Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.
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Oct 2021 – Oct 2025Where it's discussed
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AI synopsis
What people are saying
Several posts highlight the significance of lipoprotein(a) as a genetic risk factor, with users referring to the robust findings like those presented in research by Reyes-Soffer. Phrases such as 'must read' and 'game changer' are used to convey urgency and excitement, implying that the conversations are not only informative but reflect a larger movement towards recognizing and addressing this risk factor in cardiovascular health.
Many discussions reflect a supportive stance towards the publication's findings, although there are few critiques indicating complexities.
High levels of curiosity are evident as individuals seek to understand more about lipoprotein(a) and its implications for health.
Discussions indicate a deep dive into the subject, referencing studies, treatment implications, and encouraging testing for lipoprotein(a) levels.
Participants widely perceive the publication as significantly influential, stressing the need for awareness and improved risk assessment.
Abstract in brief
- High levels of lipoprotein(a) [Lpa] are a significant, genetically determined risk factor for atherosclerotic cardiovascular diseases, contributing to increased inflammation and thrombosis.
- Despite the ability to lower LDL cholesterol levels, Lpa remains a persistent risk factor for cardiovascular disease.
- There is an urgent need for standard testing, guidelines, and treatment approaches to lower Lpa, as well as further research on its genetic basis and effects across different ethnic backgrounds.
Top posts
Most liked on X and BlueskyLipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. @LipidoSeen @sociedadSEEN @fjavesc @marubioendocr @jarubiogarcia @mduranm67 https://t.co/nfhA44jsy1 https://t.co/2IiyBxvdZ0
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/YKFvD5MEtK https://t.co/69bAQEF16Z
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association @grsoffer @MarlysLPA & colleagues @American_Heart @ATVBCouncil @CouncilPvd https://t.co/QbOw6XSu52 https://t.co/RWEMxBxIBG
A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/28Ci6mVS7A
Sources: https://t.co/JDNosdP6NV https://t.co/rMrmu9Cd5E https://t.co/PN6NwoMxoZ https://t.co/skpbrBex3b https://t.co/iJDmOyc62b https://t.co/RZTuvoZRMF, https://t.co/55pqQloFrr https://t.co/J18AkpamCF
All mentions
Understanding Lp(a): A Key Risk Factor in Cardiovascular Disease
Have you heard of Lp(a) and its impact on cardiovascular health? High levels of lipoprotein(a) are a significant, genetically determined risk factor. This video explores the confusion surrounding statins and Lp(a)…
Lipoprotein(a): A Key Genetic Risk for Heart Disease Revealed
What if a single blood test could reveal a hidden lifelong risk for heart disease? High levels of lipoprotein(a) are a significant, genetically determined risk factor, contributing to increased inflammation and…
Lipoproteína a | O segredo de muitos infartos
Sources: https://t.co/JDNosdP6NV https://t.co/rMrmu9Cd5E https://t.co/PN6NwoMxoZ https://t.co/skpbrBex3b https://t.co/iJDmOyc62b https://t.co/RZTuvoZRMF, https://t.co/55pqQloFrr https://t.co/J18AkpamCF
@FitFounder Tell that to someone who inherited genetic predisposition to have elevated Lp(a). Or a host of other genetically determined diseases (i.e. breast/ovarian cancer genes (BRCA1, BRCA2)). I get your point, but to say it as an absolute is false. https://t.co/ptOSB68X78
@shikharganjoo Sir - currently it is difficult to target alone but new therapies are coming. Here is an interesting article on the subject - https://t.co/gtruSqkawn
RT @Basalus: 2/ Lp(a) & Atherosclerotic Risk Elevated Lp(a) is an independent, causal risk factor for: •CAD •PAD •Calcific aortic valve ste…
2/ Lp(a) & Atherosclerotic Risk Elevated Lp(a) is an independent, causal risk factor for: •CAD •PAD •Calcific aortic valve stenosis (CAVS) It promotes atherogenesis, inflammation, and thrombosis. [Reyes-Soffer et al., ATVB 2022;42(1):e48-e60] doi:10.1161/ATV.0000000000000147
RT @TeresaArrobas: Reyes-Soffer G,doi: 10.1161/ATV.0000000000000147. Epub 2021 Oct 14. PMID: 34647487;
Reyes-Soffer G,doi: 10.1161/ATV.0000000000000147. Epub 2021 Oct 14. PMID: 34647487;
comparto la bibliografia en la tabla 3. Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):e48-e60.
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association | Arteriosclerosis, Thrombosis, and Vascular Biology https://t.co/RZzGEZaYeN
RT @hsbhatia: This can be incorporated into risk assessment as outlined in the AHA statement on Lp(a). Predicted risk using a traditional r…
This can be incorporated into risk assessment as outlined in the AHA statement on Lp(a). Predicted risk using a traditional risk score can be adjusted to incorporate an elevated Lp(a) level: @grsoffer @calvinyeang https://t.co/FGll7PBL5Z https://t.co/YINXN6oQV8
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https://t.co/b9FMtrBA39
RT @hsbhatia: A similar, more granular approach is detailed in the AHA scientific statement. This document proposed multiplying the 10yr ri…
RT @DrDeepMD: Good primer on Lipoprotein(a) https://t.co/17BSD2jLIi https://t.co/bVOZ6oqJbV
RT @DrDeepMD: Good primer on Lipoprotein(a) https://t.co/17BSD2jLIi https://t.co/bVOZ6oqJbV
RT @DrDeepMD: Good primer on Lipoprotein(a) https://t.co/17BSD2jLIi https://t.co/bVOZ6oqJbV
Good primer on Lipoprotein(a) https://t.co/17BSD2jLIi https://t.co/bVOZ6oqJbV
A similar, more granular approach is detailed in the AHA scientific statement. This document proposed multiplying the 10yr risk by 1.11 for every 50 nmol/L increment of Lp(a) https://t.co/q4REleTjwh
@DoctorTro oops. https://t.co/j0iLmjI0np
@MasalaFry69 @DoctorTro https://t.co/j0iLmjI0np
<3! Raising awareness of Lipoprotein(a) "A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association" https://t.co/2YcvVUnEt6
@envysnest *Rolls up in science and fam history of cardiovascular disease + Normally heavy plant-based diet* Get your lipoprotein (a) checked https://t.co/XldR6uVgyW
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
@theproof @ethanjweiss @DrNadolsky Yes. Lp(a) is an independant risk factor for CVD: https://t.co/ulNl9yYY8v And a causal risk factor for aortic valve stenosis: https://t.co/naeQDaYsDQ https://t.co/R8TLcn1jGI
Lp(a) - going mainstream? saving to read later. #lipids #apoB #lpa Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/RjVEXYYihU
A5: One way to do this was described in the AHA Scientific Statement on Lipoprotein(a) with @grsoffer, Henry Ginsberg, Lars Berglund, Barton Duell, @heffron_sean, Pia Kamstrup, @dmljmd, Santica Marcovina and @MarlysLPA. #Knowlpa https://t.co/H53AyB0t69 https://t.co/bl7ZG8UTSC
A4: For now- optimize other modifiable risk factors control bp, cholesterol, glucose, weight, exercise and diet. #KnowLpa #cholesterol #findLPa #heart health @DrLaxmiMehta @ErinMichos @avolgman @GarimaVSharmaMD @TheFHFoundation https://t.co/KsdZlail8E
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/K7ajd6UHod
RT @MuinJKhoury: Despite its demonstrated contribution to atherosclerotic cardiovascular disease burden, we presently lack standardization…
Despite its demonstrated contribution to atherosclerotic cardiovascular disease burden, we presently lack standardization and harmonization of assays, universal guidelines for diagnosing and providing risk assessment, and targeted treatments to lower Lp(a) https://t.co/8K5aLIlKj7 https://t.co/gk7TRwbKec
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
Documento de posición de #lipoproteina a minúscula. @grsoffer . https://t.co/qP9vfzLWQp Ver video en mi canal: https://t.co/y0XG6n66tY
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. https://t.co/TQyhdLpL6y
RT @HaoYin20: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Sci…
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
@JohnRavalli We now know intra-individual biological variability of Lp(a) is up to 20% suggesting that, for some, a mean of 2 Lp(a) determinations be obtained at different times to refine ASCVD risk stratification https://t.co/G4iBVz23L9
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
RT @MoradiShayan: ICYMI @American_Heart @ATVBCouncil @atvbahajournals Scientific Statment for the Lp(a) Knowledge gaps & future direction…
RT @MoradiShayan: ICYMI @American_Heart @ATVBCouncil @atvbahajournals Scientific Statment for the Lp(a) Knowledge gaps & future direction…
ICYMI @American_Heart @ATVBCouncil @atvbahajournals Scientific Statment for the Lp(a) Knowledge gaps & future directions about atherosclerotic CVD risks & elevated Lp(a) levels @AHAScience @alan_daugherty #CardioTwitter #AHA21 @grsoffer @dmljmd https://t.co/EhjrV45qHQ
RT @brettranders: Fantastic leadership by my #ASPIRE! colleague @grsoffer writing the newly published Lipoprotein(a) guidelines, helping us…
RT @Ed_Alania:
RT @Ed_Alania:
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RT @Ed_Alania:
RT @honglu227: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Sc…
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/m2VMAFZyrM
RT @honglu227: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Sc…
RT @Ed_Alania:
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/UuSlSYRZGI
Fantastic leadership by my #ASPIRE! colleague @grsoffer writing the newly published Lipoprotein(a) guidelines, helping us understand this prevalent, genetic, risk factor for atherosclerotic #CVD. https://t.co/6WM0KraKcD https://t.co/FI5mTlTJPQ
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RT @atvbahajournals: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease…
RT @Ed_Alania:
RT @Ed_Alania:
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Lp(a) level matters https://t.co/RRO6U8Cw5U @society_eas https://t.co/n1wbk2PWMj
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @rafavidalperez: Para saber más sobre Lipoproteina (a) https://t.co/vhVwh0GxyS Lipoprotein(a): A Genetically Determined, Causal, and Pre…
Para saber más sobre Lipoproteina (a) https://t.co/vhVwh0GxyS Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From @American_Heart
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @HaoYin20: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Sci…
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association @grsoffer @MarlysLPA & colleagues @American_Heart @ATVBCouncil @CouncilPvd https://t.co/QbOw6XSu52 https://t.co/RWEMxBxIBG
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association (open access) https://t.co/R7u10PoNoU https://t.co/NiMAIYur0Y
@CardioIAN #CardioTwitter @pabeda1 https://t.co/lEueln9kzd
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @dmljmd: A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Preval…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
A must read on the current knowledge re: this causal risk factor! Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/28Ci6mVS7A
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @grsoffer: https://t.co/zM2kJ3nEiU @Columbia @ATVBEarlyCareer @ATVBCouncil @vascularbiology It was an honor to chair this statement with…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
【備忘】 AHAから、アテローム性動脈硬化リスクとしてのLp(a)に関する公式見解。 基本的に遺伝的素因で決定される因子であるとし、スクリーニングが強く推奨されるのはASCVD [家族] 歴のある例。10年ASCVDイベントリスク予知への反映法も明記。 ATVB https://t.co/ihmBTQltT6 https://t.co/t0ISZXyF6G
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @grsoffer: https://t.co/zM2kJ3nEiU @Columbia @ATVBEarlyCareer @ATVBCouncil @vascularbiology It was an honor to chair this statement with…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @atherosociety: @atherosociety is proud to endorse @ATVBCouncil statement on Lp(a) a very frequent risk factor for ASCVD ! https://t…
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
RT @Drlipid: MUST READ - Official AHA Statement on Lp(a) - endorsed by @atherosociety Call and demand that your lab reports the concentrat…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @NYUCVDPrevent: Curious about the lipoprotein(a)? Dr. Sean Heffron (@heffron_sean) & colleagues at the @American_Heart published a Sci…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
Curious about the lipoprotein(a)? Dr. Sean Heffron (@heffron_sean) & colleagues at the @American_Heart published a Scientific Statement on the important, but under-recognized, risk factor for #heartdisease - Lipoprotein(a).
RT @atvbahajournals: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/PaaQ8LGWKB
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
RT @mbotana: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scie…
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. @LipidoSeen @sociedadSEEN @fjavesc @marubioendocr @jarubiogarcia @mduranm67 https://t.co/nfhA44jsy1 https://t.co/2IiyBxvdZ0
RT @acorderofort: Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A…
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association https://t.co/YKFvD5MEtK https://t.co/69bAQEF16Z