Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublications https://t.co/1bfV5k6BIu
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase.
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Jan 2022 – Feb 2023Where it's discussed
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X / Twitter14 posts
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YouTube2 videos
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News2 articles
AI synopsis
What people are saying
The overall comments eagerly praise the innovation, such as references to the method enabling rapid macrocyclic drug discovery and phrases like 'powerful' and 'congrats,' which reflect excitement and recognition of its significance. The tone is highly positive and uses words that convey both admiration and anticipation for broad impact in the field.
All discussions express strong support and enthusiasm for the new method, highlighting its innovation and potential applications.
The discussions reflect high interest, with mentions of high-throughput synthesis, drug discovery, and specific praise for the researchers involved.
Participants actively engage by praising the method, naming key contributors, and emphasizing the significance of the approach's efficiency and novelty.
The discussions underscore the substantial potential impact on drug development, synthesis efficiency, and scientific advancement, describing the approach as a 'game changer' or 'powerful' new technique.
Abstract in brief
- The study introduces a new Cyclative Release Strategy that allows the direct production of pure cyclic peptides from solid-phase synthesis, eliminating the need for chromatographic purification.
- Peptides are synthesized with an N-terminal thiol and a C-terminal disulfide linker, with sidechain protecting groups removed while still on the solid phase, then released through an intramolecular disulfide exchange triggered by a base.
- This method is efficient for high-throughput production, enabling fast synthesis and screening of hundreds of cyclic peptides, which are important for drug development, including drugs like oxytocin and vasopressin.
Top posts
Most liked on X and BlueskyNew approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPFL_CHEM_Tweet https://t.co/zhYZE8FeIO
A powerful way to make 100s of PURE peptide/peptoid macrocycles directly from the resin. Rapid way in macrocyclic drug discovery. Congrats Sevan, co-authors and Christian Heinis. @EPFL, #macrocycles, #peptides, #Peptoids https://t.co/ZEoxKPFOK7
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
All mentions
High-Throughput Synthesis and Screening of Macrocyclic Peptide Libraries
Learn about CEM's peptide synthesis solutions and high-throughput methods for creating and screening macrocyclic peptide libraries using robotic automation and acoustic dispensing.
High-Throughput Synthesis of Macrocyclic Peptide Libraries using Acoustic Liquid Transfer
Learn about CEMs peptide synthesis solutions including robotic automation and acoustic dispensing for high-throughput screening of macrocyclic peptides.
A powerful way to make 100s of PURE peptide/peptoid macrocycles directly from the resin. Rapid way in macrocyclic drug discovery. Congrats Sevan, co-authors and Christian Heinis. @EPFL, #macrocycles, #peptides, #Peptoids https://t.co/ZEoxKPFOK7
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
RT @ProPepChem: Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublic…
Christian Heinis and colleagues from @EPFL_CHEM_Tweet utilise thiol groups for catch and release via cyclisation @ACSPublications https://t.co/1bfV5k6BIu
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
RT @alexanderln91: New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPF…
New approach for cyclative release of dithiol peptides on resin from the Heinis lab. Congrats Sevan and co-workers! @EPFL_CHEM_Tweet https://t.co/zhYZE8FeIO
[ASAP] Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase https://t.co/kH7QzWs4WU