, Lu Qi, Wei Yang, Mingzhou Fu, Xianghong Jing, Yanqing Wang, Qiufu Ma

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Peak: 28 in Oct 2021

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AI synopsis

What people are saying

The discussions reflect a strong consensus on the scientific relevance, exemplified by phrases like 'neuro basis for acupuncture,' 'mechanism in a mouse model,' and references to detailed methodologies like RRIDs, indicating deep engagement and acknowledgment of the study's impact on legitimizing acupuncture through neuroanatomical evidence.

AgreementModerate agreement

Most discussions recognize the scientific basis and potential significance of the findings, with many expressing support and interest.

InterestHigh interest

Discussions show high curiosity about the neuroanatomical mechanisms and implications for acupuncture research.

EngagementHigh engagement

Posts delve into technical details, referencing specific pathways, methodologies, and corrections, indicating deep engagement.

ImpactHigh impact

Many discussions highlight the study’s importance for validating traditional methods scientifically, suggesting high impact on both research and clinical practice.

Abstract in brief

This study explores how electroacupuncture (ES) can activate specific parts of the nervous system, like the vagal adrenal axis, to reduce inflammation, and finds that the effectiveness depends on the body region targeted.
Researchers identified PROKR2-marked sensory neurons that innervate hindlimb tissues, which are essential for triggering this anti-inflammatory response, while similar neurons in abdominal tissue are not involved.
The findings show that stimulating nerve terminals at specific acupoints (like ST36) can selectively activate certain autonomic pathways, explaining the neuroanatomical basis for the body region specificity of electroacupuncture effects.]

Read the full abstract

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尸林の山田

@yamadatakaya · X

講義中で紹介された Article A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis（迷走神経-副腎系を駆動する鍼治療の神経解剖学的根拠）という論文の話には、リアタイ受講時も「ウオオ！」となったのをおぼえている。この図の一番下。 https://t.co/80T5VBa3sD https://t.co/XtVOdSY1wt

Jul 31, 2025 · 2 likes · 1,054 followers View post →

Ben Around

@Ben__Around · X

@ShohamTxID @StevenSalzberg1 @HarvardHealth https://t.co/OppmzTN1e4

May 10, 2025 · 1 like · 2,374 followers View post →

#Yuuki

@yuki_yuki0512 · X

RT @satoshimat28742: @denzaemon_kyoto はじめまして、コメント失礼します

Apr 4, 2025 · 3 shares · 328 followers View post →

どっぐす

@dogs_tw · X

RT @satoshimat28742: @denzaemon_kyoto はじめまして、コメント失礼します

Apr 3, 2025 · 3 shares · 1,305 followers View post →

もぎちゃん

@mogitatsu_max · X

RT @satoshimat28742: @denzaemon_kyoto はじめまして、コメント失礼します

Apr 3, 2025 · 3 shares · 1,610 followers View post →

さとし@鍼灸師

@satoshimat28742 · X

@denzaemon_kyoto はじめまして、コメント失礼します

Apr 2, 2025 · 19 likes · 3 shares · 473 followers View post →

養仁道

@HitoshiTagoh · X

RT @hichachu: https://t.co/fPgA6GPmrh A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis

May 20, 2024 · 2 shares · 1,542 followers View post →

ニューロドクター乱夢

@hichachu · X

https://t.co/fPgA6GPmrh A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis

May 19, 2024 · 3 likes · 2 shares · 4,260 followers View post →

Traditional Medicine Research

@NaLiu1177122 · X

Comment on “A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis” https://t.co/Rf5srtsw0Y https://t.co/Y26FQdf2w8

Mar 21, 2024 · 1 followers View post →

Raising Square Pegs

@RaisingSqrPegs · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/g8dFCjB7j0

Jan 7, 2024 · 649 followers View post →

Evan D Vickers, PhD

@EvanDVickers1 · X

RT @TonyZador: @C_Kavanagh @WiringTheBrain also this cited paper, proposing a mechanism in a mouse model of acupuncture, seems pretty cool…

Dec 30, 2023 · 1 share · 341 followers View post →

Tony Zador

@TonyZador · X

@C_Kavanagh @WiringTheBrain also this cited paper, proposing a mechanism in a mouse model of acupuncture, seems pretty cool "A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis" https://t.co/dCM42NtwAC

Dec 30, 2023 · 5 likes · 1 share · 11,790 followers View post →

希遇

@QuincyMonroe6 · X

@lidangzzz A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis找了一下应该是这篇，还有一篇莹光法的，那篇没找到应该没发在nature上

Sep 16, 2023 · 16 followers View post →

Victor Dill

@victordill · X

@luizpaulor Atencao: o artigo da nature de 2021 é de eletroacunpultura, e não simplesmente acunpultura como colocado. Tem diferença significativa... https://t.co/0psJxEs0zK

Sep 10, 2023 · 1 like · 492 followers View post →

Traditional Medicine Research

@Traditi95990264 · X

Comment on “A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis” https://t.co/GtobaF6cUm https://t.co/FCgWXHc2h6

May 18, 2023 · 29 followers View post →

Rene Sugar

@renesugar · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/J5ANZLqsdt

Apr 26, 2023 · 3,951 followers View post →

RRID Robot

@RobotRrid · X

RRIDs were included in the Nature paper "A neuroanatomical basis for electroacupuncture to…" (https://t.co/E9jpzOwU26). RRIDs like this improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch

Mar 22, 2023 · 161 followers View post →

Dr. Mike Regan, DACM

@DrMikeRegan · X

RT @DrMikeRegan: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Mar 5, 2023 · 1 share · 313 followers View post →

Rene Sugar

@renesugar · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/tUQzVFRTTk

Feb 22, 2023 · 3 likes · 3,951 followers View post →

PrincesAliceWin

@PrincesAliceWin · X

RT @anaconda1030089: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/1XOVaIGHoI

Oct 29, 2022 · 2 shares · 1,215 followers View post →

石添小草

@tomchiukc · X

RT @anaconda1030089: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/1XOVaIGHoI

Oct 29, 2022 · 2 shares · 131 followers View post →

Puffin

@anaconda1030089 · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/1XOVaIGHoI

Oct 29, 2022 · 10 likes · 2 shares · 10,863 followers View post →

Rina Saltman

@rinatie_ceo · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/AycuBGNtYa

Oct 22, 2022 · 3,561 followers View post →

魯迅頭（返璞归真）

@IsharmlaFaith · X

@yatsukusa 一応例もあるよね、この前そこそこヒットになったこれ「A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis」from Nature （迷走神経-副腎軸を引導する電子鍼灸の神経解剖学基礎の一つ）

Oct 18, 2022 · 1 like · 679 followers View post →

Dr. Mike Regan, DACM

@DrMikeRegan · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Oct 8, 2022 · 1 share · 313 followers View post →

Luciaes

@LuciaCampoZgz · X

RT @GERAacupuncture:

Sep 20, 2022 · 8 shares · 360 followers View post →

Dra. Teresa Pascual

@DraTPascual · X

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Marta Rubinos

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@CoranguezNancy · X

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@goret_olivier · X

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@DrMikeRegan · X

RT @DrMikeRegan: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Sep 11, 2022 · 1 share · 313 followers View post →

Dr. Mike Regan, DACM

@DrMikeRegan · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Sep 4, 2022 · 1 share · 313 followers View post →

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@EBM_Acupuncture · X

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Manolito _ educAnestesia

@educanestesia · X

RT @PreuvesAcup:

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CucamongaAcu

@CucamongaAcu · X

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis https://t.co/VqyTOR6PpQ

Jul 10, 2022 · 7 followers View post →

Gilad Wasserman, DMD/MSc

@giladwas · X

@co_yaron @gilboa_mayan אני - שרוב העיסוק שלי הוא רפואת ״איכות חיים״ בעבר הייתי מאוד נגד ובעיקר דיברתי על EBM ועל RCT. אח״כ קצת גדלתי, ואחרי כמה אלפי מטופלים קצת השתנתה לי הגישה. יש דברים קשה לעשות עבורם RCT או שהם מולטיפקטוריאליים (כאב). ויש הפתעות שפתאום צצות בנייצ׳ר: https://t.co/42D3UCMOqg

Mar 29, 2022 · 4 likes · 1,035 followers View post →

张充仁

@TchangJen · X

RT @PreuvesAcup:

Jan 26, 2022 · 6 shares · 17 followers View post →

Marcus Evans

@MarcuswevansSr · X

Author Correction: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis: Nature, Published online: 06 January 2022; doi:10.1038/s41586-021-04290-9Author Correction: A neuroanatomical basis for electroacupuncture to drive the… https://t.co/dVtqaV0qJk

Jan 6, 2022 · 3,614 followers View post →

Bobby

@NotSoTiny_Life · X

Author Correction: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/eR3yi7gIW9

Jan 6, 2022 · 57 followers View post →

Nuno Barata Alves

@NJBarataAlves · X

Author Correction: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/Hz9mFke87A

Jan 6, 2022 · 3 followers View post →

tipthebalanceuk

@tipthebalanceuk · X

Author Correction: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/d7QRLikHcD

Jan 6, 2022 · 25 followers View post →

h0listix

@h0listical · X

Author Correction: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/LS6SAZi9vf https://t.co/UoZ1SXnJxA Nature, Published online: 06 January 2022; doi:10.1038/s41586-021-04290-9 Author Correction: A neuroanatomical basis for electroa…

Jan 6, 2022 · 8 followers View post →

Bala//Zanuriah

@balazanuriah · X

Jan 6, 2022 · 2,495 followers View post →

bernard verdoux

@BVerdoux · X

RT @PreuvesAcup:

Jan 4, 2022 · 6 shares · 6 followers View post →

Dr. Beltrán Carrillo

@ClinicaBeltranC · X

RT @DrMikeRegan: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Dec 14, 2021 · 1 share · 881 followers View post →

Dr. Mike Regan, DACM

@DrMikeRegan · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/4Kx7MZtBFs

Dec 13, 2021 · 2 likes · 1 share · 313 followers View post →

Dra. Nathalie Orens

@DraOrens · X

RT @PreuvesAcup:

Nov 30, 2021 · 6 shares · 422 followers View post →

うさ亀

@ark_pt · X

RT @Chirosamurai: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature 足の三里というのは特別な部位なのか？皮下組織の神経受容器への刺激…

Nov 30, 2021 · 1 share · 790 followers View post →

毒多TKO

@Chirosamurai · X

Nov 29, 2021 · 15 likes · 1 share · 13,214 followers View post →

Dr. Beltrán Carrillo

@ClinicaBeltranC · X

RT @PreuvesAcup:

Nov 29, 2021 · 6 shares · 881 followers View post →

Marta Rubinos

@MartaRubinos · X

RT @PreuvesAcup:

Nov 29, 2021 · 6 shares · 221 followers View post →

Acupuncture preuves & pratiques

@PreuvesAcup · X

Nov 29, 2021 · 11 likes · 6 shares · 519 followers View post →

Researching the Brain

@Brain_Database · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/IGFNFIinQo

Nov 16, 2021 · 1,037 followers View post →

横井健人

@PT_yokoken · X

経穴に鍼をすることで身体におきる生理学的反応が一部解明されてきたようですこういう研究がもっと進むと良いですね A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis - PubMed https://t.co/K7j3kwIlyC

Nov 5, 2021 · 234 followers View post →

TerryCommentary

@TerryCommentary · X

#Acupuncture A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/v4VGw2YGiZ

Nov 2, 2021 · 399 followers View post →

Erik Hom

@erikfyhom · X

Cool...neuro basis for acupuncture... "A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal" axis https://t.co/6zmgeaMHq6

Nov 2, 2021 · 686 followers View post →

Detmar

@d3tm4r · X

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis - PubMed via ⁦@hubermanlab⁩ Podcast So maybe acupuncture is more than pseudo-medicine after all https://t.co/qp1rK9Rdwp

Nov 2, 2021 · 481 followers View post →

Jennifer Dubowsky L.A.c.

@tcm007 · X

RT @EBAcupuncture:

Oct 21, 2021 · 2 shares · 7,968 followers View post →

Ming-Chi Tsai

@MingChiTsai · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/Lj90sRqvbL

Oct 18, 2021 · 454 followers View post →

Hofmann-Apitius

@ApitiusHofmann · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature So macht man das: nicht irgendein esoterischer Vodoo erklärt Effekte von Akupunktur, sondern die guten, alten, bewährten Methoden naturwissenschaftlichen Denkens. https://t.co/WC7zjqsyKL

Oct 18, 2021 · 1,065 followers View post →

Ronald Wang

@ronaldlwang · X

https://t.co/ebAQOA6hUk A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis

Oct 15, 2021 · 63 followers View post →

john morley

@drjohnmorley · X

Liu, S., Wang, Z., Su, Y. et al. A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis. Nature (2021). https://t.co/xzvE8qSFNb

Oct 15, 2021 · 8,323 followers View post →

stephen o'rahilly (its pronounced O-RA-hill-EEE)

@StephenORahilly · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/er5LKDPQe0 Strange: Authors link "adrenal" activity to immunomodulatn. Dont study corticosterone, major immunomodulator, but do study catecholamines, whose effects on immunity are unclear

Oct 15, 2021 · 1 like · 10,078 followers View post →

Marta Rubinos

@MartaRubinos · X

RT @ClinicaBeltranC: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/pkIk3wtTV1

Oct 15, 2021 · 1 share · 221 followers View post →

Devin Nunes' Cattle Dog

@Kaos_Vs_Control · X

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis https://t.co/UrGME9EEb7

Oct 15, 2021 · 1 like · 15,936 followers View post →

Paul McCullough

@ThePostsynaptic · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/Y9J6fGiLDg https://t.co/bAB3WygGIZ

Oct 15, 2021 · 2,590 followers View post →

De Smedt-Schreyen, praktijk voor laseracupunctuur

@Desmedtschreyen · X

RT @EBAcupuncture:

Oct 15, 2021 · 2 shares · 368 followers View post →

Philip Niño Tan-Gatue, MD

@philiptangatue · X

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis - PubMed https://t.co/ukTzfE7y1l

Oct 14, 2021 · 5,560 followers View post →

真・論文書けないマン

@yuseokawa · X

RT @MUMSAIC: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/OUXm5X3lFM

Oct 14, 2021 · 1 share · 257 followers View post →

森ノ宮医療大学鍼灸情報センター

@MUMSAIC · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/OUXm5X3lFM

Oct 14, 2021 · 4 likes · 1 share · 870 followers View post →

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@EBAcupuncture · X

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Oct 14, 2021 · 1 like · 1,684 followers View post →

Know Acupuncture

@KnowAcupuncture · X

RT @JunMaoMD: Very interesting study provided A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature ⁦@SAR…

Oct 14, 2021 · 3 shares · 82 followers View post →

Matteo Morotti

@MMorotti · X

Very nice to see this type of research on Nature! A scientific explanation of old and sometimes effective strategies..A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/8QhGdRyjtY

Oct 14, 2021 · 1 like · 489 followers View post →

Dave Vago

@dave_vago · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/FPeoC77lfT

Oct 14, 2021 · 2,366 followers View post →

Sea

@theseaside22 · X

RT @jfcryan: A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis -in @Nature

Oct 14, 2021 · 1 share · 50 followers View post →

John F. Cryan

@jfcryan · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis -in @Nature https://t.co/xr7KTZvYFt

Oct 14, 2021 · 10 likes · 1 share · 22,442 followers View post →

Inga Williams

@ingridsharp18 · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/vopyvFXb6X

Oct 14, 2021 · 253 followers View post →

Farin B. Bourojeni

@bourojeni · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/oflamRUfrC

Oct 13, 2021 · 210 followers View post →

Zeshaan Maan MD MSc

@znmaan · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature https://t.co/wDgneqFnyg

Oct 13, 2021 · 363 followers View post →

Vitaly Napadow

@VitalyNapadow · X

RT @JunMaoMD: Very interesting study provided A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature ⁦@SAR…

Oct 13, 2021 · 3 shares · 969 followers View post →

Lin Yang

@LYang_Or · X

RT @JunMaoMD: Very interesting study provided A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature ⁦@SAR…

Oct 13, 2021 · 3 shares · 383 followers View post →

Jun J. Mao

@JunMaoMD · X

Very interesting study provided A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis | Nature ⁦@SAR_acuresearch⁩ https://t.co/TOMW85bMDL

Oct 13, 2021 · 8 likes · 3 shares · 1,427 followers View post →

Francis Villatoro

@emulenews · X

#Nature A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/Mac87CeQcg a neuroanatomical basis for the selectivity and specificity of acupoints in driving specific autonomic pathways. https://t.co/sXO8Dni8it

Oct 13, 2021 · 1 like · 45,121 followers View post →

藝人である“Ju•NIOR”【

@aruberutou · X

A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis https://t.co/1GRwBaQSkw https://t.co/FKvkfm8Nzs | #research #manuscripts @nature

Oct 13, 2021 · 203 followers View post →

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis.

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