Nutrients September 2021 PMID 34684443

Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis.

Catarina Rodrigues, Alex Pinto, Ana Faria, Diana Teixeira, Annemiek M J van Wegberg, Kirsten Ahring, François Feillet, Conceição Calhau, Anita MacDonald, André Moreira-Rosário, Júlio César Rocha

Mentions

67
Peak: 54 in Jun 2025
across 2 sources since Sep 2021

Extended reach

84,386
potential audience

Total likes

47

Video views

7,215

Mentions per month

Sep 2021 – Jun 2025

Where it's discussed

  • YouTube54 videos
  • X / Twitter13 posts

AI synopsis

What people are saying

These discussions reflect a neutral stance, primarily sharing references to the publication and highlighting the involvement of notable figures such as Louise Robertson, without deep critique or extensive elaboration. The tone remains informational, evidenced by phrases like 'discussing the risk' and sharing links to the research, indicating acknowledgment rather than controversy or enthusiasm.

AgreementNeither agree nor disagree

The discussions mainly acknowledge the publication and its focus but do not strongly agree or disagree with its findings.

InterestModerate interest

There is a mild interest shown, as users reference the article and related discussions, indicating some value placed on the topic.

EngagementNeutral engagement

Engagement appears moderate; posts include mentions of key figures and the study but lack deep analysis or extensive discussion.

ImpactModerate impact

The conversations suggest the study has some influence, especially among professionals, but the overall tone remains superficial.

Abstract in brief

  • A systematic review was conducted to evaluate whether people with phenylketonuria (PKU) are at a higher risk of being overweight compared to healthy individuals due to a phenylalanine-restricted diet.
  • Of 829 articles reviewed, only 15 were included, and the analysis showed that overall, the Body Mass Index (BMI) of PKU patients was similar to that of healthy controls, contradicting the assumption about the diet leading to overweight.
  • However, it was noted that a subgroup of patients with classical PKU had a significantly higher BMI, highlighting the need for ongoing nutritional monitoring and personalized counseling for this population.

Top posts

Most liked on X and Bluesky
Anita MacDonald
@macdonj · X

Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis https://t.co/b0ePh5bCeN via @MDPIOpenAccess

Sep 28, 2021 · 23 likes · 9 shares · 1,914 followers View post →
BIMDG
@BIMDG · X

Louise Robertson discussing the risk of overweight and obesity in PKU, hi-lighted in this paper from 2019. https://t.co/5ANIDMTZyS #BIMDG2022 https://t.co/TOiX0fmRVj

Jun 9, 2022 · 10 likes · 2 shares · 1,213 followers View post →
MDPI
@MDPIOpenAccess · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 44,299 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 6,710 followers View post →
Elena D
@ElenaDF75 · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 30, 2021 · 9 shares · 3,902 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 3,519 followers View post →

All mentions

Louise Robertson
@louisedietitian · X

RT @BIMDG: Louise Robertson discussing the risk of overweight and obesity in PKU, hi-lighted in this paper from 2019. https://t.co/5ANIDMTZ…

Jun 9, 2022 · 2 shares · 2,686 followers View post →
NSPKU
@NSPKU · X

RT @BIMDG: Louise Robertson discussing the risk of overweight and obesity in PKU, hi-lighted in this paper from 2019. https://t.co/5ANIDMTZ…

Jun 9, 2022 · 2 shares · 3,061 followers View post →
BIMDG
@BIMDG · X

Louise Robertson discussing the risk of overweight and obesity in PKU, hi-lighted in this paper from 2019. https://t.co/5ANIDMTZyS #BIMDG2022 https://t.co/TOiX0fmRVj

Jun 9, 2022 · 10 likes · 2 shares · 1,213 followers View post →
Nutr Reviews
@NutrReview · X

Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis https://t.co/tIqKI4cnfW

Oct 25, 2021 · 226 followers View post →
Burcu Öztürk Hişmi
@BurcuHismi · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Oct 4, 2021 · 9 shares · 415 followers View post →
Elena D
@ElenaDF75 · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 30, 2021 · 9 shares · 3,902 followers View post →
NSPKU
@NSPKU · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 29, 2021 · 9 shares · 3,061 followers View post →
MDPI
@MDPIOpenAccess · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 44,299 followers View post →
BCH Metabolics
@MetabolicsBCH · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 2,618 followers View post →
Dr Fatma
@bastakif · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 3,384 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 6,710 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @macdonj: Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systema…

Sep 28, 2021 · 9 shares · 3,519 followers View post →
Anita MacDonald
@macdonj · X

Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis https://t.co/b0ePh5bCeN via @MDPIOpenAccess

Sep 28, 2021 · 23 likes · 9 shares · 1,914 followers View post →