Posts frequently discuss how heterologous infection and vaccination influence immune responses, using words like 'shapes immunity' and 'protection', and referencing scientific terms such as immune imprinting and neutralizing antibodies. The tone is analytical and optimistic about evolving vaccine strategies, which supports the overall score of high interest and engagement with a sense of meaningful impact.
AgreementModerate agreement
Most discussions acknowledge the significance of the study and support its conclusions about heterologous immunity and immune imprinting effects.
InterestHigh interest
The majority of posts show high curiosity, often referencing specific mechanisms like immune imprinting and neutralizing antibodies, indicating strong engagement with the topic.
EngagementHigh engagement
Many posters delve into detailed interpretations, referencing external experts, explaining concepts, and sharing links, reflecting deep involvement.
ImpactModerate impact
The discussions highlight the potential implications for vaccine strategies and understanding immunity, suggesting a moderate to high perceived impact.
Abstract in brief
The study found that after three exposures to the virus (infection plus two vaccines), certain immune responses like antibody memory B cells and neutralization of some variants plateaus, while others like B117 neutralization and T cell responses increase.
Serology tests based on the original Wuhan strain poorly predict how well immunity protects against different variants of concern (VOCs), indicating that vaccines may need to be tailored to new strains.
The effectiveness of neutralizing variants changed over time and depended on the specific virus encounters, suggesting that different combinations of infection and vaccination influence cross-protection, which is important for developing future vaccines.]
This video explores how multiple exposures to SARS-CoV-2, through infection and vaccination, shape immune responses, including antibody memory and T cell activity. It highlights the need for vaccine updates to protect…
This video explains the mechanism of immune imprinting, or original antigenic sin, and its implications for SARS-CoV-2 immunity, highlighting how previous infections and vaccinations influence immune responses and…
Jun 22, 2023 · 9 shares · 724 followersView post →
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石上千人"
@LIMwh1KzAuoq5A5 · X
RT @a_kruschke: @CiscoRucinski The other problems that emerged with omicron is immune imprinting. Nowadays, the meaning became a negative c…
Jun 16, 2023 · 2 shares · 168 followersView post →
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ptr12343
@ptr12343 · X
RT @a_kruschke: @CiscoRucinski The other problems that emerged with omicron is immune imprinting. Nowadays, the meaning became a negative c…
Jun 16, 2023 · 2 shares · 1,014 followersView post →
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A.Kruschke
@a_kruschke · X
@CiscoRucinski The other problems that emerged with omicron is immune imprinting. Nowadays, the meaning became a negative connotation, but it's a normal and important skill of our immune system.
I like Dr.Beens explanation very much, starts at 0:11:00.
https://t.co/uwcTJqPIXQ
Jun 16, 2023 · 6 likes · 2 shares · 1,490 followersView post →
@Marc_Veld @jwitker @BennyisHere_215 @BallouxFrancois It does appear to potentially offer differing immunity - based on sequence and variants infected with.
https://t.co/P3F0Wb7OO9
Jan 28, 2023 · 1 like · 1,048 followersView post →
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Ricardo Cannolini
@VersatiIeTwink · X
@nioldelapi @reflectfirst @0bj3ctivity @Marc_Veld "fails to develop a response specific to further variants" is total nonsense btw! There is plenty of response to new variants
https://t.co/RN2D2p6ooe
https://t.co/eJOWO5agQj
https://t.co/PaJWyv21Gf
etc etc. 'Imprinting' isnt the bad thing you think it is!
RT @keyaki1117: 「抗原原罪」(OAS)と新型コロナウイルスワクチン効果に関する最近の論文はこれ
①
https://t.co/7b8sPuGzpX
②
https://t.co/B3lTyI22GR
③
https://t.co/wEdumvRaX6
④
ht…
Dec 3, 2022 · 7 shares · 17,261 followersView post →
笹
笹山登生
@keyaki1117 · X
「抗原原罪」(OAS)と新型コロナウイルスワクチン効果に関する最近の論文はこれ
①
https://t.co/7b8sPuGzpX
②
https://t.co/B3lTyI22GR
③
https://t.co/wEdumvRaX6
④
https://t.co/fljM0r0dF4
⑤
https://t.co/YxE1j0xyfF
⑥
https://t.co/nSzMP4zExQ
その他
https://t.co/UhbWXBejfB
Dec 3, 2022 · 6 likes · 7 shares · 28,831 followersView post →
Oct 28, 2022 · 7 shares · 990 followersView post →
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ohagi
@fgidf98fj9jh0h · X
抗原原罪の仕組み解説動画
概要欄に論文が一杯
https://t.co/mRCf0yrdGi
Oct 28, 2022 · 14 likes · 7 shares · 4,622 followersView post →
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Paul Koshy
@paulkosh · X
@N_Shirtcliffe @VelaSoccer @_Pav__ @DrAseemMalhotra Immune imprinting effect of the spike protein shown in the reinfection Ab response to different variants in those prior infected and vaccinated? Unfortunately they did not look at reinfection Ab response in the unvaccinated. https://t.co/gtwDoaXeaJ 6/x
@davidzweig Does that imply the certain person in the vaccinated group don’t benefit from natural immunity so well? Why is that? Immune imprinting as per research published in Science: https://t.co/gtwDoaXeaJ
Oct 23, 2022 · 1 like · 1,209 followersView post →
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QuestionAll
@BreakingNewsFi2 · X
@pixelmountain @ModernDarkAge @_mbdr_ @lisa_iannattone Yes of course.
Immune imprinting results from exposure to proteins like the SARS-CoV-2 spike protein, that allow a virus to penetrate host cells and cause infection
https://t.co/C79jzRIuve
https://t.co/MwPfVrqaRh https://t.co/466DQRL3tO
Many ppl. and vaxxed ppl. are vexed that vaxxed ppl. are getting infected many Xs, but this has been researched and proven. Of course MSM who earn pHARMa $ will not report on "imprinting": https://t.co/TPPptuE7lj. Dr. Mobeen has a more graphic lecture: https://t.co/TCAfuR09EY.
@AdithyaR_YXE @AndrewNoymer It could be due to immunity imprinting as discussed in the following papers: 1) https://t.co/ZgH090AKar 2) https://t.co/r2ntHTCRlZ 3) https://t.co/3fh0c32e6w 4) https://t.co/f08Qid4GpL
@MartyMakary @Sensible__Med We do know quite a bit:
https://t.co/aXgO23Ecl0
https://t.co/litDp7YqVt
https://t.co/txYZsbnhFK
https://t.co/7uv4P8GCI6
https://t.co/bIFfhwnHlg
The thing is that the population has been exposed generally in different ways already. THAT's the group we are vaccinating.
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/tUrO3CbUaU La sombra del pecado antigénico en la revacunacion frente al SARS-CoV-2
Here's the PMID for that previous paper.. I'm stunned this stuff gets into Science. PMID: 34855510
Science 2022 Jan 14;375(6577):183-192. doi: 10.1126/science.abm0811.
Jun 15, 2022 · 14 likes · 23,132 followersView post →
How much longer will vaccines keep us safe?!??
⚠️My viral immunology is rusty (never was that good tbh) but this study seems a valuable entrypoint to that important Q:
Heterologous infection and vaccination shapes immunity against #coronavirus variants https://t.co/wHzVQgmEfE
@gadboit @juli_bg_bs Haven't read the paper in full (likely won't have the time to either..). Buf sounds like should be read, and interpreted, alongisde this other one?
https://t.co/OVCTFaAzRI
@mareksvejda @BaroneTereza Teď se ztrácím, co navrhujete. Pokud to, že se může očkovat stále stejnou variantou, tak souhlas. Vakcína proti alfě a betě by byla proti deltě horší než původní. Také nový článek ukazuje, že heterologní booster má nižší imunogenicitu než třikrát stejný. https://t.co/b4HCRdKJHE
La mutació de l'espiga N501Y, que es troba en moltes variants, sembla induir el factor regulador de transcripció de cèl·lules T FOXP3, cosa que indica que el virus podria subvertir la funció efectiva de les cèl·lules T.
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/IhbV2lX9ru
Jan 14, 2022 · 3 likes · 1 share · 2,894 followersView post →
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jorgenponder — om coronavirusepidemin
@jorgenponder · X
Mutationen N501Y som finns i Alfa, Beta och Gamma, verkar kunna ställa till det med T-cellsförsvaret.
https://t.co/XweGD5Mw48
https://t.co/eO6CydlkNy
https://t.co/wS6aGajHz7 https://t.co/rRON1nT0CB https://t.co/LLEUSH9eyV
Jan 14, 2022 · 3 likes · 2,786 followersView post →
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Dr.med. Bernd Kynast
@DrKynast · X
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/UDhiaiKqnd
RT @EngEongOoi: Different variant infections carry distinct immune memory, with implications for protection against future VOCs. @ScienceMa…
Jan 13, 2022 · 7 shares · 389 followersView post →
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Rajeev
@Rajeev_The_King · X
RT @EngEongOoi: Different variant infections carry distinct immune memory, with implications for protection against future VOCs. @ScienceMa…
Jan 13, 2022 · 7 shares · 4,025 followersView post →
EO
Eng Eong Ooi
@EngEongOoi · X
Different variant infections carry distinct immune memory, with implications for protection against future VOCs. @ScienceMagazine
https://t.co/Qg2PVw6gSW
Jan 13, 2022 · 9 likes · 7 shares · 1,814 followersView post →
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Oggy
@OgiliusOggy · X
Dla ozdrowieńców, o tym jak wariant którym się zarazili (pierwszy kontakt) determinuje późniejszą charakterystykę odporności na inne. Dalsze szczepienia wydają się tylko podkręcać efekt
https://t.co/ArJfCMq9aR https://t.co/cc3S8j8dhu
@RWMaloneMD @rubic3n Because of pre-immunity, which is heterologous, from a virus causing heterologous infections “Dr.” ?! https://t.co/qOyP3aGidb https://t.co/xo180echBb
Dec 26, 2021 · 1 like · 1 share · 315 followersView post →
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alibaba
@alibaba76335244 · X
RT @BoytonRosemary: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/mhX5XKLHVb. Note that m…
Dec 22, 2021 · 5 shares · 559 followersView post →
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strummaster42
@strummaster42 · X
@AllOne77777 https://t.co/vrbkUsNSBU
Dec 15, 2021 · 1 like · 21,786 followersView post →
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Lucia Ruggiero EALR
@luciaruggiero · X
RT @equityhealthdev: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t…
Dec 14, 2021 · 1 share · 1,025 followersView post →
EH
Equity and Health
@equityhealthdev · X
RT @GlobalPHObserv: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
https://t.co/uZuufTj5ad
Dec 14, 2021 · 3 shares · 3,449 followersView post →
EH
Equity and Health
@equityhealthdev · X
Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co/92gB7age46
Dec 14, 2021 · 2 likes · 1 share · 3,449 followersView post →
CE
Culture of Health Eq
@CofHEQ · X
RT @GlobalPHObserv: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
https://t.co/uZuufTj5ad
Dec 14, 2021 · 3 shares · 1,090 followersView post →
CE
Culture of Health Eq
@CofHEQ · X
Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co/tklPZfdY9o
RT @BoytonRosemary: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/mhX5XKLHVb. Note that m…
Dec 14, 2021 · 5 shares · 571 followersView post →
DC
Dominic Cummings
@Dominic2306 · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 312,216 followersView post →
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ViralPseudotypeUnit
@ViralPseudotype · X
RT @BoytonRosemary: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/mhX5XKLHVb. Note that m…
Dec 14, 2021 · 5 shares · 2,055 followersView post →
SB
Stephen Ball
@sball_endo · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 1,808 followersView post →
KG
kārlis gertmanis
@karlisgertmanis · X
RT @BoytonRosemary: Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/mhX5XKLHVb. Note that m…
Dec 14, 2021 · 5 shares · 387 followersView post →
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RosemaryBoyton
@BoytonRosemary · X
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/5ejkAVzNYP. After 3 homologous spike antigen encounters S1 RBD Ab, memory B cell frequency and nAbs against heterologous beta, gamma and delta plateau, T cell responses increase.
Dec 14, 2021 · 4 likes · 1 share · 571 followersView post →
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Brian Leung
@bleung_tri · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 256 followersView post →
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RosemaryBoyton
@BoytonRosemary · X
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/mhX5XKLHVb. Note that majority of 2 dose vaccinated infection naive have no detectable nAb against delta 21 weeks after 2nd dose, but memory B cells sustained.
Dec 14, 2021 · 11 likes · 5 shares · 571 followersView post →
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RosemaryBoyton
@BoytonRosemary · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 571 followersView post →
GO
Global Health Observ
@GlobalPHObserv · X
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
https://t.co/uZuufTj5ad
Dec 14, 2021 · 2 likes · 3 shares · 6,554 followersView post →
GO
Global Health Observ
@GlobalPHObserv · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 6,554 followersView post →
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ViralPseudotypeUnit
@ViralPseudotype · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 2,055 followersView post →
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e
@wkwtch · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 49 followersView post →
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Chris Thorpe
@jaggeree · X
RT @JeremyFarrar: Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co…
Dec 14, 2021 · 11 shares · 4,771 followersView post →
JF
Jeremy Farrar
@JeremyFarrar · X
Important science & underlines why we need to understand immunity before we chase variant specific vaccines https://t.co/7bO7wYGMdJ
Dec 14, 2021 · 50 likes · 11 shares · 75,945 followersView post →
VC
Vincenzo Cersosimo
@v_cersosimo · X
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/hcnJY7WwrY #COVID19
RT @chngin_the_wrld: Today's #shoutout to #womenInSTEM goes to Catherine Reynolds & @BoytonRosemary for their cool @ScienceMagazine paper s…
Dec 10, 2021 · 2 shares · 789 followersView post →
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RosemaryBoyton
@BoytonRosemary · X
RT @chngin_the_wrld: Today's #shoutout to #womenInSTEM goes to Catherine Reynolds & @BoytonRosemary for their cool @ScienceMagazine paper s…
Dec 10, 2021 · 2 shares · 571 followersView post →
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Steffanie Strathdee, PhD
@chngin_the_wrld · X
Today's #shoutout to #womenInSTEM goes to Catherine Reynolds & @BoytonRosemary for their cool @ScienceMagazine paper showing that "immune imprinting" by #infection & #COVID19vaccines causes varied patterns of protection against #COVID19 variants.
https://t.co/WFVZMD5onz
Dec 10, 2021 · 6 likes · 2 shares · 22,016 followersView post →
Incredible work by Catherine Reynolds, rounding out a fantastic year of publications. Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants https://t.co/RSudk1hlgp