Anesthesiology December 2021 PMID 34731232

Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desflurane and Sevoflurane Elimination Kinetics.

James E Baumgardner, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg, Thomas Schilling, Anders Larsson, Göran Hedenstierna

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Mentions

Peak: 3 in Nov 2021

across 3 sources since May 2021

Extended reach

40,216

potential audience

Total likes

Video views

Mentions per month

May 2021 – Nov 2021

Where it's discussed

X / Twitter3 posts
Facebook2 posts
YouTube1 videos

AI synopsis

What people are saying

This collection of discussions highlights a strong interest in the article, with phrases such as 'discusses' and 'presented at grand rounds,' reflecting active engagement. The emphasis on the significance of the topic and the involvement of expert voices convey a positive reception and recognition of its relevance to clinical practice and research.

AgreementModerate agreement

Most discussions indicate recognition of the study's relevance, with some expressing support for its findings on anesthetic elimination kinetics.

InterestHigh interest

Posts show high curiosity, as evidenced by enthusiastic language like 'discusses' and mentions of upcoming presentations and podcasts.

EngagementModerate engagement

Participants actively engage by referencing specific experts, events, and further exploration of the topic, but do not delve deeply into technical critique.

ImpactModerate impact

The emphasis on discussions by prominent figures and planned presentations suggests moderate impact within the anesthesiology community.

Abstract in brief

The study investigates how the ventilation-perfusion ratio (VAQ) in the lungs affects the elimination speed of the anesthetics desflurane and sevoflurane, developing a mathematical model to predict washout times based on VAQ.
Results show that VAQ influences the entire elimination process, with lower VAQ ratios causing slower tissue washout, especially in the later stages, highlighting the lung's ongoing role in anesthetic clearance beyond initial phases.
The model and experimental data suggest that the corrected time constant for tissue washout, accounting for incomplete lung clearance, is a better predictor of elimination kinetics during the entire process than the intrinsic tissue time constant.

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All mentions

Impact of Ventilation-Perfusion Ratio on Anesthetic Washout in Normal Lungs

This study investigates how the ventilation-perfusion ratio affects the elimination of desflurane and sevoflurane, developing a model to predict washout times. Results indicate VAQ influences entire elimination, with…

AJE Video Bytes · Nov 17, 2021 95 views

Hugo Perez

@hugop_perez · X

RT @_Anesthesiology: Editor-in-Chief Evan Kharasch discusses the Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desf…

Nov 24, 2021 · 1 share · 291 followers View post →

Anesthesiology Journals

@_Anesthesiology · X

Nov 24, 2021 · 6 likes · 1 share · 38,238 followers View post →

Pitt Anesthesiology and Perioperative Medicine

@PittAnes · X

May 17, 2021 · 1,589 followers View post →