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Front Cell Neurosci November 2021 PMID 34867206

Activation of Adenosine Monophosphate-Activated Protein Kinase Drives the Aerobic Glycolysis in Hippocampus for Delaying Cognitive Decline Following Electroacupuncture Treatment in APP/PS1 Mice.

Jianhong Li, Bingxue Zhang, Weiwei Jia, Minguang Yang, Yuhao Zhang, Jiayong Zhang, Le Li, Tingting Jin, Zhifu Wang, Jing Tao, Lidian Chen, Shengxiang Liang, Weilin Liu

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Mentions

4
Peak: 1 in Nov 2021
across 2 sources since Nov 2021

Extended reach

81,995
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Total likes

33

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1,218

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Nov 2021 – Oct 2024

Where it's discussed

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AI synopsis

What people are saying

Discussions highlight the importance of AMPK and aerobic glycolysis in brain health, with some posts praising the potential for EA to delay cognitive decline in Alzheimer's models. The tone reflects curiosity mixed with cautious support, focusing on how this research could inform future therapies.

AgreementModerate agreement

Most comments acknowledge the significance of the research, with some expressing support for the findings about EA's benefits.

InterestModerate interest

Discussions indicate moderate curiosity, with mentions of mechanisms like AMPK activation and potential implications for Alzheimer's therapy.

EngagementModerate engagement

Participants seem to show a reasonable level of interest by referencing cellular processes and potential clinical impact, but do not deeply critique or question the study.

ImpactModerate impact

The discussion recognizes the potential influence of the research on understanding neurodegeneration and treatment approaches, although the overall tone suggests cautious optimism.

Abstract in brief

  • Electroacupuncture (EA) improves cognitive functions in APPPS1 mice by increasing glucose metabolism in the hippocampus, which is usually decreased in Alzheimer's disease.
  • The activation of AMPK (a key energy regulator) by EA promotes aerobic glycolysis (AG), boosting energy production and supporting brain health; this process is linked to improved learning and memory in the mice.
  • Disabling AMPK reduces the beneficial effects of EA on AG and cognition, confirming that EA works mainly through activating AMPK to enhance energy metabolism and delay cognitive decline in early-stage Alzheimer's.]
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Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Activation of Adenosine Monophosphate-Activated Protein Kinase Drives the Aerobic Glycolysis in Hippocampus for Delaying Cognitive Decline Following Electroacupuncture Treatment in APP/PS1 Mice: Aerobic glycolysis (AG), an… https://t.co/Mm55jjdJ0r #neuroscience

Nov 29, 2021 · 5 likes · 80,778 followers View post →

All mentions

Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Activation of Adenosine Monophosphate-Activated Protein Kinase Drives the Aerobic Glycolysis in Hippocampus for Delaying Cognitive Decline Following Electroacupuncture Treatment in APP/PS1 Mice: Aerobic glycolysis (AG), an… https://t.co/Mm55jjdJ0r #neuroscience

Nov 29, 2021 · 5 likes · 80,778 followers View post →