Real-time X-ray imaging of mouse cerebral microvessels in vivo using a pixel temporal averaging method.

Abstract in brief

• The paper introduces a pixel temporal averaging (PTA) method that allows for real-time X-ray imaging of mouse brain microvessels in vivo, effectively reducing motion artifacts and noise to improve image quality.
• Experiments demonstrated that PTA significantly enhances contrast-to-noise ratio, enables microvessel detection with less photon flux, and can produce images in about 250 milliseconds using standard computers, making real-time imaging feasible.
• The PTA technique was successfully tested with both conventional X-ray tubes and laboratory X-ray sources, suggesting it can be a valuable tool for studying cerebral microvascular diseases in small animal models.]