Mol Psychiatry March 2022 PMID 35027679

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis.

Luis C Farhat, José M Flores, Emily Behling, Victor J Avila-Quintero, Adam Lombroso, Samuele Cortese, Guilherme V Polanczyk, Michael H Bloch

Mentions

13
Peak: 8 in Jan 2022
across 2 sources since Oct 2011

Extended reach

107,859
potential audience

Total likes

593

Video views

80,003

Mentions per month

Oct 2011 – May 2024

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group demonstrates strong support for the study’s conclusion that flexible dosing improves treatment outcomes, using words like 'supports', 'promoting better personalization', and 'improved efficacy'. The tone is positive and emphasizes clinical and practical implications, indicating a high-impact conversation about advancing ADHD treatment strategies.

AgreementStrong agreement

Most discussions praise the study for confirming the benefits of flexible dosing strategies, indicating strong support.

InterestHigh interest

The posts show high engagement with the topic, emphasizing its relevance for ADHD treatment approaches.

EngagementHigh engagement

Posts reference specific concepts like 'personalization', 'efficacy', and 'informed dosage strategies', showing deep involvement.

ImpactHigh impact

The discussions highlight the potential for these findings to influence clinical practice and patient outcomes, suggesting high significance.

Abstract in brief

  • This meta-analysis examined how different doses and strategies of stimulant medications like methylphenidate (MPH) and amphetamines (AMP) affect treatment success, side effects, and discontinuation rates in children and adolescents with ADHD.
  • It found that higher fixed doses of stimulants improve symptom control but also increase side effects and discontinuations, with the most benefit seen up to around 30mg for MPH and 20mg for AMP, beyond which additional gains are minimal.
  • Flexible dosing strategies tend to balance efficacy and tolerability better, suggesting that individualized dosing may optimize treatment outcomes in ADHD by adjusting doses to the patient's response while minimizing adverse effects.]

Top posts

Most liked on X and Bluesky
Psiquiatria Infantil
@PsiqInfantil · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis | Molecular Psychiatry https://t.co/gszIE0Mx3g

Jan 15, 2022 · 3 likes · 4,103 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis https://t.co/t4zMA32hsY

Jan 17, 2022 · 1 like · 1,014 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @ihyperu: The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in childre…

Jan 13, 2022 · 1 share · 6,711 followers View post →
Dr. Charles Parker
@drcharlesparker · X

@StephenFaraone Thanks, Steve, completely agree, - well said. I have a vid playlist on this topic for everyone I see on stim meds: https://t.co/MGQAjt9hUc

Mar 30, 2022 · 5,116 followers View post →
Dr. Charles Parker
@drcharlesparker · X

This article supports informed dosage strategies: https://t.co/MGQAjt9hUc https://t.co/k80TPoBB5P

Jan 21, 2022 · 5,116 followers View post →
Samuele Cortese
@CorteseSamuele · X

See also: https://t.co/3CWBZDgV8N https://t.co/VfeoA0RBfx

Jan 19, 2022 · 3,954 followers View post →

All mentions

Child Development Matters
@ChildDMatters · X

A new study supports flexible dosing strategies over fixed doses for ADHD treatments, promoting better personalization and effectiveness. Details: https://t.co/FTN4ZREpig #LatestResearch #ADHDCare #ChildDMatters 4/5 https://t.co/mfw2skNbhb

May 18, 2024 · 59 followers View post →
Adult ADHD India
@adultADHDindia · X

2. Meta-analysis finds flexible stimulant titration - as needed (considering the presence of ADHD symptoms), - as tolerated (considering the presence of dose-limiting AEs), - to higher doses, is associated with improved efficacy and acceptability https://t.co/qrAGitOZoS

Mar 25, 2024 · 535 followers View post →
Dr. Charles Parker
@drcharlesparker · X

@StephenFaraone Thanks, Steve, completely agree, - well said. I have a vid playlist on this topic for everyone I see on stim meds: https://t.co/MGQAjt9hUc

Mar 30, 2022 · 5,116 followers View post →
Dr. Charles Parker
@drcharlesparker · X

This article supports informed dosage strategies: https://t.co/MGQAjt9hUc https://t.co/k80TPoBB5P

Jan 21, 2022 · 5,116 followers View post →
Samuele Cortese
@CorteseSamuele · X

See also: https://t.co/3CWBZDgV8N https://t.co/VfeoA0RBfx

Jan 19, 2022 · 3,954 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis https://t.co/t4zMA32hsY

Jan 17, 2022 · 1 like · 1,014 followers View post →
Psiquiatria Infantil
@PsiqInfantil · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis | Molecular Psychiatry https://t.co/gszIE0Mx3g

Jan 15, 2022 · 3 likes · 4,103 followers View post →
MasMaz
@MasMazCom · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis - https://t.co/51GwPgReWT

Jan 14, 2022 · 169 followers View post →
Dataemia
@Dataemia · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis - https://t.co/LU0GUQx7JH

Jan 14, 2022 · 966 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @ihyperu: The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in childre…

Jan 13, 2022 · 1 share · 6,711 followers View post →
ihyperu
@ihyperu · X

The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis https://t.co/arJqedJ4Y6

Jan 13, 2022 · 1 share · 110 followers View post →