Nutr J October 2021 PMID 34719399

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.

Olha Barna, Pavlo Lohoida, Yurii Holovchenko, Andrii Bazylevych, Valentyna Velychko, Iryna Hovbakh, Larysa Bula, Michael Shechter

Mentions

49
Peak: 19 in Nov 2021
across 6 sources since May 2021

Extended reach

438,089
potential audience

Total likes

404

Video views

5,240

Mentions per month

May 2021 – Dec 2025

Where it's discussed

  • X / Twitter30 posts
  • Facebook5 posts
  • Instagram4 posts
  • TikTok4 posts
  • Reddit4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall sentiment displays strong agreement with the study’s findings, exemplified by phrases like 'magnesium was shown to be effective and safe,' and the emphasis on its potential therapeutic role. The tone is positive and aimed at sharing notable results, with a few discussions asking for advice or elaboration, reflecting moderate interest and engagement without extensive critical debate.

AgreementStrong agreement

Most discussions clearly support the study, citing its positive findings and emphasizing magnesium's effectiveness and safety.

InterestModerate interest

Posts show moderate curiosity, referencing the study as a significant finding and sharing summaries, but lack deep detailed analysis.

EngagementModerate engagement

Participants engage by referencing specific study outcomes and asking for advice, indicating some involvement but not extensive debate.

ImpactHigh impact

Many discussions highlight magnesium's potential as an effective treatment, suggesting the findings could influence opinions and practices regarding nocturnal leg cramps.

Abstract in brief

  • A randomized, double-blind, placebo-controlled study in Ukraine found that magnesium oxide monohydrate (MOMH) significantly reduces the frequency and duration of nocturnal leg cramps (NLC) and improves sleep quality more than a placebo.
  • Participants taking MOMH experienced a higher decrease in NLC episodes and better overall sleep compared to those on placebo, with safety confirmed.
  • The study supports the potential use of MOMH as an effective treatment for NLC, addressing previous gaps due to lack of evidence on cellular absorption of magnesium supplements.]

Top posts

Most liked on X and Bluesky
J P Fanton
@HealthyFellow · X

A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps https://t.co/ga2ttlguoB Attn: @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @Grimhood @LocalRachel @deNutrients @DrPalmquist @shashiiyengar @heniek_htw @SatchinPanda

Nov 5, 2021 · 37 likes · 12 shares · 25,967 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Magnesium supplementation is effective in the treatment of nocturnal leg cramps.

Jan 7, 2022 · 23 likes · 2 shares · 24,148 followers View post →
Dr. Jan-Frieder Harmsen
@247muscle · X

The first study to the best of my knowledge providing evidence that supplementing #magnesium prevents nocturnal leg #cramps beyond a placebo-effect! @NutrJournal https://t.co/1lc5pkTjhg https://t.co/yBOaqGJy02

Nov 22, 2021 · 10 likes · 3,656 followers View post →
松田干城 Tateki Matsuda
@TatekiMatsuda · X

ウクライナで175人がMgサプリ226mgを1日1回、就寝時に60日間投与、夜間の足痙攣が良くなり睡眠の質が向上 #マグ活  ⁦⁦⁦@MayoNunokawa⁩ ⁦@YoubiHealthcare⁩ the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps https://t.co/aNVdlbSvTG

Nov 12, 2021 · 10 likes · 3 shares · 1,582 followers View post →
Magnesium Girl - yin solutions for a yang world
@LocalRachel · X

Magnesium for night leg cramps: ✅ "A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps" (NLC) study: https://t.co/DTx5vPhmdZ

Oct 4, 2023 · 5 likes · 8,848 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate ... https://t.co/gbFOKqxWpC

Oct 4, 2023 · 2 likes · 1 share · 1,072 followers View post →

All mentions

Kille Tölönen
@Neonomide · X

@jjkoivukangas @JuhaniKnuuti Ainakin magnesiumoksidi toiminut joissain tutkimuksissa yöllisiin jalkakramppeihin, esim: https://t.co/H9sTd1ko86

Nov 22, 2024 · 1 like · 935 followers View post →
Dr. Adrian Laurence
@adrianrlaurence · X

[1] O. Barna et al., “A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps,” Nutrition Journal, vol. 20, Apr. 2021, doi: 10.1186/s12937-021-00747-9. [2] Yijia Zhang et al.,

Sep 12, 2024 · 128 followers View post →
Markus Lehtonen
@MarkusLehtone14 · X

RT @KingManninen: A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate .…

Oct 4, 2023 · 1 share · 91 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate ... https://t.co/gbFOKqxWpC

Oct 4, 2023 · 2 likes · 1 share · 1,072 followers View post →
Magnesium Girl - yin solutions for a yang world
@LocalRachel · X

Magnesium for night leg cramps: ✅ "A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps" (NLC) study: https://t.co/DTx5vPhmdZ

Oct 4, 2023 · 5 likes · 8,848 followers View post →
Sood A K
@malikasood · X

@theliverdr @tukrut Your advice please "MOMH was shown to be effective in the treatment of NLC as well as safe and well-tolerated." https://t.co/OD9cjGRfXe

Aug 5, 2023 · 215 followers View post →
DrJ
@DrNoci · X

@joe_kyle_is_me @RupaliChadhaMD @calleymeans @joerogan https://t.co/6xuUncfBWw #1 in my class and 17 years of experience. I doubt you’ll teach me anything.

Jun 22, 2023 · 252 followers View post →
Noemi Cuenca (Dietista-Nutricionista)
@noemicuencaq · X

RT @john_damianosMD: Magnesium supplementation is effective in the treatment of nocturnal leg cramps.

Jan 7, 2022 · 2 shares · 536 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

https://t.co/gco3cWTZkn

Jan 7, 2022 · 1,072 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Magnesium supplementation is effective in the treatment of nocturnal leg cramps.

Jan 7, 2022 · 23 likes · 2 shares · 24,148 followers View post →
Nutrition@BMC
@NutritionBMC · X

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps: https://t.co/CiqU7Xn6L3

Nov 30, 2021 · 759 followers View post →
Dr. Jan-Frieder Harmsen
@247muscle · X

The first study to the best of my knowledge providing evidence that supplementing #magnesium prevents nocturnal leg #cramps beyond a placebo-effect! @NutrJournal https://t.co/1lc5pkTjhg https://t.co/yBOaqGJy02

Nov 22, 2021 · 10 likes · 3,656 followers View post →
布川麻代
@MayoNunokawa · X

RT @TatekiMatsuda: ウクライナで175人がMgサプリ226mgを1日1回、就寝時に60日間投与、夜間の足痙攣が良くなり睡眠の質が向上 #マグ活  ⁦⁦⁦@MayoNunokawa⁩ ⁦@YoubiHealthcare⁩ the efficacy of ma…

Nov 12, 2021 · 3 shares · 145 followers View post →
松田干城 Tateki Matsuda
@TatekiMatsuda · X

ウクライナで175人がMgサプリ226mgを1日1回、就寝時に60日間投与、夜間の足痙攣が良くなり睡眠の質が向上 #マグ活  ⁦⁦⁦@MayoNunokawa⁩ ⁦@YoubiHealthcare⁩ the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps https://t.co/aNVdlbSvTG

Nov 12, 2021 · 10 likes · 3 shares · 1,582 followers View post →
Sasera
@Sasera_beauty · X

الاشخاص اللي اخذوا ٢٢٦ ملغم من اوكسيد المغنسيوم الMonohydrate مره يوميا قبل النوم ل٦٠ يوم لاحظوا تحسن في تشنجات الساق الليليه وجودة النوم. فإستنتجوا انه يبدو ان المغنسيوم يفيد في هالمشكله (في الأشخاص غير الحوامل) (دراسه صغيره جديده) https://t.co/k5LeLWl8gy https://t.co/r13v1Vghp3

Nov 9, 2021 · 2 likes · 253 followers View post →
Nick Krontiris
@nick_krontiris · X

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps (open access) https://t.co/LvGCTy0vtP #supplements #supplement #nutrition #diet

Nov 7, 2021 · 1 like · 19,556 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 7, 2021 · 12 shares · 28,690 followers View post →
Maurício Lima
@dj_surfista · X

O óxido de magnésio monohidratado demonstrou ser eficaz no tratamento de cãibras noturnas nas pernas, bem como seguro e bem tolerado. #Magnesium https://t.co/Am9Coz4cgW

Nov 6, 2021 · 757 followers View post →
Rodrigo Nunes Cal
@CalZole · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 6, 2021 · 12 shares · 3,334 followers View post →
Bongani Mayosi Health Sciences Library (BMHSL)
@uct_bmhsl · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 6, 2021 · 12 shares · 1,587 followers View post →
Carlos Colmenero
@colme99 · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 6, 2021 · 12 shares · 77 followers View post →
WeAreTheWorld
@pet41159566 · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 589 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 124,931 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 6,789 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 10,293 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 29,700 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 133,232 followers View post →
Batman Arkham
@batimov · X

RT @HealthyFellow: A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps ht…

Nov 5, 2021 · 12 shares · 2,537 followers View post →
J P Fanton
@HealthyFellow · X

A randomized, double-blind, placebo-controlled study assessing the efficacy of #magnesium for #nocturnal #leg #cramps https://t.co/ga2ttlguoB Attn: @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @Grimhood @LocalRachel @deNutrients @DrPalmquist @shashiiyengar @heniek_htw @SatchinPanda

Nov 5, 2021 · 37 likes · 12 shares · 25,967 followers View post →
Research Square Covid-19 Preprints
@RS_COVID19 · X

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Assessing the Efficacy of Magnesium Oxide Monohydrate in the Treatment of Nocturnal Leg Cramps #covid https://t.co/UrGALqMkHP

May 3, 2021 · 1 like · 637 followers View post →
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com/articles/10.1186/1550-2783-10-48 #Blackmores #นอนดีสุขภาพดี #JointSupport ... doi: 10.1186/s12937-021-00747-9. PMID: 34719399; PMCID: PMC8559389 ...

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Nutr J. 2021; 20(1):90 doi: 10.1186/s12937-021-00747-9 · No photo description available.

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... 10.1186/s12937-021-00747-9 ‏Shechter et al., Magnesium Research (2012) – doi:10.1684/mrh.2012.0305 דו”ח משרד הבריאות: Magnesium-HEB-2024-2 ...

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מקורות מדעיים: Barna et al., Nutr J (2021) – https://doi.org/10.1186 ...
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מקורות מדעיים: Barna et al., Nutr J (2021) – https://doi.org/10.1186/s12937-021-00747-9 Shechter et al., Magnesium Research (2012) –...

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מקורות מדעיים: ‏Barna et al., Nutr J (2021) – https://doi.org/10.1186/...
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... 10.1186/s12937-021-00747-9 ‏Shechter et al., Magnesium Research (2012) – doi:10.1684/mrh.2012.0305 דו”ח משרד הבריאות: Magnesium-HEB-2024-2 ...

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https://nutritionj.biomedcentral.com/articles/10.1186/s12937-021-00747-9. Cramping in general and magnesium supplements have been studied ...

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