Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как то не очень. В принципе результат в сравнении с плацебо даже минимально наоборот. https://t.co/0xxIaTML5B https://t.co/k92ehGGnBB
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial.
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Dec 2021 – Jul 2025Where it's discussed
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What people are saying
The discussions surrounding the publication highlight a consensus on the ineffectiveness of omega-3 fatty acids in preventing depression, with several posts stating that omega-3 supplementation does not yield benefits or even slightly increases depression risk. Phrases like 'no advantage for Marine Omega-3 fatty acids' and emphatic conclusions such as 'they don’t prevent depression' illustrate frustration with the results and a shared concern for public perception of dietary supplements, emphasizing the need for clarity in health recommendations.
Many posts express strong disagreement with the findings, stating that omega-3s may actually increase the risk of depression.
There is a high level of curiosity regarding the implications of the study, as many users ask questions or seek more information.
While some posts analyze details of the study, the overall engagement seems more reactive rather than deeply analytical.
Users perceive the study's findings as having significant implications for public health and dietary recommendations.
Abstract in brief
- A study was conducted to assess the impact of long-term supplementation with marine omega-3 fatty acids on the incidence of depression among adults in a large randomized trial involving 18,353 participants.
- Results showed that omega-3 supplementation did not significantly reduce the risk of developing depression or improve mood scores compared to a placebo, despite measuring various outcomes over a median treatment duration of 5.3 years.
- The trial involved participants at risk for both incident and recurrent depression, but no significant interaction effects between omega-3 and vitamin D supplementation were observed.
Top posts
Most liked on X and BlueskyThose taking 840mg combined epa/dha in this RCT had significantly increased risk of depression or clinical symptoms of depression https://t.co/jDiZVlTQWt
Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent depression https://t.co/dR5cm5C9dT https://t.co/Ybrazlmfca
This huge trial suggests that omega-3 fatty acids do NOT prevent #depression. In fact, they increase the risk slightly. What's the next vitamin we should all take? https://t.co/u5owcyjlJC
@StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depression. Bottom line—they don't prevent depression. This study found that they might increase risk slightly. https://t.co/26YThwwvZo
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@ProfessorWhale @doctorsaluja @Drlipid @n3doc @nationallipid @society_eas @escardio @atherosociety Omacor (465 mg EPA + 375 mg DHA) significantly increased the risk of depression over ~5y in the large VITAL-DEP trial: https://t.co/DV2IbYOt5K EPA only (e.g. Vascepa) might be more beneficial: * Cognition: https://t.co/3nq8XM5gIw * Depression: https://t.co/7W9skwJnvv * CVD:
オメガ3脂肪酸(青魚とかに含まれてるやつね)は、一般人口においてはうつ病の予防にも気分の持ち上げにもあんまり効果ないかもねって研究 イワシ食べてメンタルにいいことした気分になってたんだけどなw https://t.co/hMN7U4aA0S
#CCNMResearch Check out CCNM-Boucher student, Christa Gavril’s summary on ‘Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores’. DOI: 10.1001/jama.2021.21187 https://t.co/26jYqHVGDB
@Prisca1964 @HeldinEU I found the journal article https://t.co/qS9M4iETKD Interestingly, they used a smaller EPA-DHA dose than the other study: marine omega-3 fatty acids (1 g/d of fish oil, incl 465 mg [EHA] and 375 mg [DHA]) Vs 700 mg EPA and 480 mg DHA daily (Edited text here for brevity)
RT @ChrisPalmerMD: @StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depress…
RT @ChrisPalmerMD: @StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depress…
RT @ChrisPalmerMD: @StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depress…
RT @ChrisPalmerMD: @StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depress…
RT @ChrisPalmerMD: @StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depress…
@StuartBird @OmegaQuant This is the largest and most rigorous trial of omega-3 fatty acids in the prevention of #depression. Bottom line—they don't prevent depression. This study found that they might increase risk slightly. https://t.co/26YThwwvZo
y el dolor estomacal del 35,2% frente al 35,1%. Estas observaciones no dan soporte al uso de suplementos de omega-3 en adultos para prevenir la depresión. https://t.co/6YJrN38RXd
The 3/18/2022 #JournalClub presented "Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial". The… https://t.co/zgvYZI0W2w https://t.co/EDtjBbqHEG
@NazeNus @ITGREENTEA เรื่องซึมเศร้ายังเถียงๆกันอยู่คับ มีงานวิจัยบางชิ้นดูเหมือน “อาจจะ” เพิ่มโอกาสเกิดซึมเศร้าได้เล็กน้อย แต่คงต้องตามดูข้อมูลต่อ Ref https://t.co/IhbdbFOtR7 https://t.co/Lb7uwA1W4D
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial – PubMed https://t.co/OKPTVZ6eSg
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial – PubMed https://t.co/dyGJiSF03v
RT @Kamil_Paprotny: Prewencyjna suplementacja omega 3 w postaci tranu nie zmniejszała ryzyka depresji u osób w wieku 50+ Co ciekawe, w gru…
RT @Kamil_Paprotny: Prewencyjna suplementacja omega 3 w postaci tranu nie zmniejszała ryzyka depresji u osób w wieku 50+ Co ciekawe, w gru…
Prewencyjna suplementacja omega 3 w postaci tranu nie zmniejszała ryzyka depresji u osób w wieku 50+ Co ciekawe, w grupie omega 3 w porównaniu do placebo częściej dochodziło do rozwoju depresji (651 vs 583 przypadki) https://t.co/Xi9QSijaD3
RT @theproof: Those taking 840mg combined epa/dha in this RCT had significantly increased risk of depression or clinical symptoms of depres…
Those taking 840mg combined epa/dha in this RCT had significantly increased risk of depression or clinical symptoms of depression https://t.co/jDiZVlTQWt
Attending #IM2022? Supplement your schedule with Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores, free from @JAMA_current https://t.co/hIDBSAkQ3r https://t.co/R9YgyOJucK
https://t.co/lTFSXloetl
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/uNIzBOXCDq via @JAMA_current part of @JAMANetwork Not recommended in depression!
RT @adipofat:
RT @bagin_vladimir: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/vZgTD…
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/vZgTD9EZnN via @JAMA_current part of @JAMANetwork
La prise de suppléments d’acides gras oméga-3 (huile de poisson) ne prévient pas les symptômes dépressifs dans la population générale. Essai randomisé et contrôlé contre placebo sur 18353 personnes. https://t.co/2dbC6SVvO4
Studie: 18 353 Erw > 50 J ohne Depressionen oder klinisch relevante depressive Symptome zu Beginn der Studie, Omega-3-Supplementierung im Vergleich zu Placebo führte zu gemischten Ergebnissen, wenn überhaupt vergrößerte sich das Risiko einer Depression. https://t.co/VW07la8wcd
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/5voezJBsRL a través de @JAMA_current part of @JAMANetwork
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically … https://t.co/Xs1Hs67ye4
RT @talischolar: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically … https…
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically … https://t.co/YAq9ULShee 海洋由来オメガ3脂肪酸サプリメントの長期投与によりプラセボと比較し、うつ病または抑うつ症状の発症リスクがわずかではあるがに有意に増加した。
RT @ChrisPalmerMD: This huge trial suggests that omega-3 fatty acids do NOT prevent #depression. In fact, they increase the risk slightly.…
RT @ChrisPalmerMD: This huge trial suggests that omega-3 fatty acids do NOT prevent #depression. In fact, they increase the risk slightly.…
RT @ChrisPalmerMD: This huge trial suggests that omega-3 fatty acids do NOT prevent #depression. In fact, they increase the risk slightly.…
This huge trial suggests that omega-3 fatty acids do NOT prevent #depression. In fact, they increase the risk slightly. What's the next vitamin we should all take? https://t.co/u5owcyjlJC
RT @syuichiao89: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/w8VRihr9…
EvidenceAlerts | Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial. https://t.co/En5qDCGyet
JAMA Study: Omega-3 supplements yield no benefit for mental health outcomes among older adults https://t.co/AzIb54TL0Y
#論文紹介 JAMAの論文でω3脂肪酸の摂取がうつ病を予防するか調べた18000人の大規模RCT 結果はNSで、ω3でうつ病の予防は難しそうです。介入期間が5.3年と長く、人数も多いことから、どこまでちゃんとコントロールできているんだろうというのは引っかかりました。 https://t.co/O6CUyMaEqg
RT @CGMMaher: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/MwfgGLiUIL…
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/MwfgGLiUIL via @JAMA_current part of @JAMANetwork
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
@nick_krontiris Access the paywalled article from your library: https://t.co/AdzoiVIiMf Promote scholarly access to content by simply adding https://t.co/SXSePSX5De to the DOI URL
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial https://t.co/EfFdvtxR4p #nutrition #diet #supplements #supplement
RT @brunovellas: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevan…
RT @NanciGuestRDPhD:
RT @gavery10: No advantage for Marine Omega-3 fatty acids for #depression So let’s stop using oil from #Antarctic #Krill! Krill is essenti…
No advantage for Marine Omega-3 fatty acids for #depression So let’s stop using oil from #Antarctic #Krill! Krill is essential to much of life and close to the base of the world’s food chain. https://t.co/5cjlJxH9gT
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
RT @john_damianosMD: Omega-3 fatty acid supplementation was found not to prevent depression. #medtwitter #medicine #psychiatry #diet #nut…
RT @NanciGuestRDPhD:
RT @NanciGuestRDPhD:
https://t.co/tb0ggOihLn
RT @john_damianosMD: Omega-3 fatty acid supplementation was found not to prevent depression. #medtwitter #medicine #psychiatry #diet #nut…
RT @john_damianosMD: Omega-3 fatty acid supplementation was found not to prevent depression. #medtwitter #medicine #psychiatry #diet #nut…
RT @JulioBasulto_DN: Más pruebas de que "natural" no significa "inocuo". Suplementar con omega-3 en mayores de 50 años sin síntomas depres…
RT @Luke_629: Effect of Long-term Supplementation With Marine #Omega3 Fatty Acids vs Placebo on Risk of #Depression or Clinically Relevant…
Effect of Long-term Supplementation With Marine #Omega3 Fatty Acids vs Placebo on Risk of #Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial https://t.co/A3BAibBNTZ
RT @john_damianosMD: Omega-3 fatty acid supplementation was found not to prevent depression. #medtwitter #medicine #psychiatry #diet #nut…
Omega-3 fatty acid supplementation was found not to prevent depression. #medtwitter #medicine #psychiatry #diet #nutrition #mentalhealth https://t.co/2PLmj83swc
RT @NeuroscienceNew: “Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Re…
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/w8VRihr9l0 @JAMA_current part of @JAMANetworkより
RT @Prof_NickTalley: Fish oil or vitamin D for depression? Unfortunately evidence of no benefit. Effect of Long-term Supplementation With M…
RT @Prof_NickTalley: Fish oil or vitamin D for depression? Unfortunately evidence of no benefit. Effect of Long-term Supplementation With M…
RT @Prof_NickTalley: Fish oil or vitamin D for depression? Unfortunately evidence of no benefit. Effect of Long-term Supplementation With M…
Fish oil supplementation does not help prevent depression or boost mood. Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression and on Change in Mood Scores - A Randomized Clinical Trial doi:10.1001/jama.2021.21187
RT @NeuroscienceNew: “Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Re…
✅19K men & women over the age of 50 ✅Randomized to Omega-supplements or placebo for 5 yrs ✅Result: Omega -3 increase depression events by 13%! (1.13, CI,1.01-1.26; P = .03)
New article: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial https://t.co/4iWxWg4LgV #gastriccancer #oncology https://t.co/VhFs1IHFdA
Fish oil or vitamin D for depression? Unfortunately evidence of no benefit. Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression https://t.co/wpvZrYQBxS via @JAMA_current part of @JAMANetwork
RT @brunovellas: Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevan…
RT @A_Ra_Berlin: Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как т…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @NeuroscienceNew: “Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Re…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @NeuroscienceNew: “Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Re…
RT @NeuroscienceNew: “Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Re…
“Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores” by Olivia I. Okereke et al. JAMA https://t.co/r5Wy1ZOx4l
@michelnivard does this conclusion sounds familiar to a previous MR study? https://t.co/3pb9ZPpmFl
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA | https://t.co/2SmPquxcQO
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @A_Ra_Berlin: Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как т…
RT @A_Ra_Berlin: Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как т…
RT @A_Ra_Berlin: Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как т…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @A_Ra_Berlin: Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как т…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
Имеют ли жирные кислоты Омега-3 долгосрочное превентивное влияние на депрессивные эпизоды среди старшего населения? Как то не очень. В принципе результат в сравнении с плацебо даже минимально наоборот. https://t.co/0xxIaTML5B https://t.co/k92ehGGnBB
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent depression https://t.co/NZdW8aHis5
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent depression https://t.co/uyRpsDT7zP https://t.co/LaWC3HfpkG
RT @JAMA_current: Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent…
Findings of a new randomized clinical trial do not support the use of omega-3 fatty acid supplements in adults to prevent depression https://t.co/dR5cm5C9dT https://t.co/Ybrazlmfca