Most discussions emphasize the significance of Omicron's less efficient replication and entry mechanisms, citing specific studies and molecular pathways such as endocytosis versus TMPRSS2 reliance. The tone varies from scientific analysis to skepticism about treatment claims like hydroxychloroquine, illustrating both curiosity and debate about the research's implications and real-world effects.
AgreementModerate agreement
Most discussions align with the article's findings, acknowledging Omicron's reduced replication and fusion activity compared to Delta.
InterestHigh interest
Posts show high curiosity and focus on the implications of the research, with many referencing specific molecular mechanisms and potential clinical effects.
EngagementHigh engagement
Several discussions involve detailed analysis, references to multiple studies, and debates over the virus’s behavior and treatment strategies, indicating deep engagement.
ImpactModerate impact
The conversations reflect significant interest in the potential impact on disease severity and treatment efficacy, though some skepticism remains about real-world applicability.
Abstract in brief
The Omicron variant of SARS-CoV-2 shows less efficient replication and cell fusion activity compared to the Delta variant, especially in cells expressing TMPRSS2, an enzyme involved in viral entry.
Omicron primarily uses the endocytic pathway to infect cells, which is different from Delta that relies more on TMPRSS2, and this can influence how the virus behaves and potentially affects disease severity.
These differences in how the two variants enter cells and replicate could impact their transmissibility, immune escape, and clinical outcomes.]
Jan 5, 2022 · 69 likes · 29 shares · 13,557 followersView post →
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Alexandre Aguiar
@alexaguiarpoa · X
Jair Bolsonaro disse nesta noite em sua live que a cloroquina pode funcionar contra a Ômicron. De onde ele tirou isso? Durante toda a semana circulou em grupos governistas um trabalho de pesquisadores de Hong Kong que foi para a rede antes do Natal. https://t.co/OM6jMKBBCy
Dec 30, 2021 · 37 likes · 3 shares · 45,435 followersView post →
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Dr Siddharth Sridhar
@sid8998 · X
Great work at speed from @Kelvinkwto lab of @hkumed on #Omicron's replication kinetics, now published in @tandfonline's Emerging Microbes and Infections.
https://t.co/ffcl49dbp1
Dec 25, 2021 · 27 likes · 8 shares · 5,484 followersView post →
Hace aproximadamente un año se publicó un estudio en el que se mostraba que la variante ómicron presentaba menos capacidad infectiva en células que expresaban TMPRSS2, una proteasa de membrana presente en células de pulmón.
https://t.co/ORaE10464W
Dec 17, 2022 · 14 likes · 3 shares · 1,522 followersView post →
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FJ
@pistoto2017 · X
https://t.co/EUbhDAbI16 Youtuber Chino que no se olvida del Aplidin (desde el minuto 7:30). + de 348000 suscriptores, lleva + de 40000 visualizaciones. @BolsaCosas @Kostarof @CostaTejedor @VpTraderLife @FjOliver2 @PropiaBolsa @toniscuo @richard69967440 @jjboix @NoeliaG99962397
The Omicron variant of SARS-CoV-2 exhibits less efficient replication and cell fusion activity compared to the Delta variant, particularly in TMPRSS2-expressing cells. It primarily uses the endocytic pathway for…
The Omicron variant shows less efficient replication and fusion activity compared to Delta. It primarily uses endocytic entry rather than TMPRSS2, affecting transmissibility, immune escape, and disease severity.
@PinsolleT @CaudeHenrion @SabinehazanMD @WakingUp2020 @P_J_Buckhaults Clairement... d'autant plus que je doute de son efficacité réelle sur les variants Omicron.
https://t.co/mmugATkHtg
https://t.co/3WymEdsMoB
https://t.co/VJWbpLHJvg
Les études semblent contradictoires, ce qui demande de plus amples investigations concernant le rôle de TMPRSS2
Mar 18, 2024 · 4 likes · 30,499 followersView post →
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janey
@janey15408827 · X
@janiesaysyay @SitSilver @fivehundredpou1 TMPRSS2 upper respiratory and endothelial
https://t.co/Kc4G5EkyZo
@kalevleetaru ( the prion region fell off )
And The Frankinstein parts said ..." I cant spread like this ...I'm killing everyone ..."
But, they still putting franky in them jabs?
https://t.co/1hF6N3cSq5
@theyareus2 For anti-covid mRNA injections, yes !!! For the virus?
https://t.co/BOmdkPQnUt
https://t.co/5k2wP5XgQs
Omicron has acquired an inoperative furin site (S1-S2). Without this cleavage, no exposure of CendR ("RRAR" sequence). Does it mean that Omicron is less dangerous ?
RT @glopllu69: Hace aproximadamente un año se publicó un estudio en el que se mostraba que la variante ómicron presentaba menos capacidad i…
Dec 18, 2022 · 3 shares · 15,439 followersView post →
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Guillermo Lopez Lluch
@glopllu69 · X
Hace aproximadamente un año se publicó un estudio en el que se mostraba que la variante ómicron presentaba menos capacidad infectiva en células que expresaban TMPRSS2, una proteasa de membrana presente en células de pulmón.
https://t.co/ORaE10464W
Dec 17, 2022 · 14 likes · 3 shares · 1,522 followersView post →
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_chAyA_
@_chAyA_ · X
RT @neorevolt: @laurieallee 3) IMHO, the reason for low fatality & symptomatic cases is the fact that the original strains entered through…
RT @ivermectin_team: SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TM…
Nov 10, 2022 · 1 share · 1,927 followersView post →
チイ
チーム イベルメクチン
@ivermectin_team · X
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells
Accepted 22 December 2021
https://t.co/5uJherFtfT
@DrRSheth11 @DeeEternalOpt Omicron was mild even for the unwxxed. It's not the wxx which alone made it mild.
Original variants entered through TMPRSS2, ACE2 & Endosomal. Omicron prefers Endosomal entry which leads to less lung involvement & less Oxygen saturation issues.
https://t.co/XjKhOCV0OC
Oct 15, 2022 · 1 share · 2,302 followersView post →
https://t.co/EUbhDAbI16 Youtuber Chino que no se olvida del Aplidin (desde el minuto 7:30). + de 348000 suscriptores, lleva + de 40000 visualizaciones. @BolsaCosas @Kostarof @CostaTejedor @VpTraderLife @FjOliver2 @PropiaBolsa @toniscuo @richard69967440 @jjboix @NoeliaG99962397
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells https://t.co/Z9I6IsVbTU
@laurieallee 3) IMHO, the reason for low fatality & symptomatic cases is the fact that the original strains entered through TMPRSS2, ACE2 & Endosomal. Whereas Omicron seems to prefer Endosomal which leads to less lung involvement & less Oxygen saturation issues.
https://t.co/XjKhOCV0OC
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells https://t.co/qhfCdnNUmK
@EmilevanKrieken I think this is it... my tabs are a bit of a mess atm and I know its somewhere in the pile... but im pretty sure this is it
https://t.co/5rH5PCw3uf
@seanonolennon HCQ seems to be more effective because it inhibits the endocytic pathway thus the reducing the replication of the virus for both Delta and Omicron in the early stages of the infection. We need medicines for the early stages, not only vaccines. https://t.co/1I4VXIsXp4
RT @PatrickSSte: 1/ Omicron seems to be a strain that specializes in gaining entry to human cells by endocytosis (ie being engulfed by the…
Jan 18, 2022 · 4 shares · 344 followersView post →
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AnKo
@anko_979 · X
@kargioge Και απ' αυτά που παρέθεσες προκύπτει ότι δεν έχει βρεθεί άλλος παρόμοιος υποδοχέας. Καταλαβαίνω ότι δεν αναφέρεσαι σε δυνατότητες τύπου endocytic entry που βλέπουμε παραπάνω με το Omicron https://t.co/Yye8jjI8am.
RT @PatrickSSte: 1/ Omicron seems to be a strain that specializes in gaining entry to human cells by endocytosis (ie being engulfed by the…
Jan 15, 2022 · 4 shares · 3,665 followersView post →
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Ananda
@Ananda10149510 · X
RT @PatrickSSte: 1/ Omicron seems to be a strain that specializes in gaining entry to human cells by endocytosis (ie being engulfed by the…
Jan 15, 2022 · 4 shares · 474 followersView post →
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Patrick Shaw Stewart
@PatrickSSte · X
1/ Omicron seems to be a strain that specializes in gaining entry to human cells by endocytosis (ie being engulfed by the cell rather like an amoeba engulfing its prey)
https://t.co/FFXHlTbWMc
Jan 15, 2022 · 10 likes · 4 shares · 2,126 followersView post →
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Théorie Du Pangolin
@du_pangolin · X
RT @tony_vandongen: @PatrickSSte @K_G_Andersen @macroliter @stuartjdneil The severely reduced ability to cause cell-cell fusion, which has…
@PatrickSSte @K_G_Andersen @macroliter @stuartjdneil The severely reduced ability to cause cell-cell fusion, which has been demonstrated in several in vitro studies, could be part of the reason it is less pathogenic. This is possibly related to Omicron favoring an endosome-based entry pathway:
https://t.co/leh8ehYrID
Jan 11, 2022 · 5 likes · 1 share · 7,393 followersView post →
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Dick Janssen
@DickJanssen7 · X
Omicron is ook minder virulent doordat 2) het zich vooral in bronchiën vermeerdert en minder diep in longen. In de longen gebruikt het Spike eiwit van Delta het TMPRSS2 eiwit van longcellen om die cellen binnen te dringen. 13/n
https://t.co/Ne1rIC7pNV
"A novel SARS-CoV-2 lineage B.1.1.529, first reported by South Africa and Bostwana, has been classified by the World Health Organization as a VOC on 26th November 2021 [14]. This novel variant, now known as the Omicron variant, is…https://t.co/4BevMarxNX https://t.co/aVAyesrgAp
RT @EladSharonMD: @happyhexer @nytimes @V2019N It’s interesting to read this now, but as far as I know, omicron is less efficient at using…
Jan 7, 2022 · 1 share · 1,204 followersView post →
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Elad Sharon
@EladSharonMD · X
@happyhexer @nytimes @V2019N It’s interesting to read this now, but as far as I know, omicron is less efficient at using tmprss2: https://t.co/FoEqnoK7xk
Jan 7, 2022 · 11 likes · 1 share · 3,967 followersView post →
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The GUT CLUB
@club_gut · X
Endocytic pathway:
https://t.co/74w1FUJ37R
Note: might this infer increased infectivity by Omicron in the gut?
@bicidiario https://t.co/mNSgOS0GRm
https://t.co/7c12PRFimE
https://t.co/PM5J8kUnMM (riassunto di vari studi)
Jan 2, 2022 · 9 likes · 1 share · 8,124 followersView post →
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Ecnarf Eviv Bulgroz
@evivyop · X
Ok in vitro et preprint, mais ça semble deja répété par d'autres labos https://t.co/JE83buD2fg
https://t.co/WskKOHwQal
Jan 2, 2022 · 5 likes · 1,435 followersView post →
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Ecnarf Eviv Bulgroz
@evivyop · X
- la mortalité peine à décoller en AdS
https://t.co/WskKOHwQal https://t.co/vp5IGaaUzL
Jan 2, 2022 · 11 likes · 1,435 followersView post →
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SALMO RASKIN
@RaskinSalmo · X
https://t.co/lfzWe5j1VT
Jan 2, 2022 · 8 likes · 4,504 followersView post →
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siddharthgpf
@siddharthgpf · X
RT @RajeevJayadevan: Omicron shows less efficient replication and fusion activity than delta in TMPRSS2-expressed lab cells.
“Omicron infe…
Jan 1, 2022 · 3 shares · 2,456 followersView post →
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Dr. Shashank Joshi
@AskDrShashank · X
RT @RajeevJayadevan: Omicron shows less efficient replication and fusion activity than delta in TMPRSS2-expressed lab cells.
“Omicron infe…
Jan 1, 2022 · 3 shares · 32,625 followersView post →
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VARUN DAS
@das_varun99 · X
RT @RajeevJayadevan: Omicron shows less efficient replication and fusion activity than delta in TMPRSS2-expressed lab cells.
“Omicron infe…
Jan 1, 2022 · 3 shares · 1,458 followersView post →
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Rajeev Jayadevan
@RajeevJayadevan · X
Omicron shows less efficient replication and fusion activity than delta in TMPRSS2-expressed lab cells.
“Omicron infection is not enhanced by TMPRSS2 but is largely mediated by endocytic pathway”
Note viruses use multiple mechanisms to enter cells.
1/2
https://t.co/da9MEazLUj
Jan 1, 2022 · 11 likes · 3 shares · 11,438 followersView post →
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Shabazz
@theblackestlist · X
@physicsheretic @charliekirk11 ...happens later on in infection. So this explains what you were talking about, which btw I didn't disagree with that part because it was new info to me. The only thing I was disagreeing with was your explanation of the spike protein.
https://t.co/C653vVKGyU
@EricTopol THIS ONE BELOW IS AN IN VITRO STUDYING DISCUSSING REPURPOSING OF HCQ, AS OMICRON ENTERS VIA ENDOSSOMAL PATHWAY. https://t.co/lfzWe5j1VT
Dec 31, 2021 · 1 like · 1 share · 4,504 followersView post →
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Carlos Zeferino
@CarlosJZeferino · X
RT @alexaguiarpoa: Jair Bolsonaro disse nesta noite em sua live que a cloroquina pode funcionar contra a Ômicron. De onde ele tirou isso? D…
Dec 30, 2021 · 3 shares · 389 followersView post →
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lenhagui
@lenhagui · X
RT @alexaguiarpoa: Jair Bolsonaro disse nesta noite em sua live que a cloroquina pode funcionar contra a Ômicron. De onde ele tirou isso? D…
Dec 30, 2021 · 3 shares · 3,390 followersView post →
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Alexandre Aguiar
@alexaguiarpoa · X
Jair Bolsonaro disse nesta noite em sua live que a cloroquina pode funcionar contra a Ômicron. De onde ele tirou isso? Durante toda a semana circulou em grupos governistas um trabalho de pesquisadores de Hong Kong que foi para a rede antes do Natal. https://t.co/OM6jMKBBCy
Dec 30, 2021 · 37 likes · 3 shares · 45,435 followersView post →
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Dror
@drorsos · X
@Meir_Rubin מעניין.
המחקר המצ"ב טוען שהאומי לא יודע לנצל את נתיב TMPRSS2 ולכל מדביק פחות תאי ריאה
https://t.co/mcHpoWKmyz
Dec 30, 2021 · 3 likes · 2,260 followersView post →
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Dror
@drorsos · X
@erlichya Is less efficiency in replication in TMPRSS2 expressed cells is the reason of it being 'milder'?
If so, could it revert this loss of ability?
https://t.co/mcHpoWKmyz
We believe that 2022 will be a year of normalcy. Preliminary medical research has proven that the Omicron variant may have poorer replication in the lungs when compared with the Delta variant. --> leading to milder, less severe disease
https://t.co/Sg9zIIuw7u
But I haven't seen any clinical data on COVID(omicron) related pneumonia, so I don't know how applicable to real world clinical settings this result should be.
https://t.co/9sBYGnuQcy
Deixem só o @jairbolsonaro saber disso. https://t.co/ukCrAhTbNv https://t.co/MRnJHuJT14
Dec 27, 2021 · 1 like · 1 share · 1,123 followersView post →
TL
the paper link
@the_paper_link · X
Trend new: Zhao H, ..., To KK (Emerg Microbes Infect) __SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells__
https://t.co/uGvjP19Ssq
La nueva variante Omicrón del SARS-CoV-2 (B.1.1.529) se replicó más lentamente que la variante Delta en las células que sobre expresan TMPRSS2. Esto pudiera tener implicaciones en las manifestaciones clínicas o la gravedad de la enfermedad.
https://t.co/HxZapV7z7X
@paulopola @Dr_Francisco_ Posso estar enganado, mas creio que ele esteja se referindo a este estudo que cita que a hcq pode reduzir a replicação viral da ômicron e delta.
https://t.co/d8lr7qWjfq
Dec 27, 2021 · 3 likes · 1 share · 150 followersView post →
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Rodrigo
@CharlieStvi · X
RT @Ramon4lan: Leiam o artigo: https://t.co/CaEGlNBJl0
Traduzam e verao do porque cloroquina foi massacrada pela midia e afins.
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells: https://t.co/DXdrsQVEWj
RT @sid8998: Great work at speed from @Kelvinkwto lab of @hkumed on #Omicron's replication kinetics, now published in @tandfonline's Emergi…
Dec 25, 2021 · 8 shares · 741 followersView post →
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Tony Wayland
@Fullyfallible · X
RT @sid8998: Great work at speed from @Kelvinkwto lab of @hkumed on #Omicron's replication kinetics, now published in @tandfonline's Emergi…
Dec 25, 2021 · 8 shares · 249 followersView post →
FN
Flávio Nunes
@flavionunesxo · X
O B tem razão!
SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in… https://t.co/kv3cUjfEnb
Great work at speed from @Kelvinkwto lab of @hkumed on #Omicron's replication kinetics, now published in @tandfonline's Emerging Microbes and Infections.
https://t.co/ffcl49dbp1
Dec 25, 2021 · 27 likes · 8 shares · 5,484 followersView post →
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Ricardo Machado, BES, DVM
@Fangorn17 · X
@ZimermanRicardo Vc acha que a eficácia da proxalutamida vai ser menor contra omicron?
https://t.co/DPJeOAuNrD
Dec 25, 2021 · 7 likes · 1 share · 204 followersView post →
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Jussi Tuusa
@jttuusa · X
Another paper that promotes enjoying salty licorice (salmiakki or NH4Cl).
https://t.co/TpSUgTRIIX