Pharmacotherapy January 2022 PMID 34752647

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.

Seenae Eum, Franklin Sayre, Adam M Lee, Julia C Stingl, Jeffrey R Bishop

Mentions

33
Peak: 7 in Nov 2021
across 5 sources since Nov 2021

Extended reach

30,242
potential audience

Total likes

83

Video views

7,490

Mentions per month

Nov 2021 – Dec 2025

Where it's discussed

  • TikTok18 posts
  • X / Twitter7 posts
  • Facebook5 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

The discussions reflect a positive reception, with comments highlighting the importance of the research, such as the mention that CYP2B6 polymorphisms influence drug exposure and the potential for personalized dosing. Phrases like 'Opportunities to study' and references to 'meta-analysis of 10 studies' indicate a serious, analytical tone that underscores the significance and relevance of these findings in clinical contexts.

AgreementModerate agreement

Most posts acknowledge the significance of the research findings, particularly emphasizing the genetic influence on drug metabolism.

InterestHigh interest

Discussions demonstrate high interest, with mentions of precision medicine and genetic testing as promising avenues.

EngagementModerate engagement

Posts show moderate engagement by referencing details like the number of studies and potential clinical implications.

ImpactModerate impact

The studies are seen as potentially impactful, especially concerning personalized treatment strategies and the future of pharmacogenetics.

Abstract in brief

  • This study investigates how different genetic variations (polymorphisms) in the CYP2B6 enzyme affect the levels of bupropion and its active metabolite, hydroxybupropion, in the blood, through a systematic review and meta-analysis.
  • The research found that individuals carrying the CYP2B6*6 allele, especially poor and intermediate metabolizers, have significantly lower exposure to bupropion and hydroxybupropion compared to those with normal metabolism, indicating genetic differences impact drug metabolism.
  • The findings highlight the importance of CYP2B6 genetic testing to potentially optimize bupropion dosing and improve treatment effectiveness, as genetic variations influence how the drug is processed in the body.]

Top posts

Most liked on X and Bluesky
Chad Bousman
@BousmanChad · X

Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had sig lower exposure to bupropion + hydroxybupropion (active moiety) relative to normal metabolizers. @pgrnhub @cpicpgx @PharmacoJournal https://t.co/OCCFV7wcG0

Nov 13, 2021 · 20 likes · 4 shares · 852 followers View post →
Pharmacotherapy
@PharmacoJournal · X

The findings of this study suggest opportunities to further study precision dosing strategies for bupropion therapy based on CYP2B6 genotype. https://t.co/RzS5wM4Xrd @pkpdpg https://t.co/NNyqVATZfJ

Nov 17, 2021 · 3 likes · 11,870 followers View post →
Garbiñe Lizeaga
@GarbineLizeaga · X

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta‐analysis https://t.co/dgskJ6tzuR

Nov 16, 2021 · 1 like · 1,223 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 13, 2021 · 4 shares · 6,686 followers View post →
Ruslan Dorfman
@RuslanDorfman · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 15, 2021 · 4 shares · 1,009 followers View post →
PSY-PGx
@PSY_PGx · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 14, 2021 · 4 shares · 488 followers View post →

All mentions

Pharmacotherapy
@PharmacoJournal · X

The findings of this study suggest opportunities to further study precision dosing strategies for bupropion therapy based on CYP2B6 genotype. https://t.co/RzS5wM4Xrd @pkpdpg https://t.co/NNyqVATZfJ

Nov 17, 2021 · 3 likes · 11,870 followers View post →
Garbiñe Lizeaga
@GarbineLizeaga · X

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta‐analysis https://t.co/dgskJ6tzuR

Nov 16, 2021 · 1 like · 1,223 followers View post →
Ruslan Dorfman
@RuslanDorfman · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 15, 2021 · 4 shares · 1,009 followers View post →
PSY-PGx
@PSY_PGx · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 14, 2021 · 4 shares · 488 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 13, 2021 · 4 shares · 6,686 followers View post →
Francois Bernier
@Genedoc35 · X

RT @BousmanChad: Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had…

Nov 13, 2021 · 4 shares · 345 followers View post →
Chad Bousman
@BousmanChad · X

Meta-analysis of 10 studies in healthy people (n=413) found CYP2B6 genotype-inferred poor & intermediate metabolizers had sig lower exposure to bupropion + hydroxybupropion (active moiety) relative to normal metabolizers. @pgrnhub @cpicpgx @PharmacoJournal https://t.co/OCCFV7wcG0

Nov 13, 2021 · 20 likes · 4 shares · 852 followers View post →
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