A novel dermal delivery system using natural spicules for cosmetics and therapeutics.

Abstract in brief

• The research introduces a new dermal delivery system using natural siliceous spicules from freshwater sponges, which can efficiently carry and release active ingredients to improve skin treatments while reducing risks associated with oral or injectable methods.
• Active ingredients like pectolinarin are loaded into the spicules through liposome formations, and their ability to penetrate the skin, as tested on pig skin, shows promising absorption rates and controlled release patterns consistent with diffusion models.
• Overall, this innovative approach has the potential to enhance the effectiveness of cosmetic and therapeutic products by ensuring better skin absorption and stability of active compounds, paving the way for improved skin protection and treatment options.