Crit Care Med April 2022 PMID 34661553

Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study.

Philip C Spinella, Julie C Leonard, Barbara A Gaines, James F Luther, Stephen R Wisniewski, Cassandra D Josephson, Christine M Leeper

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Mentions

16
Peak: 4 in Oct 2021
across 4 sources since Oct 2021

Extended reach

19,833
potential audience

Total likes

14

Video views

107

Mentions per month

Oct 2021 – Apr 2023

Where it's discussed

  • X / Twitter9 posts
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The comments reflect strong support for the study, such as calling it an 'Article of Interest' and sharing detailed citations, which indicate active interest and acknowledgment of its importance. The tone and word choices, like 'check out' and 'you should know,' convey enthusiasm and a belief in the study's potential impact on pediatric emergency care.

AgreementModerate agreement

Most discussions acknowledge the value of the study, supporting its positive findings about antifibrinolytics in pediatric hemorrhage.

InterestHigh interest

Participants show high curiosity, with multiple references encouraging others to read the article and highlighting its relevance.

EngagementModerate engagement

Conversations include sharing of article details, referencing specific authors and studies, indicating moderate to deep engagement.

ImpactModerate impact

The discussions suggest that the findings could influence clinical practice and future research priorities.

Abstract in brief

  • The study investigated the use of antifibrinolytic drugs (like tranexamic acid and aminocaproic acid) in children experiencing severe bleeding, finding that these medications were associated with a significant reduction in mortality within 6 hours of bleeding.
  • Children receiving antifibrinolytics had similar baseline characteristics to those who didn't, but they tended to need longer and more intensive transfusions, indicating they might have had more severe bleeding.
  • After adjusting for factors like age and severity of illness, the use of antifibrinolytics still showed a decreased risk of death at both 6 and 24 hours post-bleeding, suggesting these medications could be beneficial in managing pediatric hemorrhage.

Top posts

Most liked on X and Bluesky
StayCurrentMD
@StayCurrentMD · X

Check out this APSA Article of Interest, You Should Know! Spinella, P et al Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage. 2022 doi: 10.1097/CCM.0000000000005383 Check out more on the App: https://t.co/1rFYXYJJuD https://t.co/Tc22t1SUSP

Sep 7, 2022 · 3 likes · 2 shares · 3,891 followers View post →
Catherine R. Counts
@CatherineCounts · X

#ReSS22 Year in Review (Peds) Paper 9: Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study https://t.co/bHfvHiIBX2 https://t.co/auChT3Nv0T

Nov 6, 2022 · 3 likes · 2,662 followers View post →
PEM Updates
@PEMUpdates · X

Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study https://t.co/dLkfZxvLx8 https://t.co/1xZSWCDERx

Oct 31, 2021 · 3 likes · 1 share · 1,457 followers View post →
BloodNet
@BloodNet_PALISI · X

Check out more work from @BloodNet_PALISI members including @PhilSpinellaMD on #antifibrinolytics in life threatening #bleeding #PedsICU https://t.co/8uPLnI3lpl

Oct 19, 2021 · 3 likes · 2 shares · 702 followers View post →
PedsICU_tweets
@PedsICU_tweets · X

RT @BloodNet_PALISI: Check out more work from @BloodNet_PALISI members including @PhilSpinellaMD on #antifibrinolytics in life threatening…

Oct 19, 2021 · 2 shares · 5,466 followers View post →
Todd Ponsky, MD
@tponsky · X

RT @StayCurrentMD: Check out this APSA Article of Interest, You Should Know! Spinella, P et al Use of Antifibrinolytics in Pediatric Life…

Sep 8, 2022 · 2 shares · 3,470 followers View post →

All mentions

Catherine R. Counts
@CatherineCounts · X

#ReSS22 Year in Review (Peds) Paper 9: Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study https://t.co/bHfvHiIBX2 https://t.co/auChT3Nv0T

Nov 6, 2022 · 3 likes · 2,662 followers View post →
GlobalCastMD
@GlobalCastMD · X

RT @StayCurrentMD: Check out this APSA Article of Interest, You Should Know! Spinella, P et al Use of Antifibrinolytics in Pediatric Life…

Sep 8, 2022 · 2 shares · 1,068 followers View post →
Todd Ponsky, MD
@tponsky · X

RT @StayCurrentMD: Check out this APSA Article of Interest, You Should Know! Spinella, P et al Use of Antifibrinolytics in Pediatric Life…

Sep 8, 2022 · 2 shares · 3,470 followers View post →
StayCurrentMD
@StayCurrentMD · X

Check out this APSA Article of Interest, You Should Know! Spinella, P et al Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage. 2022 doi: 10.1097/CCM.0000000000005383 Check out more on the App: https://t.co/1rFYXYJJuD https://t.co/Tc22t1SUSP

Sep 7, 2022 · 3 likes · 2 shares · 3,891 followers View post →
vigiljames
@vigiljames · X

RT @PEMUpdates: Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study https://t.…

Nov 11, 2021 · 1 share · 101 followers View post →
PEM Updates
@PEMUpdates · X

Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study https://t.co/dLkfZxvLx8 https://t.co/1xZSWCDERx

Oct 31, 2021 · 3 likes · 1 share · 1,457 followers View post →
Michaela Waak
@MichaelaWaak · X

RT @BloodNet_PALISI: Check out more work from @BloodNet_PALISI members including @PhilSpinellaMD on #antifibrinolytics in life threatening…

Oct 19, 2021 · 2 shares · 882 followers View post →
PedsICU_tweets
@PedsICU_tweets · X

RT @BloodNet_PALISI: Check out more work from @BloodNet_PALISI members including @PhilSpinellaMD on #antifibrinolytics in life threatening…

Oct 19, 2021 · 2 shares · 5,466 followers View post →
BloodNet
@BloodNet_PALISI · X

Check out more work from @BloodNet_PALISI members including @PhilSpinellaMD on #antifibrinolytics in life threatening #bleeding #PedsICU https://t.co/8uPLnI3lpl

Oct 19, 2021 · 3 likes · 2 shares · 702 followers View post →