Nat Metab October 2021 PMID 34663973

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice.

Heidi H Pak, Spencer A Haws, Cara L Green, Mikaela Koller, Mitchell T Lavarias, Nicole E Richardson, Shany E Yang, Sabrina N Dumas, Michelle Sonsalla, Lindsey Bray, Michelle Johnson, Stephen Barnes, Victor Darley-Usmar, Jianhua Zhang, Chi-Liang Eric Yen

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Mentions

318

Peak: 58 in Oct 2021

across 6 sources since Oct 2021

Extended reach

659,818

potential audience

Total likes

327

Video views

8,334

Mentions per month

Oct 2021 – Jul 2025

Where it's discussed

News182 articles
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Blogs12 articles
Facebook4 posts
Reddit3 posts
YouTube2 videos

AI synopsis

What people are saying

Multiple posts reference the article's key findings, such as the necessity of prolonged fasting periods for achieving metabolic benefits, showcasing a blend of endorsement and critique. Words like 'delighted', 'strong benefits', and phrases like 'game changer' illustrate a tone of enthusiasm, while counterpoints about calorie restriction indicate a nuanced discussion that reflects varying levels of agreement and understanding.

AgreementModerate agreement

Many discussions reflect a supportive view of the publication's findings about fasting and its benefits, though some express skepticism or provide counterpoints.

InterestHigh interest

The topic of fasting generates considerable curiosity as participants mention specific benefits and studies related to metabolic health.

EngagementModerate engagement

While some posts share the article link or basic summary, others delve into detailed discussions and implications, indicating a moderate level of engagement.

ImpactHigh impact

Participants perceive the research as potentially transformative for dietary practices and health, emphasizing its implications for longevity and metabolic health.

Abstract in brief

Fasting plays a crucial role in driving metabolic benefits and promoting longevity, similar to the effects of a calorie-restricted (CR) diet in mice.
Research indicates that prolonged fasting, rather than just reduced caloric intake, triggers key physiological and molecular responses associated with healthy aging.
The study suggests that the timing and practice of fasting are essential factors in regulating metabolic health and enhancing lifespan.

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All mentions

Impact of Fasting on Metabolic Health and Longevity in Mice

Fasting plays a crucial role in driving metabolic benefits and promoting longevity, similar to a calorie-restricted diet in mice. This video explores the physiological and molecular responses associated with fasting and…

医療ニュース解説ステラチャンネル STELLA CHANNEL - 星良孝 · Nov 13, 2021 8,334 views

Fasting and Longevity: Metabolic Benefits Explained

Fasting plays a crucial role in driving metabolic benefits and promoting longevity, similar to the effects of a calorie-restricted diet in mice. This video explores how fasting triggers physiological responses that are…

博士萌 · Jun 23, 2025 0 views

IntegralAnswers

@IntegralAnswers · X

2B/ PubMed Result for PMID 30944421 •Title: Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice •Authors: Mitchell SJ, Bernier M, Mattison JA, et al. •Journal: Nature Metabolism (2019)

Jul 18, 2025 · 9 likes · 7,863 followers View post →

Lamming Lab

@LammingLab · X

@exfatloss @AndyJScott @JohnSpeakman4 It also fits with our work showing the effects of CR require a prolonged fast between meals - PR and IleR mice are fed ad libitum, so don't have this fasting period https://t.co/ouuFkDi3JD

Nov 30, 2023 · 2 likes · 5,836 followers View post →

BillOckham

@BillOccham0 · X

RT @agingdoc1: Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice https://t.co/z4VAqv…

Jul 10, 2023 · 5 shares · 587 followers View post →

Craig TX

@AntiAgingN · X

RT @LammingLab: @siobhanmitchell @Cell_Metabolism @MariaMMihaylova As just one counterpoint, we found that the benefits of CR for frailty,…

Jul 5, 2023 · 2 shares · 867 followers View post →

BillOckham

@BillOccham0 · X

RT @LammingLab: @siobhanmitchell @Cell_Metabolism @MariaMMihaylova As just one counterpoint, we found that the benefits of CR for frailty,…

Jul 2, 2023 · 2 shares · 587 followers View post →

Lamming Lab

@LammingLab · X

@siobhanmitchell @Cell_Metabolism @MariaMMihaylova As just one counterpoint, we found that the benefits of CR for frailty, cognition and longevity in mice require a prolonged fast between meals. Further the metabolic and molecular effects of CR can be recapitulated by imposed fasting w/o reduced calories https://t.co/ouuFkDi3JD

Jul 2, 2023 · 6 likes · 2 shares · 5,836 followers View post →

Patriot Boy Von Milky Way

@HelgerOun · X

RT @agingdoc1: Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice https://t.co/z4VAqv…

Jun 13, 2023 · 5 shares · 9,975 followers View post →

AmericanEgoist

@AmericanEgoist · X