January 2022 PMID 35015522

Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase.

Sevan Habeshian, Ganesh A Sable, Mischa Schüttel, Manuel L Merz, Christian Heinis

Mentions

18
Peak: 14 in Jan 2022
across 3 sources since Jan 2022

Extended reach

24,519
potential audience

Total likes

76

Video views

1,425

Mentions per month

Jan 2022 – Feb 2023

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The overall comments eagerly praise the innovation, such as references to the method enabling rapid macrocyclic drug discovery and phrases like 'powerful' and 'congrats,' which reflect excitement and recognition of its significance. The tone is highly positive and uses words that convey both admiration and anticipation for broad impact in the field.

AgreementStrong agreement

All discussions express strong support and enthusiasm for the new method, highlighting its innovation and potential applications.

InterestHigh interest

The discussions reflect high interest, with mentions of high-throughput synthesis, drug discovery, and specific praise for the researchers involved.

EngagementHigh engagement

Participants actively engage by praising the method, naming key contributors, and emphasizing the significance of the approach's efficiency and novelty.

ImpactHigh impact

The discussions underscore the substantial potential impact on drug development, synthesis efficiency, and scientific advancement, describing the approach as a 'game changer' or 'powerful' new technique.

Abstract in brief

  • The study introduces a new Cyclative Release Strategy that allows the direct production of pure cyclic peptides from solid-phase synthesis, eliminating the need for chromatographic purification.
  • Peptides are synthesized with an N-terminal thiol and a C-terminal disulfide linker, with sidechain protecting groups removed while still on the solid phase, then released through an intramolecular disulfide exchange triggered by a base.
  • This method is efficient for high-throughput production, enabling fast synthesis and screening of hundreds of cyclic peptides, which are important for drug development, including drugs like oxytocin and vasopressin.

Top posts

Most liked on X and Bluesky
ProPepChem
@ProPepChem · X

Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublications https://t.co/1bfV5k6BIu

Jan 16, 2022 · 41 likes · 6 shares · 975 followers View post →
Alexander L. Nielsen
@alexanderln91 · X

New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPFL_CHEM_Tweet https://t.co/zhYZE8FeIO

Jan 13, 2022 · 32 likes · 6 shares · 587 followers View post →
Ganesh Sable
@sganesh105 · X

A powerful way to make 100s of PURE peptide/peptoid macrocycles directly from the resin. Rapid way in macrocyclic drug discovery. Congrats Sevan, co-authors and Christian Heinis. @EPFL, #macrocycles, #peptides, #Peptoids https://t.co/ZEoxKPFOK7

Jan 25, 2022 · 3 likes · 87 followers View post →
Waser Group
@LcsoLab · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 20, 2022 · 6 shares · 14,062 followers View post →
Goss Group
@GossGroup · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 1,709 followers View post →
DYNAFLUORS
@dynafluors · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 1,405 followers View post →

All mentions

Ganesh Sable
@sganesh105 · X

A powerful way to make 100s of PURE peptide/peptoid macrocycles directly from the resin. Rapid way in macrocyclic drug discovery. Congrats Sevan, co-authors and Christian Heinis. @EPFL, #macrocycles, #peptides, #Peptoids https://t.co/ZEoxKPFOK7

Jan 25, 2022 · 3 likes · 87 followers View post →
Waser Group
@LcsoLab · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 20, 2022 · 6 shares · 14,062 followers View post →
Van-Thang Nguyen
@Eyeshield_VN_21 · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 349 followers View post →
Goss Group
@GossGroup · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 1,709 followers View post →
DYNAFLUORS
@dynafluors · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 1,405 followers View post →
Valérie ROLLAND
@Valrie34ROLLAND · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 491 followers View post →
Sebastian Pomplun
@PomplunSeb · X

RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…

Jan 16, 2022 · 6 shares · 1,389 followers View post →
ProPepChem
@ProPepChem · X

Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublications https://t.co/1bfV5k6BIu

Jan 16, 2022 · 41 likes · 6 shares · 975 followers View post →
Dongchen Du
@DongchenD · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 14, 2022 · 6 shares · 268 followers View post →
Bo Li
@BoLi_Pep · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 14, 2022 · 6 shares · 77 followers View post →
Xinjian-ch
@ChXinjian · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 14, 2022 · 6 shares · 40 followers View post →
A. G. Roberts chemistry
@agr_chemistry · X

RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…

Jan 14, 2022 · 6 shares · 955 followers View post →
Alexander L. Nielsen
@alexanderln91 · X

New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPFL_CHEM_Tweet https://t.co/zhYZE8FeIO

Jan 13, 2022 · 32 likes · 6 shares · 587 followers View post →
MyJournals
@myjournals · X

[ASAP] Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase https://t.co/kH7QzWs4WU

Jan 11, 2022 · 557 followers View post →