Aging Cell February 2022 PMID 35032339

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation.

Meilin Hu, Liangyu Xing, Li Zhang, Fan Liu, Sheng Wang, Ying Xie, Jingjing Wang, Hongmei Jiang, Jing Guo, Xin Li, Jingya Wang, Lei Sui, Changyi Li, Dayong Liu, Zhiqiang Liu

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Mentions

Peak: 7 in Jan 2022

across 2 sources since Jan 2022

Extended reach

78,799

potential audience

Total likes

408

Video views

12,113

Mentions per month

Jan 2022 – Feb 2023

Where it's discussed

X / Twitter13 posts
YouTube2 videos

AI synopsis

What people are saying

The group shows strong agreement on the significance of NAP1L2's role in MSC senescence, with posts discussing mechanisms like chromatin recruitment of SIRT1 and effects of NMN; the tone is optimistic and highlights potential benefits for aging-related diseases, indicating high interest and perceived impact.

AgreementStrong agreement

Most discussions acknowledge the significance of NAP1L2's role in stem cell aging and bone health, indicating strong consensus on its importance.

InterestHigh interest

Posts display high interest, with users referencing mechanistic details, such as NAP1L2's influence on chromatin structure and potential anti-aging interventions like NMN.

EngagementModerate engagement

While some comments briefly echo the main findings, others actively share related research, raising questions and highlighting the impact of the work, reflecting moderate deep engagement.

ImpactHigh impact

Multiple posts suggest the research offers breakthroughs with therapeutic implications for aging and osteoporosis, emphasizing its high impact on future treatments.

Abstract in brief

NAP1L2 is a key protein that increases in aging bone marrow mesenchymal stem cells (BMSCs), leading to cell aging (senescence) and reduced ability to generate new bone cells (osteogenesis).
The study found that NAP1L2 influences chromatin structure by recruiting SIRT1 to remove acetyl groups from histone H3K14, thereby suppressing genes essential for bone formation like Runx2, Sp7, and Bglap.
Interventions such as NMN (an anti-aging compound) can reduce NAP1L2's effects, potentially reversing cell aging and improving bone health, as supported by experiments in aging mice and human patients with osteoporosis.]

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All mentions

NMN Reverses Bone Stem Cell Aging by Targeting NAP1L2

This video reviews a study showing NMN inhibits NAP1L2, reducing senescence in bone marrow mesenchymal stem cells and promoting osteogenic differentiation, highlighting potential anti-aging strategies for bone health.

Modern Healthspan · Feb 20, 2022 11,940 views

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John Hemming · Feb 19, 2022 173 views

Sharpspeare

@SharpTusk · X

Feb 10, 2023 · 1 like · 8,016 followers View post →

The Phoenix Lab

@The_Phoenix_Lab · X

RT @agingdoc1: NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation https://t.co/6o4tKRFYZw

Apr 6, 2022 · 1 share · 209 followers View post →

Agingdoc

@agingdoc1 · X

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation https://t.co/6o4tKRFYZw

Apr 5, 2022 · 5 likes · 1 share · 41,813 followers View post →

Help Defeat Aging

@HelpDefeatAging · X

NMN Rejuvenates Bone Stem Cells https://t.co/bCyTvBWSS4

Feb 26, 2022 · 1 like · 1,966 followers View post →

Masterly Art

@MasterlyArt · X

NMN Rejuvenates Bone Stem Cells | Review By Modern Healthspan https://t.co/8GVD8aayqc via @YouTube

Feb 21, 2022 · 1 followers View post →

TimePie (focus on anti-aging science)

@TimePieChina · X

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation https://t.co/w6SEB5vcIJ 天津医科大研究人员发现，NMN与SIRT1蛋白结合以激活骨再生（成骨）基因，从而防止骨质疏松。

Feb 10, 2022 · 702 followers View post →

Osteoporosis-NL @osteoporosis-nl.bsky.social

@Osteoporosis_NL · X

Jan 21, 2022 · 1 like · 3,387 followers View post →

Michael Buratovich

@MichaelBuratovi · X

RT @MesenchymalCell:

Jan 18, 2022 · 2 shares · 1,166 followers View post →

Andy Blidy

@ablidy · X

RT @MesenchymalCell:

Jan 18, 2022 · 2 shares · 850 followers View post →

Mesenchymal Cell News

@MesenchymalCell · X

Jan 18, 2022 · 4 likes · 2 shares · 6,296 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation https://t.co/C9c6GO5ThF To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/mwsDjgagG3

Jan 17, 2022 · 883 followers View post →

Società Italiana di Gerontologia e Geriatria

@GeriSocITA · X

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation.: https://t.co/8HyVSN6AEL

Jan 16, 2022 · 725 followers View post →

Pedro Antonio Ávila-López

@pedroaavilaZ · X

RT @Nucleosome_Bot: NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation https://t.co/ePq33CjqJF

Jan 15, 2022 · 1 share · 655 followers View post →