Authors and commentators overwhelmingly praise the study, citing example figures like 79% remission after just five days and describing the protocol as a potential 'game changer,' with tone emphasizing excitement and confidence in the therapy's potential. This reflects a consensus of strong support and recognition of the study's potential to reshape depression treatment.
AgreementStrong agreement
Most discussions strongly support the effectiveness and transformative potential of Stanford's neuromodulation therapy, highlighting impressive remission rates and praising the study’s findings.
InterestHigh interest
The posts demonstrate high interest, with frequent mention of specific results, protocols, and the promising future of depression treatments, indicating strong engagement with the topic.
EngagementHigh engagement
Many discussions reference detailed data, such as remission percentages and comparison with sham treatments, showing deep involvement and critical engagement with the research.
ImpactHigh impact
The widespread attention, media coverage, and enthusiastic tone suggest that the study has a significant influence on the mental health research community and public perception, signaling high impact.
Abstract in brief
Depression is a significant global health issue, with many patients experiencing treatment-resistant depression, prompting the development of an accelerated therapy called Stanford neuromodulation therapy (SNT), which has shown a high remission rate.
In a study, participants with treatment-resistant depression underwent a sham-controlled trial comparing active and sham SNT, with results measured by the Montgomery-Åsberg Depression Rating Scale.
The active SNT treatment group experienced a significant reduction in depression symptoms (52.5% reduction) compared to the sham group (11.1% reduction), indicating that SNT is a more effective option for this patient population, but further research is necessary to assess its long-term effects.
Thanks for the great chat, @andreashorn_. For those interested, here are our three publications for the SAINT/SNT approach:
1.https://t.co/adzxy64keq
2.https://t.co/p1889amkAg
3.https://t.co/XGMpOaWRur https://t.co/ZnTT69Qhsa
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/59idZr9nYF
Oct 29, 2021 · 12 likes · 1 share · 84 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
Our latest Impact Factor is 14.7! See the article that had the most citations according to the latest Journal Citation Reports https://t.co/pnqMLeBfNw
Jun 23, 2025 · 9 likes · 4 shares · 11,607 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
Our most discussed article of 2022 was an RCT suggesting novel @Stanford #Neuromodulation Therapy to be highly effective for treatment-resistant #depression, as 79% in active treatment reported elimination of depression symptoms after 5 days. https://t.co/qXMONUwFk1 https://t.co/MYwKpjG1ed
Dec 21, 2022 · 6 likes · 3 shares · 11,607 followersView post →
PA
Psychiatry_AUBMC
@AubmcPsychiatry · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind RCT: Almost 80% of the study's participants saw their severe depression go into remission after 1 week of daily treatment with iTBS an accelerated form of rTMS https://t.co/ojViH5ETaZ
Nov 17, 2021 · 6 likes · 2,126 followersView post →
NN
Neuroscience News
@NeuroscienceNew · X
Original Research:
“Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial” by Eleanor J. Cole et al. American Journal of Psychiatry
https://t.co/C8TcQmrlpa
Nov 2, 2021 · 5 likes · 506,664 followersView post →
This video explains TMS as a treatment for depression, including how it works, FDA-approved protocols, effectiveness, side effects, and recent developments. TMS is a noninvasive method that modulates brain activity to…
Discover Stanford Neuromodulation Therapy SNT, an accelerated brain stimulation protocol achieving high remission rates in treatment-resistant depression by targeting brain connectivity with precision. This rapid…
American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses two articles from the January issue, including a trial on Stanford Neuromodulation Therapy showing high remission rates for resistant depression…
Discover Stanford Neuromodulation Therapy SNT, a rapid 5-day protocol achieving high remission rates for treatment-resistant depression by targeting brain connectivity with precision. This neuroscience-informed approach…
RT @APAPubJournals: Our latest Impact Factor is 14.7! See the article that had the most citations according to the latest Journal Citation…
Jun 23, 2025 · 4 shares · 984 followersView post →
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Mike Gara
@garami53 · X
RT @APAPubJournals: Our latest Impact Factor is 14.7! See the article that had the most citations according to the latest Journal Citation…
Jun 23, 2025 · 4 shares · 1,734 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
Our latest Impact Factor is 14.7! See the article that had the most citations according to the latest Journal Citation Reports https://t.co/pnqMLeBfNw
Jun 23, 2025 · 9 likes · 4 shares · 11,607 followersView post →
DM
David Carreon MD
@davidcarreon · X
@DrNiculescuMind @bryan_johnson @_katetolo One of the great things about our RCT was how low the sham response rate was (13% vs 79%). Placebo/sham responses are big when treatment-resistance is low, and by selecting highly treatment resistant patients, we were able to show a huge separation.
https://t.co/HO0DFI7sad https://t.co/yPgqJEvLjk
@NTFabiano @bryan_johnson @_katetolo it's specifically SAINT protocol that has the mentioned 78% success rate. I believe most are referring to this study
https://t.co/umryanVBUo
Mar 18, 2025 · 5 likes · 1 share · 1,122 followersView post →
Jun 5, 2024 · 2 likes · 5,513 followersView post →
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Luke Sjulson
@lukesjulson · X
@evolutionarypsy @sanilrege @Whitneyed2 you're talking about FDA-approved TMS. Have you read anything about the SNT protocol? ECT was my main clinical activity for six years, and I laughed at TMS, but I'm not laughing anymore. It may very well prove to be more effective than ECT
https://t.co/ppoM0NxWJB
Mar 1, 2024 · 2 likes · 7,371 followersView post →
MM
Magnus Medical
@magnusmed · X
A clinical research program for #majordepressivedisorder is now enrolling: https://t.co/6fQk1Hdt1J
*There is a patient cost for this #breakthrough program. Please discuss with your program doctor.
If you or someone you know needs help, call/text 988.
https://t.co/yebkqtpxPD https://t.co/cUTvBmSzKl
@nickcammarata Have you heard about the new transcranial magnetic stimulation protocol being tested at Stanford? "Wireheading" may be able to cure about 60% of all depression. https://t.co/W4HUcc8F5g
I can vouch for this wonderful #neuromodulation course conducted by @aiims_newdelhi.
I got to further my skillset in #rTMS and #brainstimulation.
Attaching the SAINT protocol developed by @NolanRyWilliams
https://t.co/uxHE93Rv03
Attaching my invited piece in @TheHinduScience https://t.co/9Wy2zkvnRV https://t.co/wZMEPnHHkD
Revisiting this excellent paper out of Stanford regarding their radically different protocol for delivering Transcranial Magnetic Stimulation and the great results they saw in patients with severe depressive pathology.. Interested to see where it leads
https://t.co/vgjHfZ2j9E
RT @APAPubJournals: Our most discussed article of 2022 was an RCT suggesting novel @Stanford #Neuromodulation Therapy to be highly effectiv…
Dec 21, 2022 · 3 shares · 5,513 followersView post →
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DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X
RT @APAPubJournals: Our most discussed article of 2022 was an RCT suggesting novel @Stanford #Neuromodulation Therapy to be highly effectiv…
Dec 21, 2022 · 3 shares · 1,465 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
Our most discussed article of 2022 was an RCT suggesting novel @Stanford #Neuromodulation Therapy to be highly effective for treatment-resistant #depression, as 79% in active treatment reported elimination of depression symptoms after 5 days. https://t.co/qXMONUwFk1 https://t.co/MYwKpjG1ed
Dec 21, 2022 · 6 likes · 3 shares · 11,607 followersView post →
LR
Lewis Robinson
@LewRobsie · X
One to watch - Stanford Neuromodulation Therapy using intermittent theta burst stimulation - impressive response and remission rates
https://t.co/dUB3Yltwen
@nickcammarata Me too.
Have you seen this study/protocol from Stanford last year? Magnetic brain stimulation brought rapid remission to almost 80% of participants with severe, treatment-resistant depression. Wild.
https://t.co/RyVHmAjsdC
#depression #brain #mood #antidepressant #NeuroTwitter
After it was shown that antidepressant pills do not really work! #Neuromodulation appears promising.
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial https://t.co/Es3Z160XKZ
Thanks for the great chat, @andreashorn_. For those interested, here are our three publications for the SAINT/SNT approach:
1.https://t.co/adzxy64keq
2.https://t.co/p1889amkAg
3.https://t.co/XGMpOaWRur https://t.co/ZnTT69Qhsa
Jul 7, 2022 · 1 like · 1 share · 5,513 followersView post →
BL
Brain Stimulation Lab
@Stanford_BSL · X
For more information on the study, you can view the full version published by @APAPubJournals #AJP #APA #SNT #Depression #research #TMS https://t.co/cTOMIO1W2l
It also again demonstrates the possible usefulness of MRI in clinical applications of TMS comparable to recent studies showing that optimal antidepressive treatment is achieved, when targeting dlPFC regions that are most strongly connected to the ACC. https://t.co/9GJiesATQL
RT @APAPubJournals: A variant of intermittent theta-burst stimulation, with stimulation guided by brain imaging data, shows promise for pat…
Feb 22, 2022 · 1 share · 5,513 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
AJP Deputy Editor Danny Pine highlights two articles from the February 2022 issue.
https://t.co/XLS0jzu1n9
1/3 https://t.co/nLMytlAaKM
Feb 22, 2022 · 1 like · 11,607 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
A variant of intermittent theta-burst stimulation, with stimulation guided by brain imaging data, shows promise for patients with treatment-resistant depression.
https://t.co/qXMONUOgIB
2/3
Feb 22, 2022 · 3 likes · 1 share · 11,607 followersView post →
LS
Luke Sjulson
@lukesjulson · X
@vineettiruvadi @patrickmineault TMS also https://t.co/d5M3lImmOY
Feb 18, 2022 · 4 likes · 7,371 followersView post →
JA
Journals of The American Psychiatric Association
@APAPubJournals · X
Intermittent theta-burst stimulation as a therapy for treatment-resistant depression.
https://t.co/qXMONUOgIB
4/4
Feb 18, 2022 · 1 like · 11,607 followersView post →
MM
Marli Mesibov
@marsinthestars · X
Love seeing new studies on improving #mentalhealth treatment. https://t.co/i0dJuD2b02
This is cool. Our study about Stanford Neuromodulation Therapy #SNT for depression was the second-most talked about article in 2021 published by @APAPubJournals! #ICYMI https://t.co/cTOMIO1W2l https://t.co/yHBUkCRgGW
Intermittent theta-burst stimulation (iTBS) is approved by the U.S. Food and Drug Administration for the treatment of treatment-resistant depression but is limited by suboptimal efficacy and a 6-week duration.
https://t.co/jmmEm0D8Es
Wow. Trans cranial magnetic stimulation caused an improvement in ~80% of the treatment group. 29 people, double-blind and suffering treatment-resistant depression. Small sample but really exciting.
#depression
https://t.co/qqvosd4i8t
Cole et al: RCT suggest novel @Stanford Neuromodulation Therapy (SNT) highly effective for treatment resistant #depression. After five days, 79% in active treatment entered remission – elimination of depression symptoms, compared to 13% in sham. https://t.co/qXMONUOgIB 5/5
Jan 10, 2022 · 2 likes · 11,607 followersView post →
RS
Reddit Journal of Science
@rsciencejournal · X
Stanford rTMS that reaches 90% remission rate in Major Depression Treatment revised in double blind placebo study: https://t.co/CMuOR0gYTA , #science, #neuroscience, #stanford, #remission
And good news from the SAINT study using high-dose intermittent theta-burst stimulation (iTBS) as well! We might be entering a new era of psychiatric treatments. https://t.co/Dpu0drG6u5
(2/3) "...meet inclusion criteria received either active (N=14) or sham (N=15) SNT. The mean percent reduction from baseline in MADRS score 4 weeks after treatment was 52.5% in the active treatment group and 11.1% in the sham treatment group."
https://t.co/Hz3vnRogTx
Jan 3, 2022 · 2 likes · 4,136 followersView post →
A
Ansia
@AnsiaYY · X
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
'It Saved My Life': Depression Treatment Is Turning Lives Around in Five Days | KQED https://t.co/HfZ0bvUXL7
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial https://t.co/5xTsPVl4YS https://t.co/Ht2EOfAbDz
Dec 21, 2021 · 1 like · 13,884 followersView post →
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NeuroTechSF
@neurotechsf · X
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Dec 9, 2021 · 86 shares · 779 followersView post →
JH
Jungyun Hong
@hongped · X
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
RT @Stanford_BSL: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SAINT) for t…
Nov 22, 2021 · 6 shares · 14,926 followersView post →
TL
Tom C.W. Lin
@TomCWLin · X
Promising, groundbreaking @APAPubJournals study on the use of a new kind of magnetic brain stimulation therapy to treat severe depression based on the hard work of @NolanRyWilliams and his colleagues @Stanford_BSL. https://t.co/ooa3D2SFMS
https://t.co/e3b2Ppkn2w
Nov 22, 2021 · 4 likes · 1 share · 905 followersView post →
PA
Psychiatry_AUBMC
@AubmcPsychiatry · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind RCT: Almost 80% of the study's participants saw their severe depression go into remission after 1 week of daily treatment with iTBS an accelerated form of rTMS https://t.co/ojViH5ETaZ
Nov 17, 2021 · 6 likes · 2,126 followersView post →
AL
Austin Lam
@austinaldenlam · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial https://t.co/3bRHBYnfs3
Nov 16, 2021 · 1 like · 1,084 followersView post →
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Nov 15, 2021 · 86 shares · 2,479 followersView post →
RC
Ryk Comerford
@Truth_Quest30 · X
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Nov 14, 2021 · 86 shares · 2,208 followersView post →
BL
Brain Stimulation Lab
@Stanford_BSL · X
Brain Stim Lab director @NolanRyWilliams on @CBC discussing our recent publication in The American Journal of Psychiatry https://t.co/zezg6DGche https://t.co/jDqLYqEewd
Intermittent theta-burst stimulation (iTBS), a new form of transcranial magnetic stimulation, brought rapid remission to almost 80% of severely depressed participants. https://t.co/aKP6b0mdR3
SNT, a new protocol for intermittent theta burst TMS involving individualised targeting of stimulation, shows great promise in the management of treatment-resistant depression, with side effects of headache and fatigue only: https://t.co/28mPLtWgcj
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Nov 8, 2021 · 86 shares · 149 followersView post →
SS
Shan Siddiqi @shansiddiqi.bsky.social
@shansiddiqi · X
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Nov 8, 2021 · 86 shares · 3,680 followersView post →
BL
Brain Stimulation Lab
@Stanford_BSL · X
The full segment from @CBSSunday featuring @NolanRyWilliams and the results from https://t.co/cTOMIO1W2l please check out the video here https://t.co/8Vpd3ExAV0
RT @NolanRyWilliams: Encouraging data in @APAPubJournals from our double-blinded RCT evaluating Stanford Neuromodulation Therapy (SNT) for…
Nov 7, 2021 · 86 shares · 286 followersView post →
P
P
@psychopharmacol · X
RCT: Stanford neuromodulation therapy (SNT), a high-dose iTBS protocol, was more effective than sham stimulation for TRD. The mean reduction from baseline in MADRS score 4 weeks after treatment was 52.5% vs. 11.1% in the sham treatment group https://t.co/VlkryRyDvy
RT @NolanRyWilliams: https://t.co/XGMpOaFg5R
https://t.co/ilU3LN27VC
We are on CBS Sunday Morning this Sunday. Please RT and spread the wo…
Nov 6, 2021 · 6 shares · 3,526 followersView post →
BL
Brain Stimulation Lab
@Stanford_BSL · X
Big News! Our recent research on depression will be featured this Sunday on @CBSSunday. Tune in to see Stanford Neuromodulation Therapy in action and an interview with our Director @NolanRyWilliams #ajp #SNT #SAINT #depression #cbs https://t.co/gu5DBtFRYh https://t.co/ZfpCmvs0Qq
RT @JRBneuropsiq: "The mean percent reduction in MADRS was 52.5% in the active treatment group and 11.1% in the sham treatment group."
Sta…
Nov 3, 2021 · 1 share · 7,828 followersView post →
JB
Jesus Ramirez-Bermudez
@JRBneuropsiq · X
"The mean percent reduction in MADRS was 52.5% in the active treatment group and 11.1% in the sham treatment group."
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/R7kT5nKaFZ
Nov 3, 2021 · 3 likes · 1 share · 31,457 followersView post →
NN
Neuroscience News
@NeuroscienceNew · X
Original Research:
“Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial” by Eleanor J. Cole et al. American Journal of Psychiatry
https://t.co/C8TcQmrlpa
Nov 2, 2021 · 5 likes · 506,664 followersView post →
MG
Mike Gara
@garami53 · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/7PVdzij98j
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/9cCk4GrPTm. #MedTwitter #healthcare #Mentalhealth #depression #psychtwitter #Psychiatry
Nov 1, 2021 · 5 likes · 1 share · 532 followersView post →
Lバ
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X
RT @Luke_629: Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t…
Oct 30, 2021 · 1 share · 2,278 followersView post →
CR
Carolyn Rodriguez
@CRodriguezMDPhD · X
RT @BrandonBentzley: Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry ht…
Oct 30, 2021 · 1 share · 4,326 followersView post →
Lバ
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/QZIXdAzXGs #TMS #MRI #depression
Oct 29, 2021 · 1 like · 1 share · 2,278 followersView post →
BB
Brandon Bentzley
@BrandonBentzley · X
Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial | American Journal of Psychiatry https://t.co/59idZr9nYF
Oct 29, 2021 · 12 likes · 1 share · 84 followersView post →
F
Thomas Hart Middle School PTSA | Pleasanton CA - Facebook
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