J Affect Disord March 2022 PMID 35027209

A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings.

L Alison McInnes, Jimmy J Qian, Rishab S Gargeya, Charles DeBattista, Boris D Heifets

Mentions

32
Peak: 2 in Aug 2024
across 5 sources since Jan 2022

Extended reach

7,024
potential audience

Total likes

7

Video views

194

Mentions per month

Jan 2022 – Jan 2025

Where it's discussed

  • News22 articles
  • Blogs4 articles
  • X / Twitter2 posts
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions show a cautious optimism, with remarks like 'some response is promising' and questions about the variability in scores, reflecting engagement with both the data and its implications. The tone balances interest with critical consideration of the findings' real-world relevance.

AgreementModerate agreement

Most users seem to agree that the research shows promising results, with some noting similar findings from their own studies.

InterestModerate interest

Discussions demonstrate moderate curiosity, particularly about how results translate to real-world settings and the variations in patient responses.

EngagementModerate engagement

Participants reference specific data points, such as the 54% response rate and 29% remission, indicating a moderate level of engagement with the content.

ImpactModerate impact

The discussions highlight potential impacts on clinical practices and the importance of understanding patient variability, suggesting a meaningful, though not transformative, influence.

Abstract in brief

  • A large retrospective study of 9,016 depression patients across 178 U.S. clinics found that ketamine intravenous therapy (KIT) significantly reduced depression symptoms, with about 99.8% of patients responding positively after induction treatment.
  • Most patients maintained their antidepressant response for several weeks, with an 80% chance of sustained response at 4 weeks and 60% at 8 weeks, even without ongoing infusions.
  • While KIT was generally effective, a small percentage of patients experienced worsening symptoms, and effects were slightly stronger in more severely depressed individuals, but overall response rates were consistent regardless of initial depression severity.]

Top posts

Most liked on X and Bluesky
Boris D Heifets
@TheBorisLab · X

@ferenstein We saw something similar in a study we did https://t.co/XFFoK5KYLB One thing I wondered - given that PHQ scores will vary from day to day, how do you interpret a worse score on a retest? Some proportion will score worse with the same symptoms.

Aug 22, 2024 · 2 likes · 3,472 followers View post →
Blossom
@blossomact · X

Of the patients, 54% showed a response (<50% on PHQ-9), 29% met the more stringent criteria of remission (<5 PHQ-9 score) Though for about 9% there was an increase in depressive symptoms https://t.co/ECrKWwJ5n4 3/9

Jan 25, 2022 · 3,355 followers View post →
Osmind
@osmind.bsky.social · Bluesky

1) Poster Presentation: Title: A Retrospective Analysis of Ketamine Intravenous Therapy for PTSD in Real-World Care Settings Date & Time: Thursday, 1/23, 6:00 PM – 7:30 PM Location: Moontower Hall Speaker: Dr. L. Alison McInnes MD, MS, Osmind’s VP of Scientific Affairs

Jan 15, 2025 · 1 share View post →
Osmind
@osmind.bsky.social · Bluesky

1) A Retrospective Analysis of Ketamine Intravenous Therapy for PTSD in Real-World Care SettingsLed by Rob Berman, M.D. (Yale University, Osmind Strategic Advisor) & L. Alison McInnes MD, MS McInnes, M.D., MS (VP of Scientific Affairs, Osmind)

Dec 13, 2024 · 1 share View post →

All mentions

Osmind
@osmind.bsky.social · Bluesky

1) Poster Presentation: Title: A Retrospective Analysis of Ketamine Intravenous Therapy for PTSD in Real-World Care Settings Date & Time: Thursday, 1/23, 6:00 PM – 7:30 PM Location: Moontower Hall Speaker: Dr. L. Alison McInnes MD, MS, Osmind’s VP of Scientific Affairs

Jan 15, 2025 · 1 share View post →
Osmind
@osmind.bsky.social · Bluesky

1) A Retrospective Analysis of Ketamine Intravenous Therapy for PTSD in Real-World Care SettingsLed by Rob Berman, M.D. (Yale University, Osmind Strategic Advisor) & L. Alison McInnes MD, MS McInnes, M.D., MS (VP of Scientific Affairs, Osmind)

Dec 13, 2024 · 1 share View post →
Boris D Heifets
@TheBorisLab · X

@ferenstein We saw something similar in a study we did https://t.co/XFFoK5KYLB One thing I wondered - given that PHQ scores will vary from day to day, how do you interpret a worse score on a retest? Some proportion will score worse with the same symptoms.

Aug 22, 2024 · 2 likes · 3,472 followers View post →
Blossom
@blossomact · X

Of the patients, 54% showed a response (<50% on PHQ-9), 29% met the more stringent criteria of remission (<5 PHQ-9 score) Though for about 9% there was an increase in depressive symptoms https://t.co/ECrKWwJ5n4 3/9

Jan 25, 2022 · 3,355 followers View post →