Intensive Care Med January 2022 PMID 34904190

Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial.

Gerald Matchett, Irina Gasanova, Christina A Riccio, Dawood Nasir, Mary C Sunna, Brian J Bravenec, Omaira Azizad, Brian Farrell, Abu Minhajuddin, Jesse W Stewart, Lawrence W Liang, Tiffany Sun Moon, Pamela E Fox, Callie G Ebeling, Miakka N Smith

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Mentions

211

Peak: 37 in Feb 2023

across 5 sources since Dec 2021

Extended reach

813,914

potential audience

Total likes

523

Video views

506

Mentions per month

Dec 2021 – Jul 2025

Where it's discussed

X / Twitter190 posts
Blogs9 articles
Facebook8 posts
Bluesky2 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions highlight key aspects of the publication, mentioning critical findings like the statistically significant Day 7 survival advantage of ketamine over etomidate (85.1% vs. 77.3%). Some participants express skepticism, questioning the relevance of the short-term mortality data or the necessity of etomidate in certain situations. Phrases such as 'clear signal of harm' reflect concern about etomidate's safety profile, while others noted the necessity of considering patient contexts. The tone shifts from supportive to questioning, illustrating a nuanced understanding of the implications of this study.

AgreementModerate agreement

Most discussions support the findings from the trial, leaning towards ketamine’s benefits.

InterestHigh interest

Participants express strong curiosity about the details and implications of the study.

EngagementModerate engagement

Many posts delve into study specifics, such as comparison arguments and clinical implications.

ImpactHigh impact

Users perceive the study to have significant implications for clinical practice in emergency medicine.

Abstract in brief

The study compares etomidate and ketamine as induction agents during emergency endotracheal intubation in critically ill patients, hypothesizing that ketamine would improve Day 7 survival.
A total of 801 patients were randomized to receive either etomidate or ketamine, with results indicating a significant survival advantage for the ketamine group at Day 7 (85.1% vs. 77.3%).
However, by Day 28, the survival rates were not significantly different between the two groups, suggesting the initial benefit of ketamine may not persist long-term.

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Etomidate vs. Ketamine: Outcomes in Emergency Intubation Study

This video presents the findings of a study comparing etomidate and ketamine as induction agents during emergency endotracheal intubation. Results show a significant survival advantage for ketamine at Day 7, but…

Arbo Educação · Jan 9, 2022 288 views

Sedation Techniques for Emergency Department Care

Contributor Travis Barlock MD explores common sedatives used in the Emergency Department, focusing on their benefits and downsides. Key agents include Propofol, known for quick action and reducing intracranial pressure…

Emergency Medical Minute · Nov 6, 2023 218 views

anup singh

@anupsinghahens · X

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Jul 30, 2025 · 140 shares · 28 followers View post →

ATS Crit Care

@ATSCritCare · X

Check out the Open Critical Care Grand Rounds Collective on the ATS Website (https://t.co/sdURWbAYwv) This month we are highlighting "Etomidate versus Ketamine for Emergency Endotracheal Intubation: A Randomized Clinical Trial (The EvK Trial)" (https://t.co/zbL5GmB7d0)

Mar 10, 2025 · 13,825 followers View post →

Brian Locke, MD MSCI

@doc_BLocke · X

@phlegmfighter @reverendofdoubt @DrToddLee I’m not opposed - but the biggest critique of the 1 RCT that used a short outcome (7d mortality) was ‘who cares if they survive the intubation if they die a few days later?’ - arguments both ways. https://t.co/sF6pKXcYsb

Feb 5, 2025 · 1,293 followers View post →

Dr. Jesus Pulido Barba

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Nov 23, 2023 · 43 shares · 1,081 followers View post →

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Nov 21, 2023 · 43 shares · 152 followers View post →

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Nov 21, 2023 · 43 shares · 113 followers View post →

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RECAT

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Nov 21, 2023 · 121 likes · 43 shares · 36,408 followers View post →

Louis Mullie, MD

@LouisMullie · X

@TupaEmondi @NoobieMatt @AnnalsofEM @mayoclinicemres @MayoPharmRes @TamingtheSRU Best meta-analysis = less hypotension with etomidate: https://t.co/0kJLYWgLCq But best RCT = less mortality with ketamine: https://t.co/gR7xImKfv9 Post-ETT hypotension is almost 99% preventable w/ aggressive pre/post vasopressors. Overshooting on BP is safe in most patients.

Jun 7, 2023 · 2 likes · 2,852 followers View post →

Brown EM Residency

@BrownEMRes · X

Mar 24, 2023 · 16 likes · 1 share · 4,420 followers View post →

Robert Foryś

@robert_md_ep · X

Keramine versus etomidate for intubation of septic patient https://t.co/EAPMeZjqqu

Mar 1, 2023 · 398 followers View post →

Pharm. Milano Gil Antonella

@Antito_mg · X