BMC Infect Dis December 2021 PMID 34872511

Safety and efficacy of hydroxychloroquine for treatment of non-severe COVID-19 among adults in Uganda: a randomized open label phase II clinical trial.

Pauline Byakika-Kibwika, Christine Sekaggya-Wiltshire, Jerome Roy Semakula, Jane Nakibuuka, Joseph Musaazi, James Kayima, Cornelius Sendagire, David Meya, Bruce Kirenga, Sarah Nanzigu, Arthur Kwizera, Fred Nakwagala, Ivan Kisuule, Misaki Wayengera, Henry G Mwebesa

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Mentions

21
Peak: 3 in Dec 2021
across 2 sources since Jun 2021

Extended reach

52,511
potential audience

Total likes

1,924

Video views

42,974

Mentions per month

Jun 2021 – Jun 2024

Where it's discussed

  • X / Twitter19 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions strongly agree with the study's conclusion that hydroxychloroquine is ineffective against COVID-19, exemplified by clear statements like 'HCQ ne marche pas contre le Covid' and references to recent clinical trials. Words like 'confirme', 'publié', and commands such as 'INSTRUISEZ VOUS!' indicate both agreement and a call for scientifically informed debate, showing high engagement and recognition of the study's importance.

AgreementStrong agreement

Most discussions emphasize that the study confirms hydroxychloroquine's ineffectiveness for COVID-19, with some posts explicitly stating 'hydroxychloroquine doesn’t work' and referencing the study to support this claim.

InterestModerate interest

Posts demonstrate a moderate level of interest, with some users sharing specific study results and mentioning clinical trials, but many focus on reaffirming known findings rather than exploring new implications.

EngagementHigh engagement

Several posters engage deeply by citing detailed trial results, referencing multiple studies, and calling for scientific literacy like 'INSTRUISEZ VOUS!', which indicates a serious dive into the research context.

ImpactHigh impact

The discussions reflect significant impact, with some posts linking these findings to broader debates and policy choices, highlighting the ongoing relevance of the study in guiding public health decisions.

Abstract in brief

  • The study investigated whether hydroxychloroquine (HCQ) helps treat nonsevere COVID-19 in adults in Uganda and found no significant difference in viral clearance or symptom relief between those treated with HCQ plus standard care and those with standard care alone.
  • This was a Phase II randomized clinical trial with 105 participants, where viral load was measured over 10 days, but HCQ did not improve the speed of viral clearance compared to standard treatment.
  • The results suggest that HCQ is not effective in reducing the duration of viral presence or improving symptoms in mild COVID-19 cases, aligning with other conflicting or negative findings from prior studies.

Top posts

Most liked on X and Bluesky
Vetgerval
@GValeau · X

@rosewood2019 @chalumo @Ikonut1 @AnotherGenro @VeritasNobis @BonSens47865369 @achilledamu @JohnAlfredMorg1 @AlizeeRenault @Odieux_Vulgaire @Bravehawkspiri1 @SebastienAeko @OPECST_ @LeseulG @SoniadlpCaen @flolassarade @VillaniCedric @gerardlonguet55 @AssembleeNat @Senat @BanounHelene Meuf tu es dans le déni. C'est pas Recovery. L'HCQ ne marche pas contre le Covid. https://t.co/HbwoUPf3kA https://t.co/MKj2X0Uscr https://t.co/Sqow7h2PcD https://t.co/In9xGcvyRi https://t.co/boKV5BIkux https://t.co/aTVR1SnLdD

Aug 5, 2022 · 2 likes · 1,104 followers View post →
Vetgerval
@GValeau · X

@rosewood2019 @chalumo @AnotherGenro @VeritasNobis @Ikonut1 @BonSens47865369 @achilledamu @JohnAlfredMorg1 @AlizeeRenault @Odieux_Vulgaire @Bravehawkspiri1 @SebastienAeko @OPECST_ @LeseulG @SoniadlpCaen @flolassarade @VillaniCedric @gerardlonguet55 @AssembleeNat @Senat @BanounHelene Essai clinique publié en décembre 2021 : L'hydroxychloroquine ne soigne pas le Covid et ne diminue pas la charge viral en SARS-COV-2. https://t.co/HbwoUPf3kA

Aug 4, 2022 · 2 likes · 1,104 followers View post →
Pharmacare | Ziverdo Kits
@Pharmacarestore · X

Safety and Efficacy of #Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in #Uganda :#RhodeIsland #SouthCarolina #SouthDakota #Tennessee #Texas #Utah #UnitedStates #MidGlamorgan #Monmouthshire #Montgomeryshire #Pembrokeshire #Powys https://t.co/G1fKYvvKxC

Sep 18, 2021 · 1 like · 1 share · 512 followers View post →
Alex
@alexxcani · X

@PeteyToolbag @JohnnieKnuckles @FlorioGina but, just in case you do want links: 06 dec 21 - clinical trial https://t.co/LRVuEzFjzN 01 oct 21 - review of clinical trials https://t.co/CV1OpOoSlf 15 apr 21 - collaborative analysis of trials https://t.co/pi7AMo4HNo feb 21 - survey https://t.co/2eWWzJ9OYZ

Jan 3, 2022 · 1 like · 55 followers View post →
Vetgerval
@GValeau · X

@VoltageBad @SpcialTK1 @decoder_l @amine_umlil L'hydroxychloroquine ne soigne pas le Covid, ni en préventif ni en curatif, et au contraire augmente la mortalité du Covid https://t.co/kEooa57p4Q https://t.co/8eNE1L8RlY https://t.co/lyp4GcS69t https://t.co/HbwoUPf3kA https://t.co/MKj2X0Uscr

Feb 5, 2023 · 1,104 followers View post →
Vetgerval
@GValeau · X

@JYGATEAU @DIVIZIO1 @ben_joda @raoult_didier Un article tout chaud, publié aujourd'hui même. Essai randomisé de l'HCQ vs placebo: ça marche pas, l'HCQ ne sert à rien et n'est pas recommandée dans le traitement du Covid-19 Ne regardez pas BFM, regarder les études https://t.co/sZXEiaqm1m

Dec 7, 2021 · 1,104 followers View post →

All mentions

Colin O'Scopie
@Colin_O_Scopie · X

@SilverFoxBid1 @thejackhopkins Just gonna drop this here https://t.co/Phh7lPfDae "Our results show that HCQ 400 mg twice a day for the first day followed by 200 mg twice daily for the next 4 days was safe but not associated with reduction in viral clearance or symptom resolution among adults with COVID-19."

Jun 4, 2024 · 98 followers View post →
Anubis
@sharpcoder28 · X

@jimmy_dore Hydroxychloroquine doesn’t work for COVID: https://t.co/TT2bAMCI7v https://t.co/7SyVf6rbex https://t.co/UB1k97tX1V https://t.co/S3C4KmDl4t

Jul 27, 2023 · 42 followers View post →
Vetgerval
@GValeau · X

@VoltageBad @SpcialTK1 @decoder_l @amine_umlil L'hydroxychloroquine ne soigne pas le Covid, ni en préventif ni en curatif, et au contraire augmente la mortalité du Covid https://t.co/kEooa57p4Q https://t.co/8eNE1L8RlY https://t.co/lyp4GcS69t https://t.co/HbwoUPf3kA https://t.co/MKj2X0Uscr

Feb 5, 2023 · 1,104 followers View post →
I like bagels
@Irlylikebagels · X

@Cristi_Neagu @Ellis_X5 @kylenabecker There's no blanket ban, all of those options were considered. There simply isn't enough evidence to justify their use. https://t.co/n37PaR6eW1 https://t.co/guO2ELbHrQ https://t.co/RagGIIJEeJ

Dec 21, 2022 · 58 followers View post →
The Cronk
@cronksciswag · X

@CanadianChris17 @scully21 @punk2650 @TheoFleury14 https://t.co/RZholCGCVC

Nov 1, 2022 · 607 followers View post →
Vetgerval
@GValeau · X

@rosewood2019 @chalumo @Ikonut1 @AnotherGenro @VeritasNobis @BonSens47865369 @achilledamu @JohnAlfredMorg1 @AlizeeRenault @Odieux_Vulgaire @Bravehawkspiri1 @SebastienAeko @OPECST_ @LeseulG @SoniadlpCaen @flolassarade @VillaniCedric @gerardlonguet55 @AssembleeNat @Senat @BanounHelene Meuf tu es dans le déni. C'est pas Recovery. L'HCQ ne marche pas contre le Covid. https://t.co/HbwoUPf3kA https://t.co/MKj2X0Uscr https://t.co/Sqow7h2PcD https://t.co/In9xGcvyRi https://t.co/boKV5BIkux https://t.co/aTVR1SnLdD

Aug 5, 2022 · 2 likes · 1,104 followers View post →
Vetgerval
@GValeau · X

@rosewood2019 @chalumo @AnotherGenro @VeritasNobis @Ikonut1 @BonSens47865369 @achilledamu @JohnAlfredMorg1 @AlizeeRenault @Odieux_Vulgaire @Bravehawkspiri1 @SebastienAeko @OPECST_ @LeseulG @SoniadlpCaen @flolassarade @VillaniCedric @gerardlonguet55 @AssembleeNat @Senat @BanounHelene Essai clinique publié en décembre 2021 : L'hydroxychloroquine ne soigne pas le Covid et ne diminue pas la charge viral en SARS-COV-2. https://t.co/HbwoUPf3kA

Aug 4, 2022 · 2 likes · 1,104 followers View post →
Jon Fleming
@JonRFleming · X

@dorthy_fromoz @GumbeauxMike @AngryFleas @FvckYourFear @RealDoctorT @digital_slime @ShadowDroid616 @Section_230 @John_iwas_ @Admone7 @MaRk_I8I @SouthernNight33 @JimlikesBB @drdeblk @TifasWindmill @EyeMMom @ArtysHouse @InfoGuru16 @RogerRa09234150 @f_kyburz @LaneMonsterTX @LentSjaak @NHSouthernGirl @modernista64 @CraigCastleber1 @SeptRose70 @Tom_Neverwinter @JustinM11151153 @Billenjoylife @Garrett_Archer @shafercw @StanPennington8 @kalymera1960 @deusxmach1na @Mattallica17 @Dan_Donovan_17 @SandraNotSandy1 @symmo1969 @NickDone8 @truthgibbon @suckitjackbootz @BobsDog4 @DrAcula987 @IainMulady @toolemond @Deborah68750856 @SwaledaleMutton @lilithsappetite @PootDibou https://t.co/4q8rARj9DN

Apr 18, 2022 · 946 followers View post →
Julie Scares Me
@jburr1017 · X

@bettyboop7499 @Janice59694287 @tuxlemons 2005? Here's a study, from your source, 12/2021. https://t.co/49X7c4AZOe

Feb 11, 2022 · 176 followers View post →
Degraf Hilda
@DegrafH · X

@Zenon71647295 @giranthon @Christi67158123 INSTRUISEZ VOUS! Etudes RANDOMISEES : 4 / 15 https://t.co/rnZk3Nw4R0 https://t.co/F2NZsyGJZV https://t.co/XuOaOG0eRZ https://t.co/MTNenD3saR

Feb 6, 2022 · 125 followers View post →
truc muche
@trucmuc28502451 · X

@Djeje23715520 @OSS117_Helsinki Ah oui, en Ouganda, il y a des résultats. HCQ marche pas https://t.co/zj7ZE30hDJ

Jan 6, 2022 · 157 followers View post →
SM
@concombre1312 · X

@millle40 @PascalGana @Guiguidemontpel @PKacew @PhilippeRainant @RobertMenardFR https://t.co/scXK4IL7is

Jan 5, 2022 · 15 followers View post →
Alex
@alexxcani · X

@PeteyToolbag @JohnnieKnuckles @FlorioGina but, just in case you do want links: 06 dec 21 - clinical trial https://t.co/LRVuEzFjzN 01 oct 21 - review of clinical trials https://t.co/CV1OpOoSlf 15 apr 21 - collaborative analysis of trials https://t.co/pi7AMo4HNo feb 21 - survey https://t.co/2eWWzJ9OYZ

Jan 3, 2022 · 1 like · 55 followers View post →
Meloar Freilhec
@MeloarFreilhec · X

Résultats d'un essai randomisé ouvert mené en Ouganda, de phase 2, publiée hier : aucune efficacité de l'hydroxychloroquine. https://t.co/cJZkiheBwc

Dec 7, 2021 · 525 followers View post →
Vetgerval
@GValeau · X

@LinetteElire @OuestFrance Certain ! Encore aujourd'hui un article scientifique confirme que l'Hydroxychloroquine ne soigne pas le covid-19. https://t.co/sZXEiaqm1m

Dec 7, 2021 · 1,104 followers View post →
Vetgerval
@GValeau · X

@JYGATEAU @DIVIZIO1 @ben_joda @raoult_didier Un article tout chaud, publié aujourd'hui même. Essai randomisé de l'HCQ vs placebo: ça marche pas, l'HCQ ne sert à rien et n'est pas recommandée dans le traitement du Covid-19 Ne regardez pas BFM, regarder les études https://t.co/sZXEiaqm1m

Dec 7, 2021 · 1,104 followers View post →
Antiviral Store | Cancer | HIV
@antiviral_med · X

RT @ivermectincovid: Safety and Efficacy of #Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in #Uganda :#RhodeIsland #S…

Sep 18, 2021 · 1 share · 60 followers View post →
Pharmacare | Ziverdo Kits
@Pharmacarestore · X

Safety and Efficacy of #Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in #Uganda :#RhodeIsland #SouthCarolina #SouthDakota #Tennessee #Texas #Utah #UnitedStates #MidGlamorgan #Monmouthshire #Montgomeryshire #Pembrokeshire #Powys https://t.co/G1fKYvvKxC

Sep 18, 2021 · 1 like · 1 share · 512 followers View post →
Research Square Covid-19 Preprints
@RS_COVID19 · X

Safety and Efficacy of Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in Uganda: A Randomized Open Label Phase II Clinical Trial #covid https://t.co/G57WRrDDN8

Jun 4, 2021 · 638 followers View post →