November 2021 PMID 34732695

Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial.

Olof R Hjorth, Andreas Frick, Malin Gingnell, Johanna M Hoppe, Vanda Faria, Sara Hultberg, Iman Alaie, Kristoffer N T Månsson, Jörgen Rosén, Margareta Reis, Kurt Wahlstedt, My Jonasson, Mark Lubberink, Gunnar Antoni, Mats Fredrikson

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Mentions

Peak: 7 in Feb 2022

across 4 sources since Nov 2021

Extended reach

60,592

potential audience

Total likes

Video views

594

Mentions per month

Nov 2021 – Apr 2024

Where it's discussed

News21 articles
X / Twitter13 posts
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The discussions highlight the significance of expectancy effects on treatment outcomes, referencing results such as increased responder rates with overt treatment and the psychological influence on dopamine systems. The tone varies from supportive to curious, with some posts questioning the clinical relevance, which collectively shows a moderate influence on current understanding and interest in psychological factors during SSRI therapy.

AgreementModerate agreement

Most discussions recognize the study’s findings that expectancy influences dopaminergic activity and treatment response, indicating general support for the article’s conclusions.

InterestModerate interest

Posts show moderate interest, mentioning specific results like the difference between overt and covert SSRI treatments and the psychological effects involved.

EngagementModerate engagement

The discussions delve into the implications of expectancy effects and treatment efficacy, reflecting a decent level of engagement and analysis.

ImpactModerate impact

Participants consider the research findings impactful, discussing potential implications for clinical practices and understanding of SSRI mechanisms.

Abstract in brief

This clinical trial investigated how expectancy (what patients believe about their treatment) influences brain chemistry and symptom outcomes in social anxiety disorder patients taking SSRIs, specifically escitalopram.
The study found that actual serotonin transporter occupancy was similar regardless of expectancy, but changes in dopamine transporter activity varied depending on whether patients knew they were receiving active medication or a placebo, impacting symptom improvement.
These results suggest that the psychological aspect (expectancy) can affect dopamine systems involved in anxiety, indicating that SSRIs may work partly through psychological and dopaminergic mechanisms beyond just serotonin transporter blockade.

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All mentions

Impact of Expectancy on Brain Chemistry in SSRI Treatment for Social Anxiety

This clinical trial investigates how patient beliefs influence brain chemistry and symptom outcomes in social anxiety disorder patients taking SSRIs, highlighting the psychological effects on dopamine systems beyond…

Maudsley Learning · Feb 21, 2022 521 views

The Impact of Optimism on Brain Chemistry and Wellbeing

This video explores how optimism influences brain function and mental health, highlighting its benefits and effects on the brain's neurochemistry, particularly in how we perceive and respond to our environment…

Kelvin Corrêa · Oct 30, 2023 74 views

BillOckham

@BillOccham0 · X

RT @JesseMalkin12: @ChrisPalmerMD "Overt was superior to covert SSRI treatment, resulting in almost a fourfold higher rate of responders."…

Apr 4, 2024 · 2 shares · 582 followers View post →

Vladimir Heiskanen

@ValtsuH · X

RT @JesseMalkin12: @ChrisPalmerMD "Overt was superior to covert SSRI treatment, resulting in almost a fourfold higher rate of responders."…

Sep 12, 2022 · 2 shares · 813 followers View post →

Jesse Malkin

@JesseMalkin12 · X

@ChrisPalmerMD "Overt was superior to covert SSRI treatment, resulting in almost a fourfold higher rate of responders." https://t.co/IC7mVj0Uhx

Sep 12, 2022 · 6 likes · 2 shares · 44 followers View post →

CSI Lab

@CSI_Lab_ · X