J Immunother Cancer January 2022 PMID 35017149

CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.

Mathieu Seyfrid, William Thomas Maich, Vaseem Muhammad Shaikh, Nazanin Tatari, Deepak Upreti, Deween Piyasena, Minomi Subapanditha, Neil Savage, Dillon McKenna, Nicholas Mikolajewicz, Hong Han, Chirayu Chokshi, Laura Kuhlmann, Amanda Khoo, Sabra Khalid Salim

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Mentions

8
Peak: 5 in Jan 2022
across 3 sources since Jan 2022

Extended reach

14,197
potential audience

Total likes

15

Video views

273

Mentions per month

Jan 2022 – Mar 2022

Where it's discussed

  • X / Twitter5 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect excitement about targeting CD70 in glioblastoma, with words like 'promising' and 'important' highlighting perceived significance. Posts referencing the development of CAR T-cell therapy suggest deep engagement with the therapeutic potential, while mentions of 'microenvironment' and 'immune modulation' reveal interest in mechanistic insights, contributing to overall positive perception and recognition of the research's impact.

AgreementModerate agreement

The posts generally express positive reactions and acknowledgment of the research's potential.

InterestHigh interest

There is high enthusiasm and curiosity about the therapeutic implications and the new target identified in the study.

EngagementModerate engagement

Discussions include mentions of the methodology and potential for clinical translation, indicating moderate depth of engagement.

ImpactModerate impact

Participants recognize the significance of the findings, but discussions are still emerging, suggesting moderate perceived impact.

Abstract in brief

  • The study identifies CD70 as a promising immunotherapeutic target in recurrent glioblastoma (GBM), showing that reducing CD70 expression decreases tumor growth and progression.
  • Researchers developed anti-CD70 CAR T-cell therapy, which significantly improved survival in preclinical GBM models, and also explored the presence of CD27 on immune cells within the tumor environment.
  • The findings suggest that targeting the CD70/CD27 axis could be an effective multi-faceted approach to treating recurrent GBM by attacking tumor cells and modulating the immune microenvironment.

Top posts

Most liked on X and Bluesky
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https://t.co/e7Ofg3IDhW @sheilasinghlab https://t.co/rEjpPHd2MP

Jan 12, 2022 · 14 likes · 4 shares · 9,312 followers View post →
Alliance for Cancer Gene Therapy
@ACGTFoundation · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Mar 7, 2022 · 4 shares · 2,149 followers View post →
Sheila Singh Brain Tumour Lab
@sheilasinghlab · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Jan 19, 2022 · 4 shares · 1,351 followers View post →
Anthony Rullo: chemically modulating proximity
@LabRullo · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Jan 19, 2022 · 4 shares · 933 followers View post →

All mentions

Alliance for Cancer Gene Therapy
@ACGTFoundation · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Mar 7, 2022 · 4 shares · 2,149 followers View post →
Anthony Rullo: chemically modulating proximity
@LabRullo · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Jan 19, 2022 · 4 shares · 933 followers View post →
Sheila Singh Brain Tumour Lab
@sheilasinghlab · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Jan 19, 2022 · 4 shares · 1,351 followers View post →
Lisksama
@Lisksama1 · X

RT @jitcancer: New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https:/…

Jan 13, 2022 · 4 shares · 139 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment https://t.co/e7Ofg3IDhW @sheilasinghlab https://t.co/rEjpPHd2MP

Jan 12, 2022 · 14 likes · 4 shares · 9,312 followers View post →