November 2021 PMID 34847963

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement.

Jonathan P Jacobs, Arpana Gupta, Ravi R Bhatt, Jacob Brawer, Kan Gao, Kirsten Tillisch, Venu Lagishetty, Rebecca Firth, Gregory D Gudleski, Benjamin M Ellingson, Jennifer S Labus, Bruce D Naliboff, Jeffrey M Lackner, Emeran A Mayer

Mentions

49
Peak: 14 in Dec 2021
across 6 sources since Nov 2021

Extended reach

141,768
potential audience

Total likes

118

Video views

941

Mentions per month

Nov 2021 – Oct 2025

Where it's discussed

  • X / Twitter37 posts
  • Facebook5 posts
  • YouTube2 videos
  • News2 articles
  • Blogs2 articles
  • Instagram1 posts

AI synopsis

What people are saying

Discussions reflect strong support and interest, frequently referencing specific biological markers, such as serotonin levels and microbiome shifts, with tone emphasizing scientific curiosity and optimism about future treatment implications; words like 'fascinating,' 'helpful,' and 'supporting' highlight the positive tone and impact of the research.

AgreementModerate agreement

The majority of discussions support the positive findings of the study, emphasizing the therapeutic potential of CBT in modifying the brain-gut-microbiome axis for IBS improvement.

InterestHigh interest

Posts demonstrate high interest, often referencing specific mechanisms, such as the microbiome and serotonin levels, and praising the research's significance, indicating enthusiastic engagement.

EngagementModerate engagement

Most discussions delve into the biological processes, citing examples like shifts in microbiome composition and brain network changes, showing a thoughtful engagement with the science.

ImpactModerate impact

Participants recognize the study's importance in advancing understanding of IBS treatment, mentioning potential for better therapies and increased buy-in from patients and clinicians, reflecting a moderate to high impact perception.

Abstract in brief

  • This study explores how cognitive behavioral therapy (CBT) can lead to changes in the brain and gut microbiome that are linked to improvements in irritable bowel syndrome (IBS) symptoms.
  • Researchers found that baseline gut microbiome and brain features, such as specific bacterial populations and serotonin levels, can predict how well a patient responds to CBT.
  • After treatment, responders showed significant brain changes and microbiome shifts, indicating a bidirectional relationship between the gut and brain that influences symptom relief.]

Top posts

Most liked on X and Bluesky
Microbiome
@MicrobiomeJ · X

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement https://t.co/9GiSD490Q3

Nov 30, 2021 · 14 likes · 8 shares · 20,469 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 7, 2021 · 13 likes · 6 shares · 24,036 followers View post →
Sultan Mahmood MD
@SultanMahmoodMD · X

Fascinating study by my colleague @Jeff_Lackner and colleagues showing that patients responding to CBT had different gut microbiome than non responders. There is co-correlated shifts in brain networks and gut microbiome with CBT #gitwitter

Jan 11, 2022 · 12 likes · 2 shares · 7,047 followers View post →
Emeran Mayer, MD
@EmeranMayerMD · X

In 2016, we were the first to show that the ingestion of a #probiotic cocktail can alter brain function in healthy young women. We now show that normalizing brain function in patients with #IBS by CBT can influence the #gutmicrobiome. Check it out at https://t.co/UMy656A1eT

Dec 1, 2021 · 12 likes · 1 share · 4,452 followers View post →
Emeran Mayer, MD
@EmeranMayerMD · X

Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It targets the fear, hypervigilance, and catastrophizing coping style that fuel #IBS. #GITwitter #MedTwitter #IBSAwarenessMonth @UCLAGIHep https://t.co/qM9zauhOtT

Apr 6, 2025 · 11 likes · 5 shares · 4,452 followers View post →
Arpana Church
@ArpanaChurch · X

We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner #UCLAGI @UCLAHealth https://t.co/NsMQPmzNYc

Nov 30, 2021 · 7 likes · 4 shares · 789 followers View post →

All mentions

Dr S S Hasan
@hasan20187 · X

RT @EmeranMayerMD: Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It t…

Apr 14, 2025 · 5 shares · 1,811 followers View post →
Mart
@Mart23265574799 · X

RT @EmeranMayerMD: Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It t…

Apr 12, 2025 · 5 shares · 50 followers View post →
UCLA Gastroenterology and Hepatology
@UCLAGIHep · X

RT @EmeranMayerMD: Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It t…

Apr 6, 2025 · 5 shares · 1,551 followers View post →
Emma Brown
@patientfirsteb · X

RT @EmeranMayerMD: Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It t…

Apr 6, 2025 · 5 shares · 36 followers View post →
htw
@heniek_htw · X

RT @EmeranMayerMD: Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It t…

Apr 6, 2025 · 5 shares · 11,358 followers View post →
Emeran Mayer, MD
@EmeranMayerMD · X

Cognitive Behavioral Therapy (CBT) aims to reduce the behavioral and biological aspects of stress hyperreactivity. It targets the fear, hypervigilance, and catastrophizing coping style that fuel #IBS. #GITwitter #MedTwitter #IBSAwarenessMonth @UCLAGIHep https://t.co/qM9zauhOtT

Apr 6, 2025 · 11 likes · 5 shares · 4,452 followers View post →
cjd
@grimmiedforlife · X

RT @RomeGastroPsych: Evolving data DOES highlight #microbiome & #brain factors involved in response to #CBTWorks - This is helpful for fra…

May 6, 2023 · 2 shares · 58 followers View post →
Garry Spink, PhD
@SpinkGarry · X

RT @RomeGastroPsych: Evolving data DOES highlight #microbiome & #brain factors involved in response to #CBTWorks - This is helpful for fra…

Nov 10, 2022 · 2 shares · 156 followers View post →
Rome PsychoGastroenterology
@RomeGastroPsych · X

Evolving data DOES highlight #microbiome & #brain factors involved in response to #CBTWorks - This is helpful for framing and supporting buy-in for patients for whom #GastroPsych tx is prescribed (2/2) https://t.co/lSu4dudv0w

Nov 10, 2022 · 6 likes · 2 shares · 3,762 followers View post →
UBuffalo Social Work
@UBSSW · X

@SWcareer Here you go, Dorlee! The journal article: https://t.co/6oCCvYrvOh <Link includes a video abstract (1 min 50 sec)

Jul 20, 2022 · 6,997 followers View post →
Christina Tennyson MD
@TennysonMD · X

The Brain Gut Microbiome system is complex and we are just learning how these systems affect each other Paper by Jonathan Jacobs @emeranamayer on #CBT & brain gut #microbiome system #gastropsych https://t.co/8XV3hjoMS1

Mar 12, 2022 · 2 likes · 3,780 followers View post →
Samar Harris MD
@SamarHarris2 · X

RT @SultanMahmoodMD: Fascinating study by my colleague @Jeff_Lackner and colleagues showing that patients responding to CBT had different g…

Jan 12, 2022 · 2 shares · 265 followers View post →
Gastro RTs
@GastroRTs · X

RT @SultanMahmoodMD: Fascinating study by my colleague @Jeff_Lackner and colleagues showing that patients responding to CBT had different g…

Jan 11, 2022 · 2 shares · 2,002 followers View post →
Sultan Mahmood MD
@SultanMahmoodMD · X

Fascinating study by my colleague @Jeff_Lackner and colleagues showing that patients responding to CBT had different gut microbiome than non responders. There is co-correlated shifts in brain networks and gut microbiome with CBT #gitwitter

Jan 11, 2022 · 12 likes · 2 shares · 7,047 followers View post →
Kailas Roberts
@yourbraininmind · X

Fascinating research on the two way relationship between our microbiome and our brains. Here the focus is on using cognitive behavioural therapy to treat Irritable Bowel Syndrome, with evidence that our microbiome may influence res…https://t.co/FuxUNIa3YO https://t.co/X1HU0sqTu3

Jan 10, 2022 · 2 likes · 100 followers View post →
SEMiPYP
@SEMiPYP · X

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement by J. P. Jacobs et al. ⤵️ https://t.co/el4J4YVsQQ Microbiome @BioMedCentral #microbiota #IBS #CBT https://t.co/aoG9G17DGf

Dec 16, 2021 · 3 likes · 1 share · 1,589 followers View post →
Kim Kulp, RD
@KimKulpRD · X

RT @john_damianosMD: Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 8, 2021 · 6 shares · 47 followers View post →
Javier Alcedo
@alcedo_javier · X

RT @john_damianosMD: Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 8, 2021 · 6 shares · 540 followers View post →
Isabel Pérez García
@isaNutrisalud · X

RT @john_damianosMD: Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 7, 2021 · 6 shares · 3,675 followers View post →
Kate Scarlata, MPH, RDN
@KateScarlata_RD · X

RT @john_damianosMD: Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 7, 2021 · 6 shares · 12,455 followers View post →
Gastro RTs
@GastroRTs · X

RT @john_damianosMD: Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 7, 2021 · 6 shares · 2,002 followers View post →
John Damianos, M.D.
@john_damianosMD · X

Cognitive behavioral therapy is effective for #IBS. Here’s what’s cool:

Dec 7, 2021 · 13 likes · 6 shares · 24,036 followers View post →
Rebecca Winderman, MD | KidsGastroDoc
@kidsgastrodoc · X

Study shows: Gut microbiota & serotonin levels are associated with response to Cognitive Behavioral Therapy (CBT) in patients with Irritable Bowel Syndrome https://t.co/KE8OTrROng

Dec 6, 2021 · 6 likes · 18,969 followers View post →
Ravi R. Bhatt
@ravirbot · X

How can potential therapies change the body to help relieve symptoms in IBS? We show that CBT shifts the brain-gut-microbiome axis in people who show symptom improvement. @emeranamayer @AGuptaCNS https://t.co/xYwd5saItO

Dec 2, 2021 · 4 likes · 207 followers View post →
Stella S.
@stellasevp · X

RT @emeranamayer: In 2016, we were the first to show that the ingestion of a #probiotic cocktail can alter brain function in healthy young…

Dec 1, 2021 · 1 share · 33 followers View post →
Symbiosis papers
@Symbiosispapers · X

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement https://t.co/j4SVkKJsjN

Dec 1, 2021 · 1,107 followers View post →
Emeran Mayer, MD
@EmeranMayerMD · X

In 2016, we were the first to show that the ingestion of a #probiotic cocktail can alter brain function in healthy young women. We now show that normalizing brain function in patients with #IBS by CBT can influence the #gutmicrobiome. Check it out at https://t.co/UMy656A1eT

Dec 1, 2021 · 12 likes · 1 share · 4,452 followers View post →
给你中
@wzx_7926 · X

RT @MicrobiomeJ: Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome ax…

Nov 30, 2021 · 8 shares · 79 followers View post →
UCLA Gastroenterology and Hepatology
@UCLAGIHep · X

RT @AGuptaCNS: We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner…

Nov 30, 2021 · 4 shares · 1,551 followers View post →
Carina Carbia
@carinacarbiaC · X

RT @AGuptaCNS: We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner…

Nov 30, 2021 · 4 shares · 423 followers View post →
Jeff Lackner
@Jeff_Lackner · X

RT @AGuptaCNS: We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner…

Nov 30, 2021 · 4 shares · 125 followers View post →
David Campos
@David_camposma · X

RT @MicrobiomeJ: Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome ax…

Nov 30, 2021 · 8 shares · 119 followers View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @MicrobiomeJ: Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome ax…

Nov 30, 2021 · 8 shares · 3,526 followers View post →
Geoffroy Mallaret
@MallaretG · X

RT @MicrobiomeJ: Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome ax…

Nov 30, 2021 · 8 shares · 621 followers View post →
Microbiome
@MicrobiomeJ · X

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement https://t.co/9GiSD490Q3

Nov 30, 2021 · 14 likes · 8 shares · 20,469 followers View post →
Ravi R. Bhatt
@ravirbot · X

RT @AGuptaCNS: We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner…

Nov 30, 2021 · 4 shares · 207 followers View post →
Arpana Church
@ArpanaChurch · X

We see significant shifts in #braingutmicrobiome after #CBT in #IBS patients @emeranamayer @ravirbot @LabusJS @Jeff_Lackner #UCLAGI @UCLAHealth https://t.co/NsMQPmzNYc

Nov 30, 2021 · 7 likes · 4 shares · 789 followers View post →
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