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November 2022 PMID 34848313

Impact of colloids or crystalloids in renal function assessed by NGAL and KIM-1 after hysterectomy: randomized controlled trial.

Murillo G Santos, João Paulo Jordão Pontes, Saulo Gonçalves Filho, Rodrigo M Lima, Murilo M Thom, Norma Sueli P Módolo, Daniela Ponce, Lais Helena Navarro

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Abstract in brief

  • This study compared the effects of Hydroxyethyl starch (HES) and Ringers lactate (RL) during hysterectomy, focusing on kidney health using biomarkers like NGAL and KIM1, and found no significant difference in these markers between the two groups, indicating similar renal safety.
  • Patients receiving RL used more fluid and experienced more fluid overload compared to those given HES, which needed less volume to maintain blood pressure and was associated with less fluid retention post-surgery.
  • Overall, HES appeared to be effective in maintaining stable kidney function and better fluid management during surgery without increasing kidney injury markers.]
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