Front Aging Neurosci October 2021 PMID 34707491

Activation of Microbiota Sensing - Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis.

Atefeh Razazan, Prashantha Karunakar, Sidharth P Mishra, Shailesh Sharma, Brandi Miller, Shalini Jain, Hariom Yadav

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Mentions

Peak: 21 in Oct 2021

across 4 sources since Oct 2021

Extended reach

143,692

potential audience

Total likes

Video views

863

Mentions per month

Oct 2021 – Nov 2024

Where it's discussed

News39 articles
X / Twitter26 posts
Blogs5 articles
YouTube2 videos

AI synopsis

What people are saying

The overall discussions demonstrate enthusiasm for the promising role of natural compounds like Fenchol from basil in combating Alzheimer’s, with language like 'could protect,' 'remedies,' and 'natural compounds' conveying hope. The tone is optimistic but measured, emphasizing biological mechanisms and the significance of the gut-brain interaction, which increases the perceived importance of the research in neurodegenerative treatment.

AgreementModerate agreement

Many discussions highlight the potential therapeutic benefits of activating FFAR2, with comments like 'Fenchol can help protect the brain,' indicating general support for the research findings.

InterestHigh interest

Posts frequently reference the link between gut health, compounds like basil, and neuroprotection, showing strong curiosity about new mechanisms and natural compounds.

EngagementHigh engagement

Several discussions delve into specifics, such as the role of Fenchol and the gut-brain axis, reflecting a deep interest in understanding the implications and mechanisms.

ImpactModerate impact

While the discussions underscore potential benefits, the tone suggests cautious optimism rather than certainty, indicating perceived moderate impact but hope for future therapies.

Abstract in brief

The study explores how activating the free fatty acid receptor 2 (FFAR2) signaling pathway, which detects beneficial signals from short chain fatty acids produced by gut microbiota, can reduce neurotoxicity related to Alzheimer’s disease (AD).
Researchers identified a natural compound called Fenchol, found in basil, as an effective activator of FFAR2 that helps protect neuronal cells from amyloid-beta induced damage by enhancing the clearance of amyloid plaques and decreasing cellular aging processes.
The findings suggest that stimulating FFAR2 with compounds like Fenchol could be a promising therapeutic strategy to slow or prevent AD progression by improving proteolysis and reducing neurodegeneration.]

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All mentions

Basil Compound Fenchol May Protect Against Alzheimer's Disease

Fenchol, a natural compound abundant in basil, may help protect the brain against Alzheimer's pathology. It activates the gut microbiome's FFAR2 receptor, reducing neurotoxicity and promoting amyloid clearance, offering…

VHFILM · Oct 6, 2021 624 views

Basil Compound Fenchol and Its Potential in Alzheimer's Treatment

A recent study investigates how Fenchol, a compound in basil, activates the FFAR2 pathway, which may reduce Alzheimer’s neurotoxicity by enhancing amyloid clearance and decreasing cellular aging, suggesting potential…

Anthropoid · Oct 11, 2021 239 views

CherylKyGirl

@sharrell_taylor · X

RT @insightsunlight: @GassmannLori @barristerlawusa True. I once freelanced as a med/legal fact checker. When assigned to find studies to c…

Nov 12, 2024 · 1 share · 1,278 followers View post →

insightsunlight

@insightsunlight · X

@GassmannLori @barristerlawusa True. I once freelanced as a med/legal fact checker. When assigned to find studies to check claims of an abomination of an alzheimers drug that did NOT work, I found actually promising research of things that DID, but wouldn't be profitable for pharma... https://t.co/3IS4yZdnKS https://t.co/9t3uvOk4zh

Nov 12, 2024 · 1 like · 1 share · 1,005 followers View post →

HunterSeven Foundation

@H7Foundation · X

RT @CDMRP: Antioxidants, Vitamin D, Basil leaves--are certain nutrients protective for brain function? Check out the publications supported…

Jun 29, 2022 · 1 share · 2,175 followers View post →

CDMRP

@CDMRP · X

Jun 29, 2022 · 2 likes · 1 share · 3,818 followers View post →

Sarah Blazonis

@SarahBlazonis · X

Here's a link to the study: https://t.co/uarbXj8YZ3 It notes emerging evidence points to the role the gut plays in brain health. Researchers specifically focused on free fatty acid receptor 2. It senses beneficial signals from short chain fatty acids made in the microbiome. @BN9

Mar 3, 2022 · 2,916 followers View post →

Fruit Worms

@fruitWormPapers · X

Activation of Microbiota Sensing - Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis https://t.co/MMmhDi1qxJ

Nov 4, 2021 · 1,248 followers View post →

RRID Robot

@RobotRrid · X

RRIDs were included in the Frontiers in Aging Neuroscience paper "Activation of Microbiota Sensing – Free Fatty Acid…" (https://t.co/YjZNOWe2ov). We appreciate the author's support of reproducibility. #ReproducibleResearch #reproducibility

Nov 4, 2021 · 161 followers View post →

Agingdoc

@agingdoc1 · X

Activation of Microbiota Sensing - Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis https://t.co/79kow2ZA7r

Oct 29, 2021 · 1 like · 42,455 followers View post →

Paperbirds_Neurology

@PaperbirdsN · X

New article: Activation of Microbiota Sensing - Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis https://t.co/t7lR6BnBw1 #alzheimers #neurology https://t.co/8bwyBUST8t

Oct 28, 2021 · 453 followers View post →

Symbiosis papers

@Symbiosispapers · X

Activation of Microbiota Sensing - Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-beta Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis https://t.co/ajz6nvY9Zn

Oct 28, 2021 · 1,108 followers View post →

USF Research

@USFResearch · X

RT @DementiasUK: Researchers from @USouthFlorida have found that Fenchol - a compound found in basil - protected against neurodegeneration…

Oct 15, 2021 · 1 share · 10,396 followers View post →

Dementias Platform UK

@DementiasUK · X

Oct 15, 2021 · 9 likes · 1 share · 6,489 followers View post →

極楽にゃんこ

@kuroneko12960 · X

RT @fdzaraf: Frontiers In Aging Neuroscience. 2021/10/5 微生物叢センシング遊離脂肪酸受容体2シグナル伝達の活性化は,タンパク質分解-老化系の調節によりアミロイド-β 誘発神経毒性を改善する https://t.co/wPx…

Oct 11, 2021 · 5 shares · 1,031 followers View post →

姐御（あっきー）

@YamazukaAkihiro · X

Oct 10, 2021 · 5 shares · 240 followers View post →

oki Ueno

@berlin281010 · X

Oct 10, 2021 · 5 shares · 345 followers View post →

fdzaraf

@fdzaraf · X

Oct 10, 2021 · 30 likes · 5 shares · 13,508 followers View post →

Frédéric Blanc

@BlancFrdric7 · X

https://t.co/OPzNUbA5W4 https://t.co/rVdVBJnd9D

Oct 8, 2021 · 943 followers View post →

Hariom Yadav

@YadavHariom_Sci · X

Natural compound in basil may protect against Alzheimer’s https://t.co/5RgkqgshFA via @YouTube Ralph has explained our study so nicely !!

Oct 8, 2021 · 3 likes · 226 followers View post →

CD BioSciences

@CDBioSciences · X

Scientists at USF Health have discovered a new mechanism that helps neurons sense signals from gut microbes. The findings explained how phenol reduces the Aβ-induced neuronal toxicity in cell cultures and animal models. https://t.co/jsG7mU1Dye

Oct 8, 2021 · 32 followers View post →

Edú Ortega-Ibarra.

@EduOrtegaIbarra · X

Oct 6, 2021 · 34,644 followers View post →

USF Research

@USFResearch · X

RT @USFMicrobiomes: Congrats to @YadavHariom_Sci's team! Have you seen the recently published paper? Check out more about the relationship…

Oct 6, 2021 · 1 share · 10,396 followers View post →

USF Microbiomes Institute

@USFMicrobiomes · X

Oct 6, 2021 · 5 likes · 1 share · 155 followers View post →

Ecology Tweets

@ecology_tweets · X

RT @Palp311: Fenchol a natural compound from basil could protect and ameliorate #Alzheimers disease pathology #plantscience https://t.co/…

Oct 6, 2021 · 1 share · 5,437 followers View post →

Paúl López

@Palp311 · X

Fenchol a natural compound from basil could protect and ameliorate #Alzheimers disease pathology #plantscience https://t.co/5Dpk7l7hd1

Oct 6, 2021 · 1 share · 296 followers View post →

Ivor Goodbody

@IvorGoodbody · X

Meet your new friend, Basil: "Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology." #herbs #MedDiet #ItalianCooking #basil #Alzheimers #dementia https://t.co/wU9u6Z9kYH

Oct 6, 2021 · 1 like · 1,887 followers View post →

Ralph Turchiano

@RalphTurchiano · X

Natural compound in basil may protect against Alzheimer’s https://t.co/D2ag8AI6ab via @YouTube #Fenchol #dementia #basil #alzheimer’s #amyloid #FFAR2 #SCFA #microbiome

Oct 5, 2021 · 128 followers View post →